Circulating osteoprotegerin and receptor activator of NF‐κB ligand system are associated with bone metabolism in middle‐aged males

Oh, Ki Won; Rhee, Eun-Jung; Lee, Won Young; Kim, Sun Woo; Baek, Ki Hyun; Kang, Moo Il; Yun, Eun Joo; Park, Cheol‐Young; Ihm, Sung Hee; Choi, Moon Gi; Yoo, Hyung Joon; Park, Sung Woo

doi:10.1111/j.1365-2265.2004.02179.x

Cited by 68 publications

(57 citation statements)

References 51 publications

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“…Published findings of serum OPG-bone mineral density (BMD) associations in humans have been inconsistent (3,(11)(12)(13)(14)(15)(16)(17)(18), and few studies have assessed the associations of RANKL (18)(19)(20) and the RANKL/ OPG ratio (20,21) with BMD. To test the a priori hypotheses that OPG-BMD associations are positive and RANKL-BMD associations are negative in humans, we conducted a cross-sectional and prospective study of the associations of serum levels of OPG, RANKL, and their ratio with BMD in older men and postmenopausal women, stratified by use of estrogen.…”

Section: Introductionmentioning

confidence: 99%

The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor κB legend with bone mineral density in older adults: the Rancho Bernardo Study

et al. 2007

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Objective: The role of osteoprotegerin (OPG) and its receptor activator of nuclear factor kB legend (RANKL) in the regulation of bone in humans remain unclear. We examined the sex-specific associations of serum OPG, RANKL, and their ratio with bone mineral density (BMD) in older adults. Design: Participants were 681 community-dwelling adults, ages 45-90 years, who had serum OPG and RANKL measured and bone density scans in 1988-1991, with follow-up scans 5 and/or 10 years later. Methods: Analyses were sex-specific; women using and not using estrogen were evaluated separately. Cross-sectional analyses used multivariable regression models; longitudinal analyses used repeated measures mixed effects models. Results: In cross-sectional analyses, age-and weight-adjusted serum OPG levels were significantly positively associated with BMD at the lumbar spine in men, and at the femoral neck, total hip, and lumbar spine in women using estrogen, but not in non-users of estrogen. RANKL concentrations were significantly and inversely associated with BMD in men only, and at the total hip. Neither OPG nor RANKL was significantly associated with bone loss. Results for the RANKL/OPG ratio were the same as those for RANKL alone. Conclusions: These results suggest a modulatory effect of both endogenous and exogenous sex hormones on the biologic interaction of OPG, RANKL, and bone.European Journal of Endocrinology 156 555-562

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Section: Introductionmentioning

confidence: 99%

The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor κB legend with bone mineral density in older adults: the Rancho Bernardo Study

et al. 2007

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“…Pa ti ents with low BMD at so me cer ta in si tes ha ve de mons tra ted hig her OPG 62 and sRANKL le vels; [63][64][65] or ne ga ti ve cor re la ti ons bet ween se rum OPG and RANKL le vels with BMD. 66 The se ne ga ti ve cor re la ti ons enab led the re se arc hers to pro po se a hypot he sis that sRANKL is in in ver se re la ti ons hip with BMD, ref lec ting the ex tent of oste oc las to ge ne sis and OPG might be in cre a sed as the com pen sa tory mec ha nism aga inst the ac ti vity of RANKL, to re du ce bo ne re sorp ti on.…”

