Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus

Jaeger, Andrea; Zollinger, Lukas; Saely, Christoph H.; Muendlein, Axel; Evangelakos, Ioannis; Nasias, Dimitris; Charizopoulou, Nikoleta; Schofield, Jonathan; Othman, Alaa; Soran, Handrean; Kardassis, Dimitris; Eckardstein, Arnold von

doi:10.1038/s41598-018-32274-9

Cited by 45 publications

(33 citation statements)

References 67 publications

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“…Finally, Jaeger et al revealed elevated serum levels of miR-192, miR-194 and miR-215 linked with the presence of both T1DM and T2DM in patients, whereas miR-192 and miR-194 were correlated with the incidence of new-onset T2DM in 6 years of follow-up. The latter miRNAs were also elevated in diabetic Akt2 knockout mice [213]. Another interesting miRNA associated with IR is miR-802.…”

Section: Mirnas In Mets-a Link With Obesity and Insulin Resistance/hymentioning

confidence: 91%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.

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Section: Mirnas In Mets-a Link With Obesity and Insulin Resistance/hymentioning

confidence: 91%

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Włodarski

Strycharz

Wróblewski

et al. 2020

IJMS

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“…Another early dysregulated miRNAs in DN progression is the miR-192 (Kato et al, 2009;Krupa et al, 2010;Jia et al, 2016;Andrea et al, 2018). MiR-192 is the most abundant miRNA in the kidney, in which its high expression protects the kidney function (Krupa et al, 2010).…”

Section: Micrornas In Renal Hypertrophy and Ecm Accumulationmentioning

confidence: 99%

Interactions Among Non-Coding RNAs in Diabetic Nephropathy

et al. 2020

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Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic targets. NcRNAs refers to the RNA species that do not encode for any protein, and the most known ncRNAs are the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Dysregulation of these ncRNAs was reported before in DN patients and animal models of DN. Importantly, there are some interactions between these ncRNAs to regulate the crucial steps in DN progression. Here, we aimed to discuss the reported ncRNAs in DN and their interactions with critical genes in DN progression. Elucidating these ncRNAs regulatory network will allow for a better understanding of the molecular mechanisms in DN and how they can act as new biomarkers for DN and also as the potential targets for treatment.

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“…In the last five years, together with immune cell subsets, several studies have proposed blood circulating microRNAs (miRNAs) as novel promising biomarkers for metabolic and autoimmune diabetes and related complications [19][20][21][22][23][24][25][26][27][28][29][30][31]. Inside cells, these small (~22 nucleotides in length) and highly conserved non-coding RNAs regulate mRNA decay and protein translation [32].…”

Section: Introductionmentioning

confidence: 99%

Blood Co-Circulating Extracellular microRNAs and Immune Cell Subsets Associate with Type 1 Diabetes Severity

Garavelli

Bruzzaniti

Tagliabue

et al. 2020

IJMS

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Immune cell subsets and microRNAs have been independently proposed as type 1 diabetes (T1D) diagnostic and/or prognostic biomarkers. Here, we aimed to analyze the relationships between peripheral blood circulating immune cell subsets, plasmatic microRNAs, and T1D. Blood samples were obtained from both children with T1D at diagnosis and age-sex matched healthy controls. Then, immunophenotype assessed by flow cytometry was coupled with the quantification of 60 plasmatic microRNAs by quantitative RT-PCR. The associations between immune cell frequency, plasmatic microRNAs, and the parameters of pancreatic loss, glycemic control, and diabetic ketoacidosis were assessed by logistic regression models and correlation analyses. We found that the increase in specific plasmatic microRNAs was associated with T1D disease onset (let-7c-5p, let-7d-5p, let-7f-5p, let-7i-5p, miR-146a-5p, miR-423-3p, and miR-423-5p), serum C-peptide concentration (miR-142-5p and miR-29c-3p), glycated hemoglobin (miR-26a-5p and miR-223-3p) and the presence of ketoacidosis (miR-29c-3p) more strongly than the evaluated immune cell subset frequency. Some of these plasmatic microRNAs were shown to positively correlate with numbers of blood circulating B lymphocytes (miR-142-5p) and CD4+CD45RO+ (miR-146a-5p and miR-223-3p) and CD4+CD25+ cells (miR-423-3p and miR-223-3p) in children with T1D but not in healthy controls, suggesting a disease-specific microRNA association with immune dysregulation in T1D. In conclusion, our results suggest that, while blood co-circulating extracellular microRNAs and immune cell subsets may be biologically linked, microRNAs may better provide powerful information about T1D onset and severity.

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Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus

Cited by 45 publications

References 67 publications

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress

Interactions Among Non-Coding RNAs in Diabetic Nephropathy

Blood Co-Circulating Extracellular microRNAs and Immune Cell Subsets Associate with Type 1 Diabetes Severity

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