Circulating miR-221-3p as a novel marker for early prediction of acute myocardial infarction

Çoşkunpınar, Ender; Çakmak, Hüseyin Altuğ; Kalkan, Ali Kemal; Tiryakioglu, Necip Ozan; Ertürk, Mehmet; Öngen, Zeki

doi:10.1016/j.gene.2016.06.059

Cited by 70 publications

(52 citation statements)

References 26 publications

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“…Such as Wu et al [21] reported that the tumour suppressive role of miR-221-3p in epithelial ovarian cancer and directly target ARF4, suggesting the miR-221-3p might be a novel potential candidate for clinical prognosis and therapeutics of epithelial ovarian cancer. However, studies about miR-221-3p are rare in PCa [22][23][24]. In the current study, found miR-221-3p is overexpressed in PCa tissues compared with adjacent non-tumour tissues and circulating miR-221-3p level is correlated with distant metastases of PCa patients.…”

Section: Introductionmentioning

confidence: 45%

MicroRNA-221-3p is up-regulated and serves as a potential biomarker in pancreatic cancer

Feng

Wang

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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It has been demonstrated that circulating MicroRNAs (miRNAs) could be potential biomarkers for cancer diagnosis and prognosis. For pancreatic cancer (PCa), little is known about miR-221-3p biological function or its prognostic value. In the current study, we profiled miR-221-3p expression in PCa cell lines. Compared with normal pancreases ductal epithelial cells, miR-221-3p is up-regulated in all PCa cell lines analysed. In SW1990 cells, overexpression of miR-221-3p increased cell proliferation and inhibited apoptosis, while inhibition of miR-221-3p decreased cell growth rate and promoted apoptosis. Compared with adjacent non-tumour tissues, miR-221-3p was up-regulated in all 21 PCa tissues. Expression level of miR-221-3p was investigated in plasma and statistical analyses showed that circulating miR-221-3p expression level was correlated with distant metastasis and TNM stages. The receiver-operating characteristic (ROC) curves and the area under the ROC curve (AUC) suggested that the diagnostic efficacy for distant metastasis of miR-221-3p is better than CA19-9 (AUC: 0.689 vs. 0.587). To summary, we found miR-221-3p could promote cell proliferation and inhibit apoptosis in PCa cells and circulating miR-221-3p could serve as a biomarker for PCa.

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Section: Introductionmentioning

confidence: 45%

MicroRNA-221-3p is up-regulated and serves as a potential biomarker in pancreatic cancer

Feng

Wang

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…Clinical studies, including miRNAs that had both diagnostic and prognostic significance in the setting of acute myocardial infarction, are shown in Table 1 (49)(50)(51)(52)(53)(54)(55)(56). Coskunpinar et al (57) reported an increase of miR-221-3p in subjects with acute myocardial infarction, which were correlated with ejection fraction (inversely), troponin, and risk scores. In addition, it was reported to be a good candidate as a biomarker in this setting (57).…”

Section: Mirna and Acute Myocardial Infarctionmentioning

confidence: 99%

MicroRNA and Cardiovascular Diseases

2020

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Cardiovascular diseases are one of the most common causes of death in both developing and developed countries worldwide. Even though there have been improvements in primary prevention, the prevalence of cardiovascular diseases continues to increase in recent years. Hence, it is crucial to both investigate the molecular pathophysiology of cardiovascular diseases in-depth and find novel biomarkers regarding the early and proper prevention and diagnosis of these diseases. MicroRNAs, or miRNAs, are endogenous, conserved, single-stranded non-coding RNAs of 21-25 nucleotides in length. miRNAs have important roles in various cellular events such as embryogenesis, proliferation, vasculogenesis, apoptosis, cell growth, differentiation, and tumorigenesis. They also have potential roles in the cardiovascular system, including angiogenesis, cardiac cell contractility, control of lipid metabolism, plaque formation, the arrangement of cardiac rhythm, and cardiac cell growth. Circulating miRNAs are promising novel biomarkers for purposes of the diagnosis and prognosis of cardiovascular diseases. Cell or tissue specificity, stability in serum or plasma, resistance to degradative factors such as freeze-thaw cycles or enzymes in the blood, and fast-release kinetics, provide the potential for miRNAs to be surrogate markers for the early and accurate diagnosis of disease and for predicting middle-or longterm prognosis. Moreover, it may be a logical approach to combine miRNAs with traditional biomarkers to improve risk stratification and long-term prognosis. In addition to their efficacy in both diagnosis and prognosis, miRNA-based therapeutics may be beneficial for treating cardiovascular diseases using novel platforms and computational tools and in combination with traditional methods of analysis. microRNAs are promising, novel therapeutic agents, which can affect multiple genes using different signaling pathways. miRNAs therapeutic modulation techniques have been used in the settings of atherosclerosis, acute myocardial infarction, restenosis, vascular remodeling, arrhythmias, hypertrophy and fibrosis, angiogenesis and cardiogenesis, aortic aneurysm, pulmonary hypertension, and ischemic injury. This review presents detailed information about miRNAs regarding structure and biogenesis, stages of synthesis and functions, expression profiles in serum/plasma of living organisms, diagnostic and prognostic potential as novel biomarkers, and therapeutic applications in various diseases.

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“…With regards to new biomarkers in the early diagnosis of ACS, in a proof of concept study Coskunpinar et al 7 assessed the potential diagnostic role of circulating micro-RNAs in patients with ACS. They found that miR-221-3p was significantly positively correlated with Tn levels, GRACE and SYNTAX Score and inversely correlated with post-MI left ventricular systolic function.…”

Section: Troponinsmentioning

confidence: 99%