Circulating malignant precursors in monoclonal gammopathies

Caligaris-Cappio, Federico; Bergui, Luciana; Gaïdano, Gianluca; Schena, Marina; Putto, P.; Merico, F.; Riva, M.

doi:10.1111/j.1600-0609.1989.tb01488.x

Cited by 7 publications

(1 citation statement)

References 18 publications

(9 reference statements)

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“…Abnormalities in the expression and function of cell adhesion molecules may account for the patterns of intranodal growth and hematogenous spread of the malignant cells (1,2). Chemokine-and integrin-mediated adhesion and transendothelial migration (TEM) are central aspects in trafficking and retention of hematopoietic cells in the BM and lymphoid organs.…”

Section: B-cell Chronic Lymphocytic Leukemia (Cll) Is Marked By the Amentioning

confidence: 99%

Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow

et al. 2009

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Homing to secondary lymphoid organs