Circulating mi<scp>RNA</scp> expression analysis reveals new potential biomarkers for human cutaneous melanoma staging

Sánchez‐Sendra, Beatriz; García‐Giménez, José Luis; González-Muñoz, José F.; Navarro, Lara; Murgui, Amelia; Terrádez, Liria; Pinazo, Isabel; Martín, J.M.; Monteagudo, Carlos

doi:10.1111/jdv.16060

Cited by 9 publications

(10 citation statements)

References 10 publications

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“…MiRNAs have been confirmed to play important roles in the occurrence of EC. [19][20][21] In this research, we found that the downregulation of miR-7-5p could notably suppress the growth of EC cells. Our study firstly explored the role of miR-7-5p in EC.…”

Section: Discussionmentioning

confidence: 57%

<p>Downregulation of miR-7-5p Inhibits the Tumorigenesis of Esophagus Cancer via Targeting KLF4</p>

Shi¹,

Song²,

Gao³

et al. 2020

OTT

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Background: Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with bioinformatics tool. Methods: The differential expression of miRNAs between EC and adjacent normal tissues was analyzed. CCK-8 and Ki67 staining were used to detect the cell proliferation. Flow cytometry was performed to test the cell apoptosis. The correlation between miR-7-5p and KLF4 was detected by dual-luciferase report assay. Gene and protein expression in EC cells or in tissues were measured by qRT-PCR and Western blot, respectively. Cell migration and invasion were detected with transwell assay. Xenograft mice model was established to investigate the role of miR-7-5p in EC tumorigenesis in vivo. Results: MiR-7-5p was found to be negatively correlated with the survival rate of patient with EC. In addition, downregulation of miR-7-5p significantly inhibited the growth and invasion of EC cells. Meanwhile, miR-7-5p directly targeted KLF4 in EC cells. Moreover, downregulation of miR-7-5p inhibited the tumorigenesis of EC via inactivating MAPK signaling pathway in vivo. Conclusion: Downregulation of miR-7-5p notably suppressed the progression of EC via targeting KLF4. Thus, miR-7-5p might serve as a new target for the treatment of EC.

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Section: Discussionmentioning

confidence: 57%

<p>Downregulation of miR-7-5p Inhibits the Tumorigenesis of Esophagus Cancer via Targeting KLF4</p>

Shi¹,

Song²,

Gao³

et al. 2020

OTT

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“…In our data, patients with stage IB, IIA and IIB had higher levels of miR-199a-5p (fold change % 6) than IA patients; and in comparison with the latter the fold change was even higher in stage III patients (fold change % 10). miR-199a-5p diagnostic potential was previously supported by Leidinger et al 10 who found miR-199a-5p overexpression in blood cells of melanoma patients compared with healthy controls.…”

mentioning

confidence: 63%

Non‐contact remote digital dermoscopy – new perspectives on differential diagnosis of inflammatory skin diseases

Heratizadeh

Fricke

Meinhardt‐Wollweber

et al. 2019

Acad Dermatol Venereol

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“…miR-199a-5p promotes melanoma metastasis and angiogenesis, and has been shown to be up-regulated 10-fold in patients with stage III melanoma compared to stage Ia disease ( 47 ). Even patients with stage Ib to IIb disease had a 6-fold increase in expression compared to healthy and stage Ia groups ( 47 , 48 ).…”

Section: Molecular Profilingmentioning

confidence: 99%

Current Trends in Circulating Biomarkers for Melanoma Detection

2022

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Melanomas have increased in global incidence and are the leading cause of skin cancer deaths. Whilst the majority of early-stage, non-metastatic melanomas can be cured with surgical excision alone, ~5% of patients with early melanomas will experience recurrence following a variable disease-free interval and progression to metastatic melanoma and ultimately death. This is likely because of primary tumor heterogeneity and progressive clonal divergency resulting in the growth of more aggressive tumor populations. Liquid biomarkers have the advantage of real-time, non-invasive longitudinal monitoring of tumor burden and heterogeneity over tissue markers. Currently, the only serological marker used in the staging and monitoring of melanoma is serum lactate dehydrogenase, which is not sufficiently specific or sensitive, and is not used routinely in all centers. An ideal melanoma biomarker would be used to identify patients who are at high-risk of primary melanoma, screen for relapse, detect early-stage melanoma, provide treatment outcomes to personalize systemic treatment, follow tumor heterogeneity, provide prognostic data before, during and after treatment, and monitor response to treatment. This review provides a summary of the current research in this field with a specific focus on circulating tumor cells, circulating tumor DNA, microRNA, and extracellular vesicles which may serve to suit these goals.

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Circulating miRNA expression analysis reveals new potential biomarkers for human cutaneous melanoma staging

Cited by 9 publications

References 10 publications

<p>Downregulation of miR-7-5p Inhibits the Tumorigenesis of Esophagus Cancer via Targeting KLF4</p>

<p>Downregulation of miR-7-5p Inhibits the Tumorigenesis of Esophagus Cancer via Targeting KLF4</p>

Non‐contact remote digital dermoscopy – new perspectives on differential diagnosis of inflammatory skin diseases

Current Trends in Circulating Biomarkers for Melanoma Detection

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