Circulating markers of free radical activity in patients with pulmonary tuberculosis

Jack, Cia; Jackson, Malcolm J.; Hind, C. R. K.

doi:10.1016/0962-8479(94)90042-6

Cited by 53 publications

(41 citation statements)

References 10 publications

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“…The high level (P ≤ 0.05) of MDA in the HIV-TB co-infection compared with the HIV patients on HAART could be as a result of increased ROS in HIV and TB infections as previously reported in patients with HIV and TB [31][32][33][34]. This may further support a role for oxidative stress in the pathogenesis of HIV and TB patients and subsequently suggest a higher rate of viral multiplication and oxidative stress in naive patients as shown in this study.…”

Section: Discussionmentioning

confidence: 49%

“…Viral Tat protein induces an enhanced ROS production in HIV-infected patients by mitochondrial generation of superoxide anion [9], which in turn may activate nuclear factor κB (NF-κB) [8], thus increasing HIV transcription. Oxidative stress also has been shown to be associated with TB infection through activation of phagocytes by mycobacteria which may further contribute to immunosuppression [10,11]. Furthermore, an earlier report [12] has shown high levels of oxidative stress in HIV-TB co-infected patients.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Awodele

Olayemi

Nwite

et al. 2011

J Infect Dev Ctries

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Introduction: Among opportunistic pathogens associated with acquired immunodeficiency syndrome (AIDS), Mycobacterium tuberculosis is distinguished by its relative virulence and potential for person-to-person transmission. Oxidative stress is associated with TB infection with a high level in patients with HIV-TB co-infection. However, the comparative level of oxidative stress in HIV patients on highly active antiretroviral therapy (HAART) and naïve (untreated) HIV patients is not clear. Methodology: This study is aimed to determine the level of oxidative stress and haematological parameters in HIV patients (naïve), HIV patients undergoing HAART, and HIV-TB co-infected patients. In total, 100 consenting subjects were recruited from the AIDS Prevention Iniative in Nigeria (APIN) Clinic. For controls, normal male healthy volunteers were recruited from the blood donor clinic and females from the APIN clinic staff members, both of the Lagos University Teaching Hospital. Measurements of antioxidant enzyme activity and lipid peroxidation were performed according to standard procedures. Haematological parameters were determined using a fully automated hematology analyzer. Results: Red blood cells significantly decreased (P≤0.001) in all patients when compared with control subjects. The lipid peroxidation (MDA) was significantly high (P≤0.05) in naive patients when compared to HIV patients on HAART. The decrease in the levels of GSH in both naive and HIV-TB co-infected patients (P≤0.001) and HIV patients on HAART (P<0.05) were significant when compared to control patients. Conclusion: There is lower antioxidant level and higher MDA in naive and HIV-TB co-infected patients as compared to HIV patients on HAART and the seronegative patients.

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Section: Discussionmentioning

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Awodele

Olayemi

Nwite

et al. 2011

J Infect Dev Ctries

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“…The enhanced level of free radical production, although designed to combat the invader, has the potential to damage the host; however, host tissue damage is limited by the concurrent enhancement of the antioxidant defenses of the host [5]. In tuberculosis patients, there are also some reports of poor antioxidants defence that may expose to oxidative host tissue damage [6] [7].…”

Section: Mycobacteria Tuberculosis and The Antioxidant Defense Mechanmentioning

confidence: 99%

The Non-Enzymatic Antioxidant and Level of Oxidative Stress of Tuberculosis Patients in Selected Treatment Center in Addis Ababa Ethiopia

Gebretsadik¹,

Seifu²,

Yimer³

et al. 2015

JTR

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“…This further contributes to immunosuppression (Jack et al, 1994;Grimble, 1994). Moreover the malnutrition that commonly occurred in patients with tuberculosis may further contribute to the impaired anti-oxidant capacity in these patients.…”

Section: Introductionmentioning

confidence: 99%

Oxidative metabolic changes in pleural fluid of tuberculosis patients

Reddy

Doreswamy

Krishna

et al. 2008

Bangladesh J Pharmacol

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The pleural fluid was aspirated from the tuberculous patients both untreated and under treatment with three months anti-tuberculosis therapy. The amount of malondialdehyde, lactate dehydrogenase, and total protein content in pleural fluid of untreated tuberculous patients were found to be significantly higher when compared with under treatment group. The pleural fluid total anti-oxidant levels were significantly lower in untreated cases in comparison to under treatment. Decrease in the total anti-oxidant status was more pronounced in untreated cases, established that anti-oxidants were nearly completely utilized to scavenge the free radicals. Our findings further support the importance of anti-oxidants in the treatment of tuberculous patient.

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Circulating markers of free radical activity in patients with pulmonary tuberculosis

Cited by 53 publications

References 10 publications

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

Investigation of the levels of oxidative stress parameters in HIV and HIV-TB co-infected patients

The Non-Enzymatic Antioxidant and Level of Oxidative Stress of Tuberculosis Patients in Selected Treatment Center in Addis Ababa Ethiopia

Oxidative metabolic changes in pleural fluid of tuberculosis patients

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