Circulating microRNAs in Hidradenitis Suppurativa

Abstract

Hidradenitis suppurativa (HS) is a pathology characterized by chronic inflammation and skin lesions. The molecular basis of the inflammatory network remains unclear; however, since microRNAs (miRNAs) are involved in the modulation of inflammation, the composition of a micro-transcriptome RNA library using the blood of HS patients was analysed here. The total miRNA expression profiles of miRNAs from HS patients was assayed by real-time qPCR. Here, compared to healthy controls, miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR-338-5p expression was found significantly different in HS. Knowing the significance of the miRNA mechanism in inflammatory and immune progression, we suggest that miRNA profiles found in HS patients can be significant in understanding the pathogenesis modality and establishing efficient biomarkers for HS early diagnosis. In particular, miR-338-5p was closely related to HS invasiveness and production of cytokines and was atypically overexpressed. miR-338-5p may represent a good promise as a non-invasive clinical biomarker for HS.

LncRNA microarray profiling identifies novel circulating lncRNAs in hidradenitis suppurativa

“…The main driver of pathogenesis in HS is an overactivation of immune-cell infiltration, which leads to an enhancement of the inflammatory response due to the release of pro-inflammatory cytokines and chemokines. The inflammation may become chronic and, in severe cases, adversely affects diverse tissues and organs ( 33 ). Currently, the etiopathogenesis of HS remains poorly understood due to the complexity and the multifactorial nature of the disease.…”

Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa

“…Despite recent strides, notably in the work of De Felice et al ( De et al, 2022 ), the exploration of miRNAs within the clinical framework of HS remains at its preliminary stages. While the potential of miRNAs as early detection biomarkers for HS is promising, there are challenges to overcome.…”

“…A recent study by De Felice et al ( De et al, 2022 ) employed conventional molecular techniques to reveal distinctive miRNA expression profiles, notably miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR-338-5p, in HS patients compared to healthy controls. Of particular significance is the overexpression of miR-338-5p in HS lesional tissue, intricately linked to invasiveness and the secretion of pro-inflammatory cytokines; this finding led the authors to postulate its pivotal role in HS pathogenesis.…”

Discovering KYNU as a feature gene in hidradenitis suppurativa

“…65 Another study revealed significant differences in the expression of miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR-338-5p in HS. 66 Currently, there is a lack of studies investigating the role of lncRNA in HS. In our study, we performed a comprehensive analysis and successfully constructed a ceRNA network of KYNU specifically for HS.…”