Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: Results of a pilot biomonitoring study

Foster, Warren G.; Cheung, Anthony P.; Davis, Karelyn; Graves, Gillian; Jarrell, J.; LeBlanc, Alain; Liang, Chun Lei; Leech, Tara; Walker, Mark; Weber, Jean-Philippe; Oostdam, Jay Van

doi:10.1016/j.scitotenv.2012.06.070

Cited by 37 publications

(36 citation statements)

References 66 publications

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“…Prior to GC-MS, plasma samples were extracted on a solid phase extraction (SPE) column, then purified on a Florisil column and concentrated to a final volume. Reported previously (Foster et al, 2012), analyte concentrations were evaluated by considering the % recovery of labeled internal standards. The INSPQ participates in two interlaboratory comparison programs to verify the accuracy of results, in addition to routine analysis of reference serum supplied by the US National Institute of Science and Technology.…”

Section: Study Descriptionmentioning

confidence: 99%

Assessing determinants of maternal blood concentrations for persistent organic pollutants and metals in the eastern and western Canadian Arctic

Curren

Liang

Davis

et al. 2015

Science of The Total Environment

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Aboriginal peoples in the Canadian Arctic are exposed to persistent organic pollutants (POPs) and metals mainly through their consumption of a traditional diet of wildlife items. Recent studies indicate that many human chemical levels have decreased in the north, likely due to a combination of reduced global chemical emissions, dietary shifts, and risk mitigation efforts by local health authorities. Body burdens for chemicals in mothers can be further offset by breastfeeding, parity, and other maternal characteristics. We have assessed the impact of several dietary and maternal covariates following a decade of awareness of the contaminant issue in northern Canada, by performing multiple stepwise linear regression analyses from blood concentrations and demographic variables for 176 mothers recruited from Nunavut and the Northwest Territories during the period 2005-2007. A significant aboriginal group effect was observed for the modeled chemicals, except for lead and cadmium, after adjusting for covariates. Further, blood concentrations for POPs and metals were significantly associated with at least one covariate of older age, fewer months spent breastfeeding, more frequent eating of traditional foods, or smoking during pregnancy. Cadmium had the highest explained variance (72.5%) from just two significant covariates (current smoking status and parity). Although Inuit participants from the Northwest Territories consumed more traditional foods in general, Inuit participants from coastal communities in Nunavut continued to demonstrate higher adjusted blood concentrations for POPs and metals examined here. While this is due in part to a higher prevalence of marine mammals in the eastern Arctic diet, it is possible that other aboriginal group effects unrelated to diet may also contribute to elevated chemical body burdens in Canadian Arctic populations.

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Section: Study Descriptionmentioning

confidence: 99%

Assessing determinants of maternal blood concentrations for persistent organic pollutants and metals in the eastern and western Canadian Arctic

Curren

Liang

Davis

et al. 2015

Science of The Total Environment

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“…Two recent papers have reported the analysis of data from this CEC study for Canada (Foster et al, 2012) and Mexico (Rodriguez-Dozal et al, 2012). In each case the analysis was restricted to comparisons between sites or regions within each country.…”

Section: Discussionmentioning

confidence: 99%

“…These sites represent a mix of cities with different histories of industrial activity, agricultural practices and use of pesticides, types of employment, and also represent different geographic regions of each country (Foster et al, 2012; Rodriguez-Dozal et al, 2012). Primiparous women were recruited until the goal of twenty-five women from each of the sites was reached.…”

Section: Methodsmentioning

confidence: 99%

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Persistent organic pollutants (POPs) and metals in primiparous women: a comparison from Canada and Mexico

Adlard

Davis

Liang

et al. 2014

Science of The Total Environment

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Under the North American Commission for Environmental Cooperation (CEC) and its Sound Management of Chemicals (SMOC) program, a tri-national human contaminant monitoring initiative was completed to provide baseline exposure information for several environmental contaminants in Canada, Mexico and the United States (U.S). Blood samples were collected from primiparous women in Canada and Mexico, and were analysed for a suite of environmental contaminants including polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene(p,p′-DDE),beta-hexachlorocyclohexane (β-HCH), mercury and lead. A multiple stepwise linear regression analysis was conducted using data from Canadian and Mexican primiparous mothers, adjusting for ethnicity group, age, pre-pregnancy BMI, years at current city and ever-smoking status. Concentrations of p,p′-DDE, β-HCH, and lead were found to be higher among Mexican participants; however, concentrations of most PCBs among Mexican participants were similar to Canadian primiparous women after adjusting for covariates. Concentrations of total mercury were generally higher among Mexican primiparous women although this difference was smaller as age increased. This initial dataset can be used to determine priorities for future activities and to track progress in the management of the selected chemicals, both domestically and on a broader cooperative basis within North America.

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“…Because of their persistent and bioaccumulative characters, OCs occur and accumulate in wildlife (Gelsleichter et al, 2005;Nakata et al, 2005;Moon et al, 2010) and humans (Bergonzi et al, 2009;Lee et al, 2013). PCBs and OCPs have adverse health effects such as developmental toxicity, cancer, and endocrine disruption (Beard, 2006;Foster et al, 2012). PCBs and OCPs are regulated by the Stockholm Convention as persistent organic pollutants (POPs) by the United Nations Environment Programme (UNEP) since 2001 (Fielder et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Persistent organochlorines in 13 shark species from offshore and coastal waters of Korea: Species-specific accumulation and contributing factors

Lee

Jeong

Lee

et al. 2015

Ecotoxicology and Environmental Safety

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Circulating metals and persistent organic pollutant concentrations in Canadian and non-Canadian born primiparous women from five Canadian centres: Results of a pilot biomonitoring study

Cited by 37 publications

References 66 publications

Assessing determinants of maternal blood concentrations for persistent organic pollutants and metals in the eastern and western Canadian Arctic

Assessing determinants of maternal blood concentrations for persistent organic pollutants and metals in the eastern and western Canadian Arctic

Persistent organic pollutants (POPs) and metals in primiparous women: a comparison from Canada and Mexico

Persistent organochlorines in 13 shark species from offshore and coastal waters of Korea: Species-specific accumulation and contributing factors

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