Circulating omentin-1 levels in women with polycystic ovary syndrome: a meta-analysis

Tang, Yunliang; Yu, Jiao; Zeng, Zhenguo; Liu, Ying; Liu, Jianying; Xu, Jibin

doi:10.1080/09513590.2016.1254180

Cited by 22 publications

(16 citation statements)

References 28 publications

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“…Of the metabolic cytokines studied here, we only found that lipocalin-2 concentrations were increased in non-obese women with PCOS compared with female controls. The study of these circulating molecules on PCOS yielded largely discrepant results, not only with our present data, but also among earlier reports [56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71]. Such discrepancies might reflect the heterogeneity and complex nature of PCOS, but also differences among studies in the criteria used to diagnose the syndrome and in the characteristics of the population in terms of the association with obesity and other confounding factors which influence heavily metabolic variables.…”

Section: Discussioncontrasting

confidence: 59%

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

et al. 2019

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Scope: Cytokines have pleiotropic functions within the organism and their levels may be influenced by obesity, visceral adiposity and sex hormones. Diet composition may also affect their systemic concentrations during fasting and in the postprandial period. Hence, we studied the influence of sex steroids and obesity on the circulating levels of a panel of metabolic cytokines in the fasting state and after single macronutrient challenges. Methods: On alternate days we submitted 17 women with polycystic ovary syndrome (PCOS) (9 non-obese, 8 obese), 17 non-hyperandrogenic control women (9 non-obese, 8 obese) and 19 control men (10 non-obese, 9 obese) to isocaloric oral glucose, lipid and protein loads. Serum levels of omentin-1, vaspin, lipocalin-2, adipsin, PAI-1, chemerin, FGF-21 and FGF-23 were determined by Luminex multiplex technology. Results: During fasting, obese patients presented higher levels of PAI-1, chemerin and adipsin but decreased FGF-23 and omentin-1 compared with non-obese subjects. Vaspin showed sexual dimorphism with lower levels in men than women with PCOS and female controls. Following macronutrient ingestion, most metabolic cytokines presented a similar physiological response consisting of a decrease in circulating concentrations, which was inversely associated with the fasting levels of these molecules. Protein intake caused the major postprandial decrease whereas glucose did not significantly reduce PAI-1, FGF-23 and vaspin, and even increased FGF-21. Regardless of the macronutrient administered, vaspin levels showed a larger reduction in non-obese individuals while the decrease in PAI-1 was particularly noticeable in the obese subgroup. The postprandial reductions of omentin-1 and FGF-23 after glucose and protein loads were influenced by obesity. No major differences were found between patients with PCOS and male and female controls. Conclusions: Obesity, but not PCOS or sex, markedly influences metabolic cytokine levels at fasting and after macronutrient ingestion. The observed postprandial decrease in their circulating concentrations might represent a physiological compensatory mechanism against food-induced inflammation and oxidative stress. This mechanism is altered by obesity and is differently modulated by macronutrients, suggesting a larger contribution of glucose to stressful postprandial responses.

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Section: Discussioncontrasting

confidence: 59%

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

et al. 2019

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“…These differences elevate pro-inflammatory factors, accelerate inflammatory reactions, and bring about insulin resistance in PCOS patients [15,16]. In addition, obesity influences the degree of inflammation in patients with PCOS [17,18]. The mouse model of PCOS used in this study was in a state of chronic inflammation, with significantly higher concentrations of IL-6 and TNF-α than in the blank control.…”

Section: Discussionmentioning

confidence: 99%

Effect of berberine on hyperandrogenemia, ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome

Lu¹,

Lin²

2020

Trop. J. Pharm Res

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Purpose: To study the effect of berberine (BBR) on hyperandrogenemia (HA), ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome (PCOS).Methods: Forty-five female Kunming mice were randomly divided into control group (9 mice), and mice injected with dehydroepiandrosterone (n = 36) for establishment of PCOS model. The PCOS mice were randomly divided into model group, low-dose BBR (0.25 g/kg), medium-dose BBR (0.5 g/kg) and highdose (1.0 g/kg) groups, with 9 mice in each group. Changes in ovarian morphology were monitored, and sex hormone levels i.e. testosterone (T) and luteinizing hormone (LH)), and inflammatory factors were determined.Results: The model group levels of T and LH were significantly higher than those of the blank control group (p < 0.05), but T and LH levels were significantly lower in middle- and high-dose BBR groups than in the model mice. There were marked increases in IL-6 and TNF-α levels in model mice, when compared to blank control mice, but reduced in the mice treated at the 3 doses of BBR, relative to model mice (p < 0.05). In contrast, the number of follicles was higher at each stage of development in mice for each BBR dose than in the model mice, with increase in corpus luteum.Conclusion: Berberine lowers the weight of PCOS mice, mitigates hyperandrogenemia and inflammatory state, and enhances recovery of ovulation. However, there is need for further studies on its clinic applicability. Keywords: Berberine, Polycystic ovary syndrome, Hyperandrogenemia, Ovulation dysfunction, Inflammatory

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“…Serum and vitreous omentin-1 levels in patients with proliferative diabetic retinopathy were markedly decreased compared with those without diabetic retinopathy, with non-proliferative diabetic retinopathy, and with the healthy control subjects [177]. Meta-analysis conducted by Tang et al suggested that circulating omentin-1 levels are significantly lower in women with polycystic ovary syndrome compared with control subjects, which indicates that omentin-1 may play a role in the pathologic processes of polycystic ovary syndrome [178]. In analysing obstructive sleep apnoea syndrome, it was found that the omentin serum levels were low [179,180].…”

Section: Adipokinesmentioning

confidence: 99%

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

Suliga¹,

Wawszczak²,

Głuszek³

2018

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Metabolic syndrome (MetS) is defined as multiple risk factors including abdominal obesity, dyslipidaemia, abnormal glycaemia, and elevated blood pressure. The incidence of MetS and pathophysiological mechanisms underlying its development are still not fully understood. It is thought that the occurrence of MetS arises from the complex relationship between genetic and environmental factors. The aim of the study was to overview and summarise current knowledge regarding genetic determinants of MetS. Also analysed were the relationship between polymorphisms of the genes encoding selected adipokines (vaspin, chemerin, omentin) and the risk of MetS, as well as other metabolic disorders. The precise determination of MetS genotype is difficult because metabolic syndrome occurrence is a combination of multiple risk factors. A thorough understanding of pathomechanisms of MetS, involving selected adipokines, may in the future allow the use of these adipokines as potential biomarkers of metabolic disorder risk.

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Circulating omentin-1 levels in women with polycystic ovary syndrome: a meta-analysis

Cited by 22 publications

References 28 publications

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

Metabolic Cytokines at Fasting and During Macronutrient Challenges: Influence of Obesity, Female Androgen Excess and Sex

Effect of berberine on hyperandrogenemia, ovulation dysfunction and inflammation in a mouse model of polycystic ovary syndrome

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

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