Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock
Robert S. Rogers,
Rohit Sharma,
Hardik B. Shah
et al.
Abstract:Introduction
Sepsis is a highly morbid condition characterized by multi-organ dysfunction resulting from dysregulated inflammation in response to acute infection. Mitochondrial dysfunction may contribute to sepsis pathogenesis, but quantifying mitochondrial dysfunction remains challenging.
Objective
To assess the extent to which circulating markers of mitochondrial dysfunction are increased in septic shock, and their relationship to severity and mo… Show more
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