Section: Opg-ranklmentioning

confidence: 99%

Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Karaarslan¹,

Büyükyazi²,

Taneli³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : To in ves ti ga te the ef fects of 12-we ek two-dif fe rent in ten sity re sis tan ce tra i ning prog rams on bo ne tur no ver mar kers, bo ne mi ne ral den sity (BMD), os te op ro to ge rin (OPG), and so lub le recep tor ac ti va tor of nuc le ar fac tor kap pa β li gand (sRANKL) in post me no pa u sal wo men. M Ma a t te e r ri i a al l a an nd d M Me et t --h ho od ds s: : Forty he althy wo men (aged 45-60 ye ars) par ti ci pa ted in the study. High-in ten sity gro up (HIG; n=14) wor ked 4 days a we ek and per for med two sets of 8-10 re pe ti ti ons at ~70-80% of 1 re pe at ma xi mum (RM). Low-in ten sity gro up (LIG; n= 13) wor ked in the sa me du ra ti on, with 13-17 re pe ti ti ons, at ~40-50% of 1RM. Con trol gro up (CG; n = 13) did not per form any exer ci ses. Body com po si ti on, 1RM va lu e for 10 exer ci ses, re pe ti ti ons of sit-ups for 30 se conds, bo ne for ma ti on and re sorp ti on mar kers, se rum os te o cal ci ne (OC), bone al ka li ne phosp ha ta se (BAP), βCross Labs, OPG, and sRANKL le vels we re me a su red be fo re and af ter the tra i ning prog ram. BMD was me a su red vi a du al energy X-ray ab sorp ti o metry. R Re e s su ul lt ts s: : Re sis tan ce tra i ning ca u sed in cre a ses in spi ne BMD in HIG and LIG (p< 0.05), and OC le vels in cre a sed in the HIG (p< 0.05). We ob ser ved a sig ni fi cant dif fe ren ce bet we en the per cent chan ge in HIG ver sus the per cent chan ge in CG in the spi ne BMD va lu es (p< 0.01). sRANKL le vels dec re a sed sig ni fi cantly in all three gro ups. Strength me asu res in cre a sed in both exer ci se gro ups (p< 0.001), fa vo ring the HIG. C Co on nc c l lu u s si i o on n: : High-in ten sity re sis tance tra i ning may be mo re ef fec ti ve for in cre a sing musc le strength and pro tec ting aga inst os te o po ro sis and frac tu res. Du e to in sig ni fi cant chan ges in OPG le vels and sig ni fi cant re duc ti ons in sRANKL in all gro ups, me a su res of cir cu la ting OPG and sRANKL le vels se em not to be so use ful to pre dict BMD or bo ne tur nover sta tus af ter re sis tan ce tra i ning prog rams. The re fo re, the se pa ra me ters re ma in to be de ter mi ned di rectly in the bo ne mic ro en vi ron ments to get her with BMD me a su res and bo ne tur no ver mar kers.K Ke ey y W Wo or rd ds s: : Os te o po ro sis, post me no pa u sal; RANK li gand; os te op ro te ge rin Ö ÖZ ZE ET T A Am ma aç ç: : İki fark lı yük len me şid de tin de ya pı lan 12 haf ta lık di renç an tren man prog ram la rı nın postme ne po zal dö nem de ki ka dın la rın, ke mik tur no ver mar ker le ri, ke mik mi ne ral yo ğun lu ğu (KMY), os te opro ge rin (OPG) ve so lub le nük le er fak tör kap pa Β re sep tör ak ti va tör li gan dı (sRANKL) üze ri ne olan et ki si ni be lir le mek. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Post-me no poz dö nem de ki 40 sağ lık lı ka dın (45-60 yaş) ça lış ma ya ka tıl -dı. Yük sek şid det gru bu (YŞG; n= 14) haf ta da 4 gün, 1 tek rar mak si mu mun (TM)...

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“…The chromosome 15 locus contains the gene for tumor necrosis factor receptor superfamily member 11B precursor (Tnfrsf11b or osteoprotegerin) at 54.3 Mb. Osteoprotegerin is a regulator of osteoclastogenesis (26). Interleukin 4-induced I (chromosome 7, 23.1 cM) and procollagen, type II, ␣1 (chromosome 15, 54.5 cM) also have been implicated as osteoporosis candidate genes (27).…”

Section: Discussionmentioning

confidence: 99%

Identification of quantitative trait loci affecting body composition in a mouse intercross

Vitarius

Sehayek

Breslow

2006

Proc. Natl. Acad. Sci. U.S.A.

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Gravimetric analysis and dual energy x-ray absorptiometry densitometry were used to determine lean, fat, and bone tissue traits in a F2 mouse population from a C57BL/6J and CASA/Rk intercross (B6CASAF2). These traits were used in a linkage analysis to identify quantitative trait loci that affect body composition. Linkage mapping showed that body weight (BW) loci on proximal chromosome 2 occurred in the same region as body length, lean tissue mass, and bone mineral content and on chromosome 13 in the same region as lean tissue mass, bone mineral density, and bone mineral content. Fat-related loci occurring on mid-chromosome 2 near 60 cM, proximal chromosome 6, and mid-chromosome 10 were distinct from BW, lean tissue, and bone tissue loci. In B6CASAF2 females, heterozygotes and CASA/Rk homozygotes at the chromosome 6 locus marker had higher body fat percentages, and this locus was responsible for 11% of the variance for body fat percentage. Female heterozygotes and C57BL/6J homozygotes at the chromosome 15 locus marker had higher bone mineral densities, and this locus could explain 8% of that trait's variance. A survey of the literature did not reveal any previous reports of fat-specific loci in the chromosomal 10 region near 42 cM reported in this study. The results of this study indicate that BW and BMI have limited usefulness as phenotypes in linkage or association studies when used as obesity phenotypes.body mass index ͉ bone mineral density ͉ dual energy x-ray absorptiometry ͉ lean tissue mass ͉ obesity

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Circulating osteoprotegerin and receptor activator of NF‐κB ligand system are associated with bone metabolism in middle‐aged males

Abstract: Our data show that the circulating OPG-RANKL system is associated with bone metabolism in the male populations. Also, our data suggest that OPG and RANKL may be mediators of the effects of oestradiol in male bone metabolism.

Cited by 68 publications

References 51 publications

The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor κB legend with bone mineral density in older adults: the Rancho Bernardo Study

The sex-specific association of serum osteoprotegerin and receptor activator of nuclear factor κB legend with bone mineral density in older adults: the Rancho Bernardo Study

Effects of Different Intensity Resistance Exercise Programs on Bone Turnover Markers, Osteoprotegerin and Receptor Activator of Nuclear Factor Kappa Β Ligand in Post-Menopausal Women

Identification of quantitative trait loci affecting body composition in a mouse intercross

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