Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer

Radanova, Maria; Mihaylova, Galya; Mihaylova, Zornitsa; Ivanova, Desislava; Tasinov, Oskan; Nazifova-Tasinova, Neshe; Pavlov, P. S.; Mirchev, Milko; Conev, Nikolay; Donev, Ivan

doi:10.3390/curroncol28020116

Cited by 6 publications

(3 citation statements)

References 39 publications

(64 reference statements)

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“…Rs2682818 is located in the hairpin-loop structure of the miR-618 precursor, which may affect the process of miR-618 interaction with its target [ 98 ]. Our recent study showed that the deregulated expression of the circulating miR-618 in Caucasian patients with colon cancer was not altered because of rs2682818 variants [ 99 ]. We also found that rs2682818 AC genotype was associated with a decreased risk of colon cancer.…”

Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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There is growing interest in single nucleotide polymorphisms (SNPs) in the genes of microRNAs (miRNAs), which could be associated with susceptibility to colorectal cancer (CRC) and therefore for prognosis of the disease and/or treatment response. Moreover, these miRNAs-SNPs could serve as new, low-invasive biomarkers for early detection of CRC. In the present article, we performed a thorough review of different SNPs, which were investigated for a correlation with the CRC risk, prognosis, and treatment response. We also analyzed the results from different meta-analyses and the possible reasons for reported contradictory findings, especially when different research groups investigated the same SNP in a gene for a particular miRNA. This illustrates the need for more case-control studies involving participants with different ethnic backgrounds. According to our review, three miRNAs-SNPs—miR-146a rs2910164, miR-27a rs895819 and miR-608 rs4919510—appear as promising prognostic, diagnostic and predictive biomarkers for CRC, respectively.

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Section: Single Nucleotide Polymorphisms (Snps) In Genes For Mirnas Associated With Colorectal Cancer (Crc) Riskmentioning

confidence: 99%

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

et al. 2022

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“…The potential usefulness of other circulating miRNAs as biomarkers of mCRC has been extensively studied [1,12,24] MiR-203, miR-618, and miR-200c in serum were identified as promising biomarkers to predict metastasis [15,25,31,32]. These studies also showed the aberrant expression of miR-203 along the individual stages of carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Can Plasma miR-122-5p and miR-142-5p Predict Relapse in Metastatic Colorectal Cancer Patients?

et al. 2023

jdismarkers

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Approximately 20% of colorectal cancer patients already suffer from metastases at the time of diagnosis. Perhaps more serious, about 50% of the patients with localized tumours will eventually develop metastases during the course of their disease. A current hypothesis suggests that acquired or intrinsic chemoresistance is one of the major causes of metastasis. Recently, we found that circulating miR-122-5p and miR-142-5p could be used to predict both patient outcome and response to therapy. In the present study, we validate our previous results in patients with metastatic colorectal cancer (n=18), taking blood samples at three different times; i.e. metastasis resection surgery (T0), ~1 month after surgery (T1), and~8 months after surgery (T2). The expression levels of miR-122-5p and miR-142-5p were analysed in plasma and plasma extracellular vesicles (EVs) through RT-qPCR. The obtained results were compared against serum CEA and CA 19-9 levels, and computed tomography scans. The rectal cancer patients in the good prognostic group showed significantly increased miR-142-5p expression profile between T1 and T2; whereas the poor prognostic group showed a lower expression during T2 when compared with T1. The decreased expression of miR-142-5p in the latter group could also be seen in the EVs of the patients. This is consistent with our previous study, where the downregulation of miR-142-5p could be associated with poor response to therapy. In addition, the individual analyses showed that the downregulation of both miRNAs predicted tumour relapse at an earlier time point than the markers CEA and CA 19-9. In conclusion, the obtained data from this study demonstrates that miR-142-5p and miR-122-5p could be used as predictive bio-markers of tumour relapse in cases of metastatic rectal cancer, although further validation is still needed.

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“…Low expression of circulating miR-618 in patients suffering from metastatic CRC is connected with shorter overall survival. The results of this study indicate that the level of miR-618 in the blood can be tested as a prognostic biomarker in patients with metastatic CRC [ 152 ].…”

Section: Role Of Selected Micrornas In Gastrointestinal Cancersmentioning

confidence: 99%

Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

Kalita

Sikora-Skrabaka

Nowakowska-Zajdel

2023

CIMB

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Gastrointestinal (GI) cancers are some of the most common cancers in the world and their number is increasing. Their etiology and pathogenesis are still unclear. ADAM proteins are a family of transmembrane and secreted metalloproteinases that play a role in cancerogenesis, metastasis and neoangiogenesis. MicroRNAs are small single-stranded non-coding RNAs that take part in the post-transcriptional regulation of gene expression. Some ADAM proteins can be targets for microRNAs. In this review, we analyze the impact of microRNA/ADAM protein axes in GI cancers.

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Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer

Cited by 6 publications

References 39 publications

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

Can Plasma miR-122-5p and miR-142-5p Predict Relapse in Metastatic Colorectal Cancer Patients?

Role of Some microRNA/ADAM Proteins Axes in Gastrointestinal Cancers as a Novel Biomarkers and Potential Therapeutic Targets—A Review

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