Circulating miRNAs in acute new‐onset atrial fibrillation and their target mRNA network

Silva, Ananília Medeiros Gomes da; Araújo, Jéssica Nayara Góes de; Oliveira, Katiene Macêdo de; Novaes, Ana Eloisa; Lopes, Mariana Borges Sodré; Sousa, Júlio César Vieira de; Filho, Antônio Amorim de Araújo; Luchessi, André Ducati; Rezende, Adriana Augusto de; Hirata, Mário Hiroyuki; Silbiger, Vivian Nogueira

doi:10.1111/jce.13612

Cited by 27 publications

(19 citation statements)

References 27 publications

(54 reference statements)

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“…The associations of hsa-miR-133b and AF has been reported by several studies but different expression patterns were observed. da Silva et al found that hsa-miR-133b was up-regulated in acute new-onset AF patients with a 1.4-fold increased expression compared with well-controlled AF patients and control patients (da Silva et al, 2018). Li et al (2012) reported that miR-133 was down-regulated in chronic AF canines.…”

Section: Resultsmentioning

confidence: 99%

The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation

et al. 2019

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Atrial fibrillation (AF) is the most common irregular heart rhythm which influence approximately 1–2% of the general population. As a potential factor for ischemic stroke, AF could also cause heart failure. The mechanisms behind AF pathogenesis is complex and remains elusive. As a new category of non-coding RNAs (ncRNAs), circular RNAs (circRNAs) have been known as the key of developmental processes, regulation of cell function, pathogenesis of heart diseases and pathological responses which could provide novel sight into the pathogenesis of AF. circRNAs function as modulators of microRNAs in cardiac disease. To investigate the regulatory mechanism of circRNA in AF, especially the complex interactions among circRNA, microRNA and mRNA, we collected the heart tissues from three AF patients and three healthy controls and profiled their circRNA expressions with circRNA Microarray. The differentially expressed circRNAs were identified and the biological functions of their interaction microRNAs and mRNAs were analyzed. Our results provided novel insights of the circRNA roles in AF and proposed highly possible interaction mechanisms among circRNAs, microRNAs, and mRNAs.

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Section: Resultsmentioning

confidence: 99%

The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation

et al. 2019

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“…Ultimately, only 40 studies fulfilled the eligibility criteria for meta-analysis after excluding duplicates, conference abstracts, reviews, letters, irrelevant studies, and studies that lacked important information. 3,5–10,26,28,29,31–34,36,39,40,44–66 Specific reasons for the exclusion of studies are listed in Supplementary Table 2. The list of the 40 studies characteristics is given in Tables 1 and 2.…”

Section: Resultsmentioning

confidence: 99%

“…The tissue-related specificity exists in the miRNA expression, and miR-375 and miR-113b expression differed between blood samples 3,7,32 and tissue. 36,57 A total of 54 miRNAs were consistently differentially expressed in atrial tissue, among which increased miR-328 and decreased miR-1 were identified.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression signatures of atrial fibrillation: The critical systematic review and bioinformatics analysis

Shen

Zhang

et al. 2019

Exp Biol Med (Maywood)

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Association between microRNA (miRNA) expression signatures and atrial fibrillation has been evaluated with inconsistent findings in different studies. This study aims to identify miRNAs that actually play vital role in pathophysiological process of atrial fibrillation and explore miRNA-targeted genes and the involved pathways. Relevant studies were retrieved from the electronic databases of Embase, Medline, and Cochrane Library to determine the miRNA expression profiles between atrial fibrillation subjects and non-atrial fibrillation controls. Robustness of results was assessed using sensitivity analysis. Subgroup analyses were performed based on species, miRNA detection method, sample source, and ethnicity. Quality assessment of studies was independently conducted according to QUADAS-2. Bioinformatics analysis was applied to explore the potential genes and pathways associated with atrial fibrillation, which were targeted by differentially expressed miRNAs. Form of pooled results was shown as log10 odds ratios (logORs) with 95% confidence intervals (CI), and random-effects model was used. In total, 40 articles involving 283 differentially expressed miRNAs were reported. And 51 significantly dysregulated miRNAs were identified in consistent direction, with 22 upregulated and 29 downregulated. Among above-mentioned miRNAs, miR-223-3p (logOR 6.473; P < 0.001) was the most upregulated, while miR-1-5p (logOR 7.290; P < 0.001) was the most downregulated. Subgroup analysis confirmed 53 significantly dysregulated miRNAs (21 upregulated and 32 downregulated) in cardiac tissue, with miRNA-1-5p and miRNA-223-3p being the most upregulated and downregulated miRNAs, respectively. Additionally, miR-328 and miR-1-5p were highly blood-specific, and miR-133 was animal-specific. In the detection method sub-groups, miRNA-29b and miRNA-223-3p were differentially expressed consistently. Four miRNAs, including miRNA-223-3p, miRNA-21, miRNA-328, and miRNA-1-5p, were consistently dysregulated in both Asian and non-Asian. Results of sensitivity analysis showed that 47 out of 51 (92.16%) miRNAs were dysregulated consistently. Totally, 51 consistently dysregulated miRNAs associated with atrial fibrillation were confirmed in this study. Five important miRNAs, including miR-29b, miR-328, miR-1-5p, miR-21, and miR-223-3p may act as potential biomarkers for atrial fibrillation. Impact statement Atrial fibrillation (AF) is considered as the most common arrhythmia, and it subsequently causes serious complications including thrombosis and heart failure that increase the social burden. The definite mechanisms underlying AF pathogenesis remain complicated and unclear. Many studies attempted to discover the transcriptomic changes using microarray technologies, and the present studies for this hot topic have assessed individual miRNAs profiles for AF. However, results of different articles are controversial and not each reported miRNA is actually associated with the pathogenesis of AF. The present systematic review and meta-analysis identified that 51 consistently dysregulated miRNAs were associated with AF. Of these miRNAs, five miRNAs (miRNA-1-5p, miRNA-328, miRNA-29b, miRNA-21, and miRNA-223-3p) may act as novel biomarkers for AF. The findings could offer a better description of the biological characteristics of miRNAs, meanwhile might serve as new target for the intervention and monitoring AF in future studies.

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“…In both cases, this will reduce the level of protein encoded by the mRNA [14]. The regulation of miRNAs is highly complex, one miRNA can target multiple mRNAs simultaneously and one mRNA can be regulated by a variety of different miRNAs [15,16]. MiRNAs regulate gene expression in order to maintain their proper function and homeostasis.…”

Section: Types and Nomenclaturementioning

confidence: 99%

Molecular Mechanisms, Diagnostic Aspects and Therapeutic Opportunities of Micro Ribonucleic Acids in Atrial Fibrillation

Böhm

Vachalcová²,

Snopek

et al. 2020

IJMS

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Micro ribonucleic acids (miRNAs) are short non-coding RNA molecules responsible for regulation of gene expression. They are involved in many pathophysiological processes of a wide spectrum of diseases. Recent studies showed their involvement in atrial fibrillation. They seem to become potential screening biomarkers for atrial fibrillation and even treatment targets for this arrhythmia. The aim of this review article was to summarize the latest knowledge about miRNA and their molecular relation to the pathophysiology, diagnosis and treatment of atrial fibrillation.

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Circulating miRNAs in acute new‐onset atrial fibrillation and their target mRNA network

Cited by 27 publications

References 27 publications

The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation

The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation

MicroRNA expression signatures of atrial fibrillation: The critical systematic review and bioinformatics analysis

Molecular Mechanisms, Diagnostic Aspects and Therapeutic Opportunities of Micro Ribonucleic Acids in Atrial Fibrillation

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