Circulating NT-proBNP but not soluble corin levels were associated with preeclampsia in pregnancy-associated hypertension

Abstract

Background: Corin is a serine protease known to convert B-type natriuretic peptide (BNP) prohormone into BNP and its amino-terminal fragment (NT-proBNP). In mice lacking corin, high blood pressure and proteinuria were found at late gestational stages, with associated delayed trophoblast invasion and impaired spiral artery remodeling in the uterus. We hypothesize that both NT-proBNP and soluble corin elevation predict the presence of preeclampsia in pregnant patients with hypertension. Methods:We prospectively enrolled 149 pregnant women with a history of chronic hypertension or gestational hypertension presenting at a tertiary-care hospital. We compared plasma NT-proBNP and soluble corin concentrations based on their preeclamptic status.Results: In our study cohort, 62 patients with preeclampsia had lower gestational age than 87 patients without preeclampsia (33.3±3 versus 36.6±3 weeks; P<0.001), otherwise the baseline characteristics were similar. We observed higher NT-proBNP concentrations in patients with preeclampsia compared to those without preeclampsia (304.3 [96.34, 570.4] vs. 60.8 [35.

Multiplex Analysis of Circulating Maternal Cardiovascular Biomarkers Comparing Preeclampsia Subtypes

“…Other studies have identified that particularly women with EPE have altered cardiac structure and function, along with increased circulating levels of the well-established cardiovascular biomarker NTproBNP. 56,74,75 The dysregulated CVD biomarkers identified in the preeclamptic pregnancies likely reflect heterogeneous physiological and pathological processes linked to the pregnancy stress of PE, and particularly to EPE, which is also linked to the highest degree of placental cellular stress (e.g endoplasmic reticulum stress). 76 Whether these biomarkers also can be used for targeting women at highest risk for long-term CVD, and therefore for intervention trials and personalized medicine, is an exciting possibility to explore in longitudinal studies.…”

Prediction of adverse maternal and perinatal outcomes in preeclampsia based on B-type natriuretic peptide: a retrospective study

“…During normal pregnancy, BNP is maintained at a relatively low level (a median level of <20 pg/mL) (12,19). However, the PE women were shown to have significantly higher BNP levels in the third trimester (10)(11)(12)(13)(14). The BNP level of PE with severe features was higher than that of PE without severe features (10,12), while the BNP of early-onset PE was higher than lateonset PE (11,14).…”

“…Studies on BNP in PE have mainly focused on its diagnosis or prediction of the disease and its relationship with the associated cardiovascular complications. In PE, the BNP levels reflect the severity of the PE (10)(11)(12)(13)(14), and elevated BNP levels are associated with ventricular systolic or diastolic dysfunction (24)(25)(26). Kumari et al (13) found that BNP levels in women with chronic hypertension and gestational hypertension who later superimposed or progressed to PE were significantly higher than those who did not develop PE, and the ROC curve analysis showed that BNP had a good value in predicting the development of PE in the study population (AUC =0.7406, 95% CI: 0.6543-0.827, P<0.0001).…”

“…The neuroendocrine hormone, B-type natriuretic peptide (BNP), is mainly synthesized and secreted by the cardiac ventricles, and was first confirmed to play an important role in the development of hypertension (9). In recent years, studies have shown that the increased BNP level is closely related to PE, and it has been believed that BNP plays an important role in the pathophysiology of PE (10)(11)(12)(13)(14). Some researchers have proposed that BNP can be used as an indicator of the severity of PE or a predictor of preeclampsia, and some clinicians use this to monitor the condition changes of pregnant women with PE (15).…”

Immunological and physiopathological approach of COVID-19 in pregnancy

“…There is an association of NT-proBNP levels with RAS component levels in pregnant women [219]. Some studies have focused on the increased circulating levels of natriuretic peptides in pregnant women suffering from PE, mainly in its early and severe form [219][220][221]. PE involves a failure of the maternal cardiovascular system to adapt to the demands of pregnancy, therefore a cardiac origin of NT-proNBP was first attributed.…”