Circulating microRNA profiles in Wilms tumour (WT): A systematic review and meta-analysis of diagnostic test accuracy

Benlhachemi, Sara; Abouqal, Redouane; Coleman, Nicholas; Murray, Matthew Jonathan; Khattab, Mohammed; El fahime, Elmostafa

doi:10.1016/j.ncrna.2023.05.007

Cited by 3 publications

(1 citation statement)

References 62 publications

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“… 15 , 16 Studies investigating circulating miRNAs in patients with WT have identified candidate biomarker lists for further interrogation, 15 , 17 recently reviewed elsewhere. 18 Furthermore, circulating miRNA signatures appears independent of pre-operative chemotherapy treatment. 19 Given the heterogeneity of WT, a formal robust consensus diagnostic panel of miRNAs for WT has not yet been established, and therefore we did not pursue circulating miRNA testing in our single patient here.…”

Section: Discussionmentioning

confidence: 99%

Wilms Tumor With Raised Serum Alpha-Fetoprotein: Highlighting the Need for Novel Circulating Biomarkers

Green,

Ahmed,

Fleming

et al. 2023

Pediatr Dev Pathol

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Wilms tumor (WT) is the commonest cause of renal cancer in children. In Europe, a diagnosis is made for most cases on typical clinical and radiological findings, prior to pre-operative chemotherapy. Here, we describe a case of a young boy presenting with a large abdominal tumor, associated with raised serum alpha-fetoprotein (AFP) levels at diagnosis. Given the atypical features present, a biopsy was taken, and histology was consistent with WT, showing triphasic WT, with epithelial, stromal, and blastemal elements present, and positive WT1 and CD56 immunohistochemical staining. During pre-operative chemotherapy, serial serum AFP measurements showed further increases, despite a radiological response, before a subsequent fall to normal following nephrectomy. The resection specimen was comprised of ~55% and ~45% stromal and epithelial elements, respectively, with no anaplasia, but immunohistochemistry using AFP staining revealed positive mucinous intestinal epithelium, consistent with the serum AFP observations. The lack of correlation between tumor response and serum AFP levels in this case highlights a more general clinical unmet need to identify WT-specific circulating tumor markers.

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Section: Discussionmentioning

confidence: 99%

Wilms Tumor With Raised Serum Alpha-Fetoprotein: Highlighting the Need for Novel Circulating Biomarkers

Green,

Ahmed,

Fleming

et al. 2023

Pediatr Dev Pathol

Self Cite

View full text Add to dashboard Cite

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miRNAs Role in Wilms tumor pathogenesis: Signaling pathways interplay

Alfaifi

2024

Pathology - Research and Practice

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Insights into Personalized Care Strategies for Wilms Tumor: A Narrative Literature Review

Karam,

Gebreil,

Alksas

et al. 2024

Biomedicines

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Wilms tumor (WT), or nephroblastoma, is the predominant renal malignancy in the pediatric population. This narrative review explores the evolution of personalized care strategies for WT, synthesizing critical developments in molecular diagnostics and treatment approaches to enhance patient-specific outcomes. We surveyed recent literature from the last five years, focusing on high-impact research across major databases such as PubMed, Scopus, and Web of Science. Diagnostic advancements, including liquid biopsies and diffusion-weighted MRI, have improved early detection precision. The prognostic significance of genetic markers, particularly WT1 mutations and miRNA profiles, is discussed. Novel predictive tools integrating genetic and clinical data to anticipate disease trajectory and therapy response are explored. Progressive treatment strategies, particularly immunotherapy and targeted agents such as HIF-2α inhibitors and GD2-targeted immunotherapy, are highlighted for their role in personalized treatment protocols, especially for refractory or recurrent WT. This review underscores the necessity for personalized management supported by genetic insights, with improved survival rates for localized disease exceeding 90%. However, knowledge gaps persist in therapies for high-risk patients and strategies to reduce long-term treatment-related morbidity. In conclusion, this narrative review highlights the need for ongoing research, particularly on the long-term outcomes of emerging therapies and integrating multi-omic data to inform clinical decision-making, paving the way for more individualized treatment pathways.

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Circulating microRNA profiles in Wilms tumour (WT): A systematic review and meta-analysis of diagnostic test accuracy

Cited by 3 publications

References 62 publications

Wilms Tumor With Raised Serum Alpha-Fetoprotein: Highlighting the Need for Novel Circulating Biomarkers

Wilms Tumor With Raised Serum Alpha-Fetoprotein: Highlighting the Need for Novel Circulating Biomarkers

miRNAs Role in Wilms tumor pathogenesis: Signaling pathways interplay

Insights into Personalized Care Strategies for Wilms Tumor: A Narrative Literature Review

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