Circulating metabolites are associated with persistent elevations of ALT in patients with chronic hepatitis B with complete viral suppression
Dekai Zheng,
Changhao Cheng,
Yanhua Tang
et al.
Abstract:Hepatitis B virus (HBV) can be completely suppressed after antiviral treatment; however, some patients with chronic hepatitis B (CHB) exhibit elevated alanine aminotransferase (ALT) levels and sustained disease progression. This study provides novel insights into the mechanism and potential predictive biomarkers of persistently elevated ALT (PeALT) in patients with CHB after complete viral inhibition. Patients having CHB with undetectable HBV DNA at least 12 months after antiviral treatment were enrolled from … Show more
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