Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification

Chao, Chia‐Ter; Liu, You-Pi; Su, Sheng‐Fang; Yeh, Hsiang‐Yuan; Chen, Hsuan‐Yu; Lee, Pei-Jung; Chen, Wan-Jiun; Lee, Yee-Ming; Huang, Jenq‐Wen; Chiang, Chih‐Kang; Hung, Kuan‐Yu; Chen, Huei‐Wen

doi:10.1161/atvbaha.117.309566

Cited by 55 publications

(47 citation statements)

References 44 publications

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“…MiR‐125b is no exception in this perspective. During our systematic literature search, we identified 12 articles examining the diagnostic utility of miR‐125b in different types of cardiovascular diseases, with the first report published 5 years ago (Table ) . Among these diseases, we found that coronary artery disease/coronary events (n = 4) and acute stroke (n = 3) are the most common diseases in which the role of circulating miR‐125b has been investigated, followed by intracranial aneurysms (n = 2), abdominal aortic aneurysm (n = 1), heart failure (n = 1) and VC (n = 1) (Table ).…”

Section: Microrna‐125b: a Potential Biomarker For Vascular Diseasesmentioning

confidence: 99%

MicroRNA‐125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications

Chao

Yeh

Yuan

et al. 2019

J Cellular Molecular Medi

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Epigenetic changes, particularly non‐coding RNAs, have been implicated extensively in the pathogenesis of vascular diseases. Specific miRNAs are involved in the differentiation, phenotypic switch, proliferation, apoptosis, cytokine production and matrix deposition of endothelial cells and/or vascular smooth muscle cells. MicroRNA‐125b has been studied in depth for its role in carcinogenesis with a double‐edged role; that is, it can act as an oncogene in some cancer types and as a tumour suppressor gene in others. However, cumulative evidence from the use of advanced miRNA profiling techniques and bioinformatics analysis suggests that miR‐125b can be a potential mediator and useful marker of vascular diseases. Currently, the exact role of miR‐125b in vascular diseases is not known. In this systematic review, we intend to provide an updated compilation of all the recent findings of miR‐125b in vascular diseases, using a systematic approach of retrieving data from all available reports followed by data summarization. MiR‐125b serves as a pathogenic player in multiple vascular pathologies involving endothelia and vascular smooth muscle cells and also serves as a diagnostic marker for vascular diseases. We further provide a computational biologic presentation of the complex network of miR‐125b and its target genes within the scope of vascular diseases.

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Section: Microrna‐125b: a Potential Biomarker For Vascular Diseasesmentioning

confidence: 99%

MicroRNA‐125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications

Chao

Yeh

Yuan

et al. 2019

J Cellular Molecular Medi

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“…In vascular tissues, miR-125b over-expression leads to a lower degree of endothelial and VSMC proliferation, more vaso-relaxation, but a greater severity of inflammation, as summarized in a prior systematic review [83]. In terms of its effect on VC, the up-regulation of miR-125b is associated with less calcium deposition by murine and human VSMCs by directly repressing Ets-1 and osterix, an important osteoblastic marker [13,22]; furthermore, our previous work demonstrated that higher VC severity among uremic patients correlates with lower circulating miR-125b levels, supporting its anti-VC effect and its clinical applicability [33].…”

Section: Negative Vc-regulating Mirnasmentioning

confidence: 74%

The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective

Hou

Yuan

et al. 2020

IJMS

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Vascular calcification (VC) is an important complication among patients of advanced age, those with chronic kidney disease, and those with diabetes mellitus. The pathophysiology of VC encompasses passive occurrence of physico-chemical calcium deposition, active cellular secretion of osteoid matrix upon exposure to metabolically noxious stimuli, or a variable combination of both processes. Epigenetic alterations have been shown to participate in this complex environment, through mechanisms including DNA methylation, non-coding RNAs, histone modifications, and chromatin changes. Despite such importance, existing reviews fail to provide a comprehensive view of all relevant reports addressing epigenetic processes in VC, and cross-talk between different epigenetic machineries is rarely examined. We conducted a systematic review based on PUBMED and MEDLINE databases up to 30 September 2019, to identify clinical, translational, and experimental reports addressing epigenetic processes in VC; we retrieved 66 original studies, among which 60.6% looked into the pathogenic role of non-coding RNA, followed by DNA methylation (12.1%), histone modification (9.1%), and chromatin changes (4.5%). Nine (13.6%) reports examined the discrepancy of epigenetic signatures between subjects or tissues with and without VC, supporting their applicability as biomarkers. Assisted by bioinformatic analyses blending in each epigenetic component, we discovered prominent interactions between microRNAs, DNA methylation, and histone modification regarding potential influences on VC risk.

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“…Among these VC-related miRNAs, miR-125b is an important example; circulating miR-125b levels reportedly predict the clinical course of VC in patients with CKD. 4,5 Judging from the importance of miR-125b in vascular pathologies shown by a prior review 6 and its readiness for assay, measuring circulating miR-125b levels for vascular risk estimation may bear high clinical utility. However, determinants of circulating miR-125b levels remain unclear.…”

Section: Dear Editormentioning

confidence: 99%

Determinants of circulating microRNA‐125b, a risk predictor of vascular calcification, among community‐dwelling older adults^*

Chao

Yeh

Han

et al. 2020

Clinical & Translational Med

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Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification

Abstract: The results suggest that serum miR-125b levels are associated with VC severity and serve as a novel predictive marker for the risk of uremia-associated calcification progression.

Cited by 55 publications

References 44 publications

MicroRNA‐125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications

MicroRNA‐125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications

The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective

Determinants of circulating microRNA‐125b, a risk predictor of vascular calcification, among community‐dwelling older adults^*

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Circulating MicroRNA-125b Predicts the Presence and Progression of Uremic Vascular Calcification

Abstract: The results suggest that serum miR-125b levels are associated with VC severity and serve as a novel predictive marker for the risk of uremia-associated calcification progression.

Cited by 55 publications

References 44 publications

MicroRNA‐125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications

MicroRNA‐125b in vascular diseases: An updated systematic review of pathogenetic implications and clinical applications

The Epigenetic Landscape of Vascular Calcification: An Integrative Perspective

Determinants of circulating microRNA‐125b, a risk predictor of vascular calcification, among community‐dwelling older adults*

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Determinants of circulating microRNA‐125b, a risk predictor of vascular calcification, among community‐dwelling older adults^*