Circulating neuropeptide Y in humans: relation to changes in catecholamine levels and changes in hemodynamics

Hauser, Gabriel J.; Danchak, M; Colvin, M. P.; Hopkins, Richard A.; Wocial, B; Myers, Adam K.; Zukowska‐Grojec, Zofia

doi:10.1016/s0143-4179(96)90083-9

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…Finaly NPY, the sympathetic co-transmitter which causes vasoconstriction, decreases coronary blood flow and decreases cardiac output (Hauser et al 1996) was seen to diminish significantly with the two levels of exercise, hence, denoting positive circulatory adaptations with exercise. The fact that the chronic circulating levels of the immunoreactive NPY decreased to a similar extent with both exercise intensities reinforces the effectiveness of lower exercise intensity in the older age group.…”

Section: Molecular Background Of the Observed In Vivo Muscle Charactementioning

confidence: 92%

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Onambélé-Pearson

Breen

Stewart

2010

AGE

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Long-term adherence to training programmes is difficult to attain. Yet, the benefits of exercise to general health and well-being are undeniable. Any measure to demonstrate the minimum required exercise for maximal benefit to a person is a promising avenue towards increasing the uptake and adherence to physical activity for the general public. The purpose of this study was to compare the effects of two different intensities of resistance training in healthy older adults. We hypothesised that compared to high-intensity resistance exercise, relatively low training intensity could also improve in vivo markers of healthy physiologic and endocrine functions in previously sedentary older individuals. Thirty (out of a possible 34 recruited) older adults were randomly assigned to low (LowR, i.e. ∼40% one repetition maximum (1RM)) versus high-resistance training (HighR, i.e. ∼80% 1RM) for 12 weeks. Neither intervention significantly impacted upon body composition markers including: body mass index (BMI), waist/hip ratio and bioelectric impedance. Muscle strength data showed an advantage for the HighR protocol with 51±4% and 22.4±10.2% (P<0.05) improvements in 1RM strength and bilateral knee extension torque, respectively, compared with 17±1% and 10.3±4.7% (P<0.05) increments in 1RM strength and bilateral torque in the LowR group. Unilateral torque did not change significantly in either group. Quadriceps muscle thickness data also showed a significantly greater benefit of the HighR protocol (5.8±2.6% increase) compared with the LowR protocol (no change). Functional ability tests, including Get-up-and-go (GUG), Standing from lying and the 6-min walk, showed changes of −11.6 ± 4.8%, −15.6% and 8.5±1.7% (P<0.05), respectively, in HighR compared with only one significant improvement in the LowR, namely a −10.8±3% (P<0.05) improvement in the GUG test. Overnight fasting serum levels of IGFBP-3 increased, NPY decreased and TNF-α decreased significantly in the LowR group. Serum levels of glucose increased and NPY decreased significantly in HighR. Circulating levels of I, IL-6 and IGF-1 did not change with either intervention. In vivo physiologic changes show functional advantages for older persons carrying out AGE (2010) 32:139-153

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Section: Molecular Background Of the Observed In Vivo Muscle Charactementioning

confidence: 92%

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Onambélé-Pearson

Breen

Stewart

2010

AGE

View full text Add to dashboard Cite

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“…Central to this compensation is the development of cardiac hypertrophy and augmentation of the m a s of contractile tissue with or without chamber dilatation (Gerdes et al 1996, Bassand 1995. Stimulation of the adrenergic (Hauser et al 1996, Xiong et al 1996, Anfossi and Trwati 1996, Kinugawa et al-1996, and reninangiotensin-aldosterone systems, as weii as other neurohumoral adjustments can act to maintain arterial pressure and thus perfusion to vital organs (Teerlink 1996, Kato et al 1996. Activation of the renin-angiotensinaldosterone system also increases Ouid retention, which acts as a compensatory mechanism to maintain arterial blood pressure and cardiac output (Luchner et al 1996).…”

Section: Introductionmentioning

confidence: 99%

“…other adaptive mechanisms are Viggered to optimize perhision of the body tissues. These include: a) development of cardiac hypertrophy with or without chamber dilatation to augment the mass of contractile tissue (Gerdes et al 1996, Bassand 1995; b) an increase in the catecholamuie release to increase myocardial contractility (Hauser et al 1996, Xiong et al 1996, Anfossi and Trovati 1996, Kinugawa et al 2996 (Norgaard et al 1990). …”

Section: Introductionmentioning

confidence: 99%

Myocardial oxidative stress changes during compensated right heart failure in rats

Pichardo

Palace

Farahmand

et al. 1999

Stress Adaptation, Prophylaxis and Treatment

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“…The experimental evidence suggests that NPY participates in the blood pressure regulation during severe stress (22–24). However, data on the impact of sepsis on systemic NPY levels seem to be less consistent, documenting both increase and no change in NPY plasma concentrations in relation to sepsis (25,26).…”

Section: Discussionmentioning

confidence: 99%

Plasma and Tissue Levels of Neuropeptide Y in Experimental Septic Shock: Relation to Hemodynamics, Inflammation, Oxidative Stress, and Hemofiltration

et al. 2011

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Neuropeptide Y (NPY), a potent vasoconstrictor released from the sympathetic nerves, has been suggested to counterbalance sepsis-induced vasodilation. Thus, the changes in plasma and tissue NPY concentrations in relation to hemodynamic variables and inflammatory markers in a porcine model of moderate septic shock were investigated. Susceptibility of NPY to be removed by continuous hemofiltration in two settings has been also studied. Thirty-four domestic pigs were divided into five groups: (i) control group; (ii) control group with conventional hemofiltration; (iii) septic group; (iv) septic group with conventional hemofiltration; and (v) septic group with high-volume hemofiltration. Sepsis induced by fecal peritonitis continued for 22 h. Hemofiltration was applied for the last 10 h. Hemodynamic and inflammatory parameters (heart rate, mean arterial pressure, cardiac output, systemic vascular resistance, plasma concentrations of tumor necrosis factor-α, interleukin-6, and NPY) were measured before and at 12 and 22 h of peritonitis. NPY tissue levels were determined in the left ventricle and mesenteric and coronary arteries. Sepsis induced long-lasting increases in the systemic NPY levels without affecting its tissue concentrations. Continuous hemofiltration at any dose did not reduce sepsis-induced elevations in NPY plasma concentrations, nor did it affect the peptide tissue levels. The increases in NPY systemic levels were significantly correlated with changes in the systemic vascular resistance. The results support the hypothesis of NPY implication in the regulation of the vascular resistance under septic conditions and indicate that NPY clearance rate during hemofiltration does not exceed the capacity of perivascular nerves to release it.

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Circulating neuropeptide Y in humans: relation to changes in catecholamine levels and changes in hemodynamics

Cited by 9 publications

References 20 publications

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Influence of exercise intensity in older persons with unchanged habitual nutritional intake: skeletal muscle and endocrine adaptations

Myocardial oxidative stress changes during compensated right heart failure in rats

Plasma and Tissue Levels of Neuropeptide Y in Experimental Septic Shock: Relation to Hemodynamics, Inflammation, Oxidative Stress, and Hemofiltration

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