Circulating of human bocavirus 1, 2, 3, and 4 in pediatric patients with acute gastroenteritis in Thailand

Khamrin, Pattara; Malasao, Rungnapa; Chaimongkol, Natthawan; Ukarapol, Nuthapong; Kongsricharoern, Tipachan; Okitsu, Shoko; Hayakawa, Satoshi; Ushijima, Hiroshi; Maneekarn, Niwat

doi:10.1016/j.meegid.2012.01.025

Cited by 36 publications

(39 citation statements)

References 24 publications

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“…Phylogenetic analysis of the study strains revealed presence of all four HBoV genotypes in Pune, Western India. Similar genetic diversity in HBoV strains from gastroenteritis cases has been reported previously from neighboring countries like Thailand, Pakistan, and Hong Kong [Lau et al, 2007;Khamrin et al, 2012;Alam et al, 2015].…”

Section: Discussionsupporting

confidence: 83%

Molecular epidemiology and clinical severity of Human Bocavirus (HBoV) 1–4 in children with acute gastroenteritis from Pune, Western India

Lasure

Gopalkrishna

2016

Journal of Medical Virology

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Although acute gastroenteritis is a major public health problem worldwide, ∼40% of the cases remain undiagnosed for any etiological agent. Human Bocavirus (HBoV) has been detected frequently in feces of diarrhoeic children suggesting its possible etiological involvement in the disease. HBoV has not been reported in association with acute gastroenteritis from India. Fecal samples (n = 418) collected from children (age ≤5 years) hospitalized with acute gastroenteritis, between January 2009 and December 2011, from three local hospitals were examined for presence of HBoV using PCR targeting the partial VP1/VP2 capsid region (∼575 bp) followed by phylogenetic analysis. HBoV was detected in 24/418 (5.7%) cases. Co-infection was observed in 5/24 (21%) cases. HBoV infections occurred in children ≤12 months of age. Peak HBoV activity was observed in monsoon and post monsoon season. All four HBoV genotypes were detected in the study region. Major clinical symptoms of HBoV mono infections included diarrhoea (100%), fever (90%), dehydration (74%), and vomiting (58%). Dehydration was observed in all of the HBoV2-4 cases and in 50% of the HBoV1 cases. Clinical severity varied with genotype (HBoV2 > HBoV1 > HBoV3 > HBoV4). HBoV2 cases recorded severe and very severe infections. The study illustrates prevalence and vast genetic diversity of HBoVs in acute gastroenteritis. It highlights the clinical features of HBoV1-4 infections and sheds light on clinical impact of HBoV genotypes in gastroenteritis. J. Med. Virol. 89:17-23, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 83%

Molecular epidemiology and clinical severity of Human Bocavirus (HBoV) 1–4 in children with acute gastroenteritis from Pune, Western India

Lasure

Gopalkrishna

2016

Journal of Medical Virology

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“…The reports on HBoV in Africa, other developing countries, and worldwide in individuals suffering from respiratory tract infection 78% (55/70) were higher compared to those suffering from gastroenteritis 21% (15/70) (Tables 1, 2, and 3). This could be due to the fact that most studies focused on HBoV in respiratory tract infection since its discovery in 2005 [28,33,36,71]. However recent studies are increasingly detecting HBoV in individuals suffering from diarrheal diseases due to the presence of the virus in stool samples of individuals suffering from gastroenteritis [37,[72][73][74].…”

Section: Resultsmentioning

confidence: 99%

“…Primary infection with HBoV occurs early in life in children between 6-24 months of age [32][33][34]; however, older children and adults can also be infected [28,35]. Currently there is no specific approved treatment or vaccine for HBoV infection [25,36,37]. Since its discovery, the virus was mainly associated with respiratory tract infections, but recent studies have revealed the involvement of the virus in gastroenteritis.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea

Rikhotso

Kabue

Ledwaba

et al. 2018

Journal of Tropical Medicine

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Background Human Bocavirus (HBoV) is an emerging virus discovered in 2005 from individuals suffering gastroenteritis and respiratory tract infections. Numerous studies related to the epidemiology and pathogenesis of HBoV have been conducted worldwide. This review reports on HBoV studies in individuals with acute gastroenteritis, with and without respiratory tract infections in Africa between 2005 and 2016. Material and Method The search engines of PubMed, Google Scholar, and Embase database for published articles of HBoV were used to obtain data between 2005 and 2016. The search words included were as follows: studies performed in Africa or/other developing countries or/worldwide; studies for the detection of HBoV in patients with/without diarrhea and respiratory tract infection; studies using standardized laboratory techniques for detection. Results The search yielded a total of 756 publications with 70 studies meeting the inclusion criteria. Studies included children and individuals of all age groups. HBoV prevalence in Africa was 13% in individuals suffering gastroenteritis with/without respiratory tract infection. Conclusion Reports suggest that HBoV infections are increasingly being recognized worldwide. Therefore, surveillance of individuals suffering from infections in Africa is required to monitor the prevalence of HBoV and help understand the role of HBoV in individuals suffering from gastroenteritis with/without respiratory tract infection.

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“…8,9 HBoV1 is the most commonly reported genotype and occurring primarily in pediatric patients with respiratory tract infection, but also gastrointestinal symptoms are often observed. 10,11 In contrast, HBoV2 are preferentially detected in stool samples and appear to be more strongly associated with enteric disease, HBoV3 and HBoV4 are occasionally detected in faeces and too rare for any associations. 2 Since the discovery of HBoVs, numerous epidemiological surveillance efforts examining HBoV prevalence in children have been performed across multiple regions, comprising Thailand, United States, France, Jordan and Brazil.…”

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confidence: 99%

Genetic characterization of human bocavirus among children with severe acute respiratory infection in China

Wang

Liu

et al. 2016

Journal of Infection

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Circulating of human bocavirus 1, 2, 3, and 4 in pediatric patients with acute gastroenteritis in Thailand

Cited by 36 publications

References 24 publications

Molecular epidemiology and clinical severity of Human Bocavirus (HBoV) 1–4 in children with acute gastroenteritis from Pune, Western India

Molecular epidemiology and clinical severity of Human Bocavirus (HBoV) 1–4 in children with acute gastroenteritis from Pune, Western India

Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea

Genetic characterization of human bocavirus among children with severe acute respiratory infection in China

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