Circulating maternal cytokines influence fetal growth in pregnant women with rheumatoid arthritis

Abstract

Maternal IL-10 and IL-6 levels are associated with fetal growth in RA. In the first trimester, high IL-10 levels are associated with higher birth weight SDS, and high IL-6 levels are associated with lower birth weight SDS, even after correction for disease activity.

Correlation of Tumor Necrosis Factor Alpha, Interleukin 6 and Interleukin 10 With Blood Pressure, Risk of Preeclampsia and Low Birth Weight in Gestational Diabetes

“…The elevation of TNF-α was perceived as a phenomenon specific for IUGR with placental dysfunction. De Steenwinkel et al (2013) provided evidence of association between elevation of IL-6 and low birth weight in mothers with rheumatoid arthritis. A majority of literature shows the protective effect of IL-10 on fetoplacetal unit (amongst other, by inhibition of secretion of proinflammatory cytokines IL-6, TNF-α, interferon gamma) (Tinsley et al 2010).…”

“…Elevated levels of cytokines can be the cause of placental dysfunction, which may result in intrauterine growth restriction (IUGR) or premature birth (PTB) (Challis et al 2009). De Steenwinkel et al (2013) proposed a hypothesis, that the levels of maternal cytokines can significantly influence the growth of the fetus in women with rheumatoid arthritis (RA). They proved, that in the mother's serum during the first trimester, increased levels of interleukin 10 (IL-10) are associated with higher birth weight, and increased levels of interleukin 6 (IL-6) are associated with lower birth weight (De Steenwinkel et al 2013).…”

“…De Steenwinkel et al (2013) proposed a hypothesis, that the levels of maternal cytokines can significantly influence the growth of the fetus in women with rheumatoid arthritis (RA). They proved, that in the mother's serum during the first trimester, increased levels of interleukin 10 (IL-10) are associated with higher birth weight, and increased levels of interleukin 6 (IL-6) are associated with lower birth weight (De Steenwinkel et al 2013). In studies on pregnant women, it has been proven that both TNF-α and IL-6 induce structural and functional changes of endothelial cells.…”

Challenges and treatment options for rheumatoid arthritis during pregnancy

“…Likewise, high disease activity has been associated with lower birth weight [10][11][12]. Recently, de Steenwinkle et al have demonstrated that high levels of circulating IL-6 (a pro-inflammatory cytokine) in the first trimester were associated with lower birth weight [13].…”

Interleukin-6 acts locally on the growth plate to impair bone growth

“…A recent clinical study in mothers with rheumatoid arthritis (RA) published in this journal reported that high maternal serum levels of interleukin-6 (IL-6) are associated with low birthweight deliveries 1. Low birth weight in turn is associated with impaired growth during childhood 2.…”