Circulating miR-21 levels in hypertensive patients with asymptomatic organ damage

Abstract

As a modifiable risk factor for cardiovascular disease, presence of hypertension (HT) necessitates the awareness of asymptomatic organ damage (AOD). The aim of this study was to measure plasma micro RNA-21 (miR-21) and the parameters that reflect AOD such as carotid intima-media thickness (CIMT), microalbuminuria (MAU) in hypertensive patients compared with healthy controls. In addition, the aim of this study was to evaluate plasma miR-21 levels in HT patients with AOD.This study was designed as a cross-sectional observational study. The study includes 2 groups: 32 patients with HT and 32 healthy controls. First, we compared these 2 groups. Then, to underline the relationship between plasma miR-21 and HT, hypertensive patients were divided into 2 groups: with AOD and without AOD.Sixteen patients with HT had AOD. MiR-21 levels significantly correlated with clinical systolic and diastolic blood pressure, MAU, C-reactive protein, and CIMT. CIMT, miR-21, and MAU levels were significantly higher in patients with AOD.Our study showed increased miR-21 levels in HT patients with AOD.

MicroRNA Profiles in Normotensive and Hypertensive South African Individuals

“…Furthermore, the significant relationship between miR-30a-5p expression and screen-detected and known HPT was demonstrated. Several studies have reported on a number of dysregulated miRNAs in HPT using different tissues, but results remain inconsistent (21)(22)(23)(24)(25). A study similar to ours reported 27 dysregulated miRNAs in a sample of 13 individuals with HPT (21), although the miRNAs were not similar to ours.…”

MicroRNA 21 and microRNA 155 levels in resistant hypertension, and their relationships with aldosterone

“…In our previous study of 52 controls and 51 HT patients under follow-up in the Cappadocia cohort, we investigated the place of miRNA 4516, miRNA 181a, miRNA 24, and miRNA 145 in the pathogenesis of essential HT, and showed that a decrease in miRNA 145 and an increase in miRNA 4516 may be involved [ 9 ]. In addition to examining the role of miRNAs in the pathogenesis of essential HT, studies have also investigated their relationship with end-organ damage [ 11 , 12 , 25 ]. Numerous studies have particularly evaluated the role of miRNA 21 in the pathogenesis of essential HT and its relationship with end-organ damage [ 26 ].…”

“…Yıldırım et al. similarly investigated 32 HT and 32 healthy controls and showed that miRNA 21 is associated with asymptomatic organ damage in the hypertensive population [ 12 ]. In their experimental study, Chen et al.…”

Two novel microRNAs and their association with absolute blood pressure parameters in an urban South African community

“…Whilst the relationship between expression of these two novel miRNAs and BP variables or HPT status cannot be directly compared to similar studies (as our findings are novel), differential expression of miRNAs in HPT has been previously reported [5,13] and expression of miRNAs has also been related to BP parameters. For instance, one study showed a significant correlation between SBP and the expression of miR-21, miR-126 and miR-34a has been reported, whilst miR-146a expression was correlated with SBP and DBP [23].…”

“…Using small RNA sequencing techniques, epigenome studies continue to describe novel miRNAs in various body tissues and disease conditions [ 3 , 4 ]. These miRNAs are 18–22 nucleotides long [ 5 ] and are involved in the regulation of gene expression at the post transcription level, either through targeted messenger RNA (mRNA) degradation or inhibition of translation [ 3 , 6 ]. As such, they have a crucial role in maintaining the homeostatic balance of the human body’s processes and dysregulations in their expression may be related to disease processes [ 7 , 8 ].…”