Circulating metabolome landscape in Lynch syndrome
Tiina A. Jokela,
Jari E. Karppinen,
Minta Kärkkäinen
et al.
Abstract:Circulating metabolites systemically reflect cellular processes and can modulate the tissue microenvironment in complex ways, potentially impacting cancer initiation processes. Genetic background increases cancer risk in individuals with Lynch syndrome; however, not all carriers develop cancer. Various lifestyle factors can influence Lynch syndrome cancer risk, and lifestyle choices actively shape systemic metabolism, with circulating metabolites potentially serving as the mechanical link between lifestyle and… Show more
“…In consensus with our findings, a previous study has shown serum metabolites of non-tumor LS subjects were similar to sporadic CRC, with elevated inflammatory markers. 72 …”
“…In consensus with our findings, a previous study has shown serum metabolites of non-tumor LS subjects were similar to sporadic CRC, with elevated inflammatory markers. 72 …”
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