Circulating Non-Coding RNAs in Head and Neck Cancer: Roles in Diagnosis, Prognosis, and Therapy Monitoring

Diez-Fraile, Araceli; Ceulaer, J. De; Derpoorter, Charlotte; Spaas, Christophe; Backer, Tom De; Lamoral, P.; Abeloos, J.; Lammens, Tim

doi:10.3390/cells10010048

Cited by 16 publications

(13 citation statements)

References 83 publications

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“…Although a significant progress on the pathogenesis of HNSCC has been made in the past decades, the exact molecular mechanisms are still not well understood. Increasing evidences implicates that dysregulation of miRNAs has a critical role in the development and progression of HNSCC (4)(5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

A Super-Enhancer Driven by FOSL1 Controls miR-21-5p Expression in Head and Neck Squamous Cell Carcinoma

et al. 2021

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MiR-21-5p is one of the most common oncogenic miRNAs that is upregulated in many solid cancers by inhibiting its target genes at the posttranscriptional level. However, the upstream regulatory mechanisms of miR-21-5p are still not well documented in cancers. Here, we identify a super-enhancer associated with the MIR21 gene (MIR21-SE) by analyzing the MIR21 genomic regulatory landscape in head and neck squamous cell carcinoma (HNSCC). We show that the MIR21-SE regulates miR-21-5p expression in different HNSCC cell lines and disruption of MIR21-SE inhibits miR-21-5p expression. We also identified that a key transcription factor, FOSL1 directly controls miR-21-5p expression by interacting with the MIR21-SE in HNSCC. Moreover, functional studies indicate that restoration of miR-21-5p partially abrogates FOSL1 depletion-mediated inhibition of cell proliferation and invasion. Clinical studies confirmed that miR-21-5p expression is positively correlated with FOSL1 expression. These findings suggest that FOSL1-SE drives miR-21-5p expression to promote malignant progression of HNSCC

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Section: Introductionmentioning

confidence: 99%

A Super-Enhancer Driven by FOSL1 Controls miR-21-5p Expression in Head and Neck Squamous Cell Carcinoma

et al. 2021

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“…EBV ctDNA is another promising biomarker with low cost and high sensitivity for predicting disease recurrence [ 46 ]. For non-viral-driven subtypes of HNSCC, specific mutations, methylation markers, or RNA expression have been explored as biomarkers [ 24 , 26 , 50 , 51 , 52 , 53 , 56 , 57 , 64 , 67 , 68 , 69 , 79 , 80 , 81 , 82 ].…”

Section: Discussionmentioning

confidence: 99%

“…For HPV-positive tumors, HPV16 E6/E7 ctRNA expression in circulating tumor cells has proven useful as a biomarker for clinically relevant HPV infection in HPV-positive OPSCC [ 79 ]. In addition, circulating microRNA and long non-coding RNA expression has been recently reviewed [ 80 ]. Finally, circular RNAs have also gained attention.…”

Section: The Value Of Ctrna In Cancer Monitoringmentioning

confidence: 99%

Tracking the Molecular Fingerprint of Head and Neck Cancer for Recurrence Detection in Liquid Biopsies

Diez-Fraile

Ceulaer

Derpoorter

et al. 2022

IJMS

Self Cite

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The 5-year relative survival for patients with head and neck cancer, the seventh most common form of cancer worldwide, was reported as 67% in developed countries in the second decade of the new millennium. Although surgery, radiotherapy, chemotherapy, or combined treatment often elicits an initial satisfactory response, relapses are frequently observed within two years. Current surveillance methods, including clinical exams and imaging evaluations, have not unambiguously demonstrated a survival benefit, most probably due to a lack of sensitivity in detecting very early recurrence. Recently, liquid biopsy monitoring of the molecular fingerprint of head and neck squamous cell carcinoma has been proposed and investigated as a strategy for longitudinal patient care. These innovative methods offer rapid, safe, and highly informative genetic analysis that can identify small tumors not yet visible by advanced imaging techniques, thus potentially shortening the time to treatment and improving survival outcomes. In this review, we provide insights into the available evidence that the molecular tumor fingerprint can be used in the surveillance of head and neck squamous cell carcinoma. Challenges to overcome, prior to clinical implementation, are also discussed.

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“… 29 Therefore, due to non‐specific symptoms in the early stages and lack of effective diagnostic biomarkers for HNSCC, the majority of HNSCC patients are diagnosed at an advanced stage (III and IV), at which point survival rates are low relative to those for early stages (I and II). 30 Due to the stability, tissue specificity, and the spatiotemporal specificity of circRNA, it could be a novel biomarker in early diagnosis of cancer patients. 31 , 32 In this study, we also calculated ROC curves to assess the value of hsa_circ_0016148 in HNSCC diagnosis.…”

Section: Discussionmentioning

confidence: 99%

The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma

Shen

Wang

Dong

2021

Clinical Laboratory Analysis

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Head and neck cancers are the seventh most common forms of cancer worldwide, encompassing a wide range of tumors arising from numerous anatomic subsites including the nasal cavity, paranasal sinuses, nasopharynx, oral cavity, lips, oropharynx, hypopharynx, and larynx. 1 Head and neck squamous cell carcinoma (HNSCC) is the most frequent histological type, accounting for more than 90% of head and neck cancers. 2,3 The incidence of HNSCC is approximately 1,000,000 patients diagnosed worldwide, and about

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Circulating Non-Coding RNAs in Head and Neck Cancer: Roles in Diagnosis, Prognosis, and Therapy Monitoring

Cited by 16 publications

References 83 publications

A Super-Enhancer Driven by FOSL1 Controls miR-21-5p Expression in Head and Neck Squamous Cell Carcinoma

A Super-Enhancer Driven by FOSL1 Controls miR-21-5p Expression in Head and Neck Squamous Cell Carcinoma

Tracking the Molecular Fingerprint of Head and Neck Cancer for Recurrence Detection in Liquid Biopsies

The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma

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