Circulating microRNAs Showed Specific Responses according to Metabolic Syndrome Components and Sex of Adults from a Population-Based Study

Brandão-Lima, Paula Nascimento; Carvalho, Gabrielli Barbosa de; Payolla, Tanyara Baliani; Sarti, Flávia Mori; Fisberg, Regina Mara; Malcomson, Fiona C.; Mathers, John C.; Rogero, Marcelo Macedo

doi:10.3390/metabo13010002

Cited by 7 publications

(4 citation statements)

References 47 publications

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“…These miRNAs have previously demonstrated dysregulated pro les in individuals with metabolic disorders such as prediabetes, T2DM, MetS, and obesity. Notably, hsa-miR-16-5p, found at reduced levels in Brazilian women with MetS [43], has also shown a positive correlation with insulin sensitivity in non-diabetic, weight-stable individuals. Furthermore, hsa-miR-17-5p, hsa-miR-21-5p and hsa-miR-320a are shown to have decreased abundance in metabolically dysregulated individuals compared to healthy counterparts [44].…”

Section: Discussionmentioning

confidence: 96%

Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis

Tautuiaki,

Gojer,

Jayaprakash

et al. 2024

Preprint

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Purpose Piper excelsum (kawakawa), a vascular plant endemic to Aotearoa, New Zealand, is of cultural and medicinal importance to Māori. Presence of biologically active compounds in kawakawa may underpin its putative beneficial health properties, particularly its anti-inflammatory effects. However, no human studies on its anti-inflammatory effects exist. Method Blood samples from a crossover two-arm randomised controlled trial to assess the impact of ingesting kawakawa tea (4g leaves/250 mL hot-water) on postprandial plasma abundances of microRNAs (miRNA) involved in metabolic-related pathways and their respective gene and protein targets in healthy human volunteers (n = 26; Age; 33.6 ± 1.9 (yr) and BMI; 22.5 ± 0.4 (kg/m2)) compared to water control, were used for the analysis. Results Nine miRNAs showed significantly different abundances following the two interventions. The abundance of hsa-miR-17-5p, -21-5p, -320a-5p, let-7g-5p, -16-5p, -122-5p, and − 144-3p was upregulated in response to kawakawa intake compared to water and the expression of hsa-miR-221-3p and − 223-3p was downregulated in kawakawa intake compared to water over a120 min postprandial period. In-silico analysis indicated miRNA enrichment in metabolic-related pathways, such as apoptosis, cytokine signaling, MAPK signaling, and MTOR pathways. Furthermore, the postprandial expression of IL-8 (p = 0.03), IL-6 (p = 0.01) and PPAR-γ was significanly reduced following kawakawa consumption compared to water control. While as IL-6 cytokine was significantly increased at 120 min in the kawakawa intervention only compared to baseline. Conclusion These findings highlight the interconnected nature of metabolic regulation pathways and highlight the need for further intervention studies to explore the chronic anti-inflammatory effects of kawakawa. Clinical Trial Registration: The clinical trial is registered with Australian New Zealand Clinical Trials Registry ( ACTRN12621000311853).

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Section: Discussionmentioning

confidence: 96%

Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis

Tautuiaki,

Gojer,

Jayaprakash

et al. 2024

Preprint

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“… 5 Likewise, a prospective study reported raised levels of microRNA-30a in people with prediabetes compared to normal subjects, and this rise occurred many years before the occurrence of diabetes. 25 Also, Koh et al illustrated that the expression of microRNA-30a protected adipose tissue from the harmful effects of inflammatory mediators, leading to a reduction in insulin resistance in obese mice. 26 Conversely, the suppression of microRNA-30a was found to have a protective effect on pancreatic beta cells and enhanced glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

Circulating MicroRNA-30a, Beclin1 and Their Association with Different Variables in Females with Metabolically Healthy /Unhealthy Obesity

Naguib,

Magdy,

Yousef

et al. 2023

DMSO

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Background Obesity is associated with metabolic and cardiovascular co-morbidities. It is important to determine the factors associated with metabolic derangement in obesity. Autophagy plays a major role in the pathogenesis of metabolic syndrome. MicroRNA-30a targets beclin1, the main regulator of autophagy. Purpose We assess circulating microRNA-30a and serum beclin1 in women with metabolically unhealthy obesity (MUO), women with metabolically healthy obesity (MHO) and non-obese healthy control and determine their relationship with different clinical and metabolic variables in women with obesity. Patients and Methods This cross-sectional study included 34 women with MHO, 34 with MUO, and 20 healthy non-obese women. Blood pressure, body mass index (BMI), and waist circumference were recorded. Glycemic and lipid indices, urinary albumin-to-creatinine ratio, ALT, AST, microRNA-30a expression in serum were measured using real-time polymerase chain reaction and beclin1 by enzyme-linked immunosorbent assay were measured. Results The expression of microRNA-30a was significantly higher, and beclin1 level was significantly lower in women with MUO compared to those in women with MHO (P<0.001; for both). People with MUO were significantly older (P<0.001) and had higher TSH (P=0.006), HbA1c (P<0.001), triglyceride (P<0.001), and ALT (P<0.001) compared to women with MHO. However, there was no significant difference between the two groups in any anthropometric measurements, HDL-C or LDL-C. In univariate analyses, age, ALT, TSH, microRNA-30a, and beclin1 were significantly correlated with the MUO phenotype (P<0.001; for all). Significance was confirmed in the multivariate analysis for microRNA-30a (95% CI 1.317–28.252; P=0.021). Conclusion MicroRNA-30a, beclin1, age, and ALT and TSH levels were significantly associated with the MUO phenotype, among which microRNA-30a was the best indicator of metabolic syndrome in women with obesity.

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“…Generally, metabolic disorders increase the risk of cardiovascular disease (CVD) and cancer 75 . In addition, it has been highlighted that miRNA expression in plasma is a potential biomarker for obesity 76,77 . However, since AT, especially the white AT (WAT), has a major role in obesity, it is important to better understand its role in extracellular crosstalk with other tissues.…”

Section: Role Of Ev‐containing Mirnas In Obesity and Metabolic Syndromementioning

confidence: 99%

Role of micro‐RNAs associated with adipose‐derived extracellular vesicles in metabolic disorders

Payet,

Gabinaud,

Landrier

et al. 2024

Obesity Reviews

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SummaryMicro‐RNAs have emerged as important actors in the onset of metabolic disorders including obesity or type 2 diabetes. Particularly, several micro‐RNAs are known to be key modulators of lipid metabolism, glucose homeostasis, or feeding behavior. Interestingly, the role of extracellular vesicles containing micro‐RNAs, especially adipose‐derived extracellular vesicles, are well‐documented endocrine signals and disease biomarkers. However, the role of adipose‐derived extracellular vesicles on the different tissues is different and highly related to the micro‐RNA content. This review provides recent data about the potential involvement of adipose‐derived extracellular vesicle‐containing micro‐RNAs in metabolic diseases.

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Circulating microRNAs Showed Specific Responses according to Metabolic Syndrome Components and Sex of Adults from a Population-Based Study

Cited by 7 publications

References 47 publications

Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis

Kawakawa tea Intake and its anti-diabetic and anti-inflammatory effects: An integrative microRNA and mRNA analysis

Circulating MicroRNA-30a, Beclin1 and Their Association with Different Variables in Females with Metabolically Healthy /Unhealthy Obesity

Role of micro‐RNAs associated with adipose‐derived extracellular vesicles in metabolic disorders

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