Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention

Morawin, Barbara; Tylutka, Anna; Chmielowiec, Jolanta; Zembroń-Łacny, Agnieszka

doi:10.3390/ijerph18063165

Cited by 18 publications

(17 citation statements)

References 78 publications

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“…Earlier, we investigated the relationship between lifestyle exercise and percentage of CD4+ and CD8+ naïve and memory T lymphocytes as well as CD4/CD8 ratio in active compared to inactive older individuals [19]. Furthermore, we also analysed changes in inflammatory pattern in response to physical exercise intervention [22]. In the present study, we focused on the profile of circulating pro-and anti-inflammatory mediators in conjunction with nutritional status and physical performance resulting from daily activity.…”

Section: Discussionmentioning

confidence: 99%

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The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

et al. 2021

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One of the latest theories on ageing focuses on immune response, and considers the activation of subclinical and chronic inflammation. The study was designed to explain whether anti-inflammatory diet and lifestyle exercise affect an inflammatory profile in the Polish elderly population. Sixty individuals (80.2 ± 7.9 years) were allocated to a low-grade inflammation (LGI n = 33) or high-grade inflammation (HGI n = 27) group, based on C-reactive protein concentration (<3 or ≥3 mg/L) as a conventional marker of systemic inflammation. Diet analysis focused on vitamins D, C, E, A, β-carotene, n-3 and n-6 PUFA using single 24-h dietary recall. LGI demonstrated a lower n-6/n-3 PUFA but higher vitamin D intake than HGI. Physical performance based on 6-min walk test (6MWT) classified the elderly as physically inactive, whereby LGI demonstrated a significantly higher gait speed (1.09 ± 0.26 m/s) than HGI (0.72 ± 0.28 m/s). Circulating interleukins IL-1β, IL-6, IL-13, TNFα and cfDNA demonstrated high concentrations in the elderly with low 6MWT, confirming an impairment of physical performance by persistent systemic inflammation. These findings reveal that increased intake of anti-inflammatory diet ingredients and physical activity sustained throughout life attenuate progression of inflammaging in the elderly and indicate potential therapeutic strategies to counteract pathophysiological effects of ageing.

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Section: Discussionmentioning

confidence: 99%

“…They were asked to avoid heavy physical exertion and to avoid consuming drinks for 3 h before the test. The measurements were made in accordance with the procedure previously used in the elderly [22].…”

Section: Body Compositionmentioning

confidence: 99%

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

et al. 2021

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“…It may be beneficial to incorporate mind–body exercises into such interventions such as Tai-chi. Indeed, literature has shown that such exercises can significantly reduce sarcopenia symptoms [ 30 ] and improve QoL per se [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia reduces quality of life in the long-term: longitudinal analyses from the English longitudinal study of ageing

et al. 2022

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Purpose Mixed findings exist for sarcopenia/quality of life (QoL) relationship. Moreover, the majority of studies in this area have utilized a cross-sectional design or specific clinical populations. Therefore, the aim of the present study was to examine the association between sarcopenia at baseline and QoL at 10 years follow-up in a large representative sample of older English adults. Methods Sarcopenia was diagnosed as having low handgrip strength and low skeletal muscle mass index. QoL was measured using the CASP (control, autonomy, self-realisation and pleasure)-19, with higher values reflecting higher QoL. Multivariable logistic regression analysis was conducted to assess prospective associations between sarcopenia at baseline and poor QoL at follow-up; generalized linear model with repeated measures was used for reporting mean changes during follow-up between sarcopenia and not. Results Among 4044 older participants initially included at baseline (mean age: 70.7 years; 55.1% females), 376 had sarcopenia. In the multivariable analysis, after adjusting for several potential confounders, sarcopenia at baseline was associated with a higher incidence of poor QoL (odds ratio, OR = 5.82; 95% confidence interval, CI 3.45–9.82). After matching for QoL values at baseline and adjusting for potential confounders, people with sarcopenia reported significantly lower values in CASP-19 (mean difference = − 3.94; 95% CI − 4.77 to − 3.10). Conclusions In this large representative sample of older English adults, it was observed that sarcopenia at baseline was associated with worse scores of QoL at follow-up compared to those without sarcopenia at baseline. It may be prudent to target those with sarcopenia to improve QoL.

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“…Regular moderate physical activity has been reported to prevent and treat age-related degeneration [ 40 , 41 ]. From a physiological point of view, exercise reduces sarcopenia by decreasing inflammation [ 42 ]. In addition, it increases anabolism [ 43 ], protein synthesis [ 44 ], mitochondrial remodelling [ 45 , 46 ], and the appearance of fibro–adipogenic progenitors in response to exercise-induced muscle damage, allowing regenerative inflammation to improve muscle endurance [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic Assessment of Left Ventricular Function 10 Years after the Ultra-Endurance Running Event Eco-Trail de Paris® 2011

Jouffroy

Benaceur

Toussaint

et al. 2022

IJERPH

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Background: Regular and moderate physical activity is beneficial for physical and mental health, resulting in an increase in life expectancy for both sexes. From a cardiovascular point of view, although the benefits of regular moderate physical exercise have been established, the long-term effects of repeated ultra-endurance running events are still unknown. Hypothesis: The aim of our study is to evaluate the 10-year evolution of the parameters of the left ventricular systolic and diastolic functions of amateur subjects regularly practising ultra-endurance running events using resting echocardiography. Study design: Cross-sectional study. Level of evidence: Level 3—non-randomized controlled cohort/follow-up study. Methods: The 66 participants who participated in the 2011 edition of the Eco-Trail de Paris® were contacted by e-mail. Demographic data, sports practice, and the results of an echocardiography scan carried out during the year 2021 evaluating left ventricular systolic and diastolic function variables were collected. Echographic variables from 2011 and 2021 were compared using the paired Student’s t-test. Results: Forty-six (70%) participants responded positively. Twenty (30%) participants could not be reached and were not analysed. Of the 46 respondents, 42 (91%) provided data from a trans-thoracic cardiac ultrasound performed in 2021. Over the past 10 years, the participants reported having completed an average of 4 ± 2 ultra-trails per year. No significant differences were observed between left ventricular diastolic and systolic echocardiographic parameters between the years 2011 and 2021. Conclusions: Among amateur participants, long-distance running is not associated with an alteration in the echocardiographic parameters of resting left ventricular systolic and diastolic function after 10 years of practice. Clinical relevance: Long-term long-distance running practice is not associated with left ventricular cardiac function alteration. These results suggest a potential adaptation role of the cardiovascular system to regular and moderate long-distance running practice.

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Circulating Mediators of Apoptosis and Inflammation in Aging; Physical Exercise Intervention

Cited by 18 publications

References 78 publications

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

Sarcopenia reduces quality of life in the long-term: longitudinal analyses from the English longitudinal study of ageing

Echocardiographic Assessment of Left Ventricular Function 10 Years after the Ultra-Endurance Running Event Eco-Trail de Paris® 2011

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