Circulating microRNAs: Association with disease and potential use as biomarkers

Reid, Glen; Kirschner, Michaela B.; Zandwijk, Nico van

doi:10.1016/j.critrevonc.2010.11.004

Cited by 422 publications

(394 citation statements)

References 82 publications

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“…Circulating miRNAs have received considerable attention as potential biomarkers of various diseases (Reid et al, 2011) based on many studies reporting differences in plasma or serum miRNA levels between healthy subjects and patients. However, it remains unclear to what extent the circulating miRNA profiles in healthy subjects vary in daily life due to changes in diet, supplements, alcohol intake, cigarette smoking, exposure to environmental chemicals, sleeping or circadian rhythm, stress, and exercise or other factors.…”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects

Takahashi

Yokota

Tatsumi

et al. 2013

Toxicology and Applied Pharmacology

116

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Circulating microRNAs (miRNAs) are receiving attention as potential biomarkers of various diseases, including cancers, chronic obstructive pulmonary disease, and cardiovascular disease. However, it is unknown whether the levels of circulating miRNAs in a healthy subject might vary with external factors in daily life. In this study, we investigated whether cigarette smoking, a habit that has spread throughout the world and is a risk factor for various diseases, affects plasma miRNA profiles. We determined the profiles of 11 smokers and 7 non-smokers by TaqMan MicroRNA array analysis. A larger number of miRNAs were detected in smokers than in non-smokers, and the plasma levels of two thirds of the detected miRNAs (43 miRNAs) were significantly higher in smokers than in non-smokers. A principal component analysis of the plasma miRNA profiles clearly separated smokers and non-smokers. Twenty-four of the miRNAs were previously reported to be potential biomarkers of disease, suggesting the possibility that smoking status might interfere with the diagnosis of disease. Interestingly, we found that quitting smoking altered the plasma miRNA profiles to resemble those of non-smokers. These results suggested that the differences in the plasma miRNA profiles between smokers and non-smokers could be attributed to cigarette smoking. In addition, we found that an acute exposure of ex-smokers to cigarette smoke (smoking one cigarette) did not cause a dramatic change in the plasma miRNA profile. In conclusion, we found that repeated cigarette smoking substantially alters the plasma miRNA profile, interfering with the diagnosis of disease or signaling potential smoking-related diseases.

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Section: Discussionmentioning

confidence: 99%

Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects

Takahashi

Yokota

Tatsumi

et al. 2013

Toxicology and Applied Pharmacology

116

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“…Comparing to the intracellular RNA, miRNA in exosomes is more stable, and has advantages in storage for the resistance to degradation in frozen environment (Reid et al, 2011). Nowadays, the utilize of exosomes for targeted therapy has become the major topic of debate.…”

Section: Discussionmentioning

confidence: 99%

Exosome-derived microRNA-29c Induces Apoptosis of BIU-87 Cells by Down Regulating BCL-2 and MCL-1

Xu¹,

Wu²,

Fan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (8), 3471-3476 IntroductionThe incidence of bladder carcinoma is in the first in Chinese urological tumor, which includes the 70% non invasive cancer and 30% invasive cancer. The patients accompanied with systemic metastasis have poor prognosis and a lifetime risk of recurrence.Tumor-derived exosomes had been regarded as a good carrier of anti-tumor therapy for its advantages of tumor specific antigen recognition, easy to obtain. For example, exosomes from tumor cells treated by heat shock or genetic modification were associated with ODN-CpG adjuvants to deal with the tumor bearing mice, showing that it enhanced the antitumor activity of the secretion of exosomes (Chaput et al., 2004). Researches on exosomesderived miRNA indicated that it could be used as a new

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“…miRNAs are resistant to nucleases due to their small size and the fact that in body fluids, they are likely protected in extracellular evesicles (EVs) or bound to protein or high‐density lipoprotein (HDL) binding partners (Brase, Wuttig, Kuner & Sultmann, 2010; Cortez et al., 2012; Reid, Kirschner & van Zandwijk, 2011; Wagner et al., 2013). This reservoir of miRNAs may transit to other cells and tissues where in some cases they influence gene regulation and may play a role in physiology and pathology (Hergenreider et al., 2012; Wei et al., 2017; Zhang et al., 2010, 2015).…”

Section: Introductionmentioning

confidence: 99%

Extracellular RNA profiles with human age

Dluzen

Hooten

et al. 2018

Aging Cell

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SummaryCirculating extracellular RNAs (exRNAs) are potential biomarkers of disease. We thus hypothesized that age‐related changes in exRNAs can identify age‐related processes. We profiled both large and small RNAs in human serum to investigate changes associated with normal aging. exRNA was sequenced in 13 young (30–32 years) and 10 old (80–85 years) African American women to identify all RNA transcripts present in serum. We identified age‐related differences in several RNA biotypes, including mitochondrial transfer RNAs, mitochondrial ribosomal RNA, and unprocessed pseudogenes. Age‐related differences in unique RNA transcripts were further validated in an expanded cohort. Pathway analysis revealed that EIF2 signaling, oxidative phosphorylation, and mitochondrial dysfunction were among the top pathways shared between young and old. Protein interaction networks revealed distinct clusters of functionally‐related protein‐coding genes in both age groups. These data provide timely and relevant insight into the exRNA repertoire in serum and its change with aging.

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Circulating microRNAs: Association with disease and potential use as biomarkers

Cited by 422 publications

References 82 publications

Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects

Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects

Exosome-derived microRNA-29c Induces Apoptosis of BIU-87 Cells by Down Regulating BCL-2 and MCL-1

Extracellular RNA profiles with human age

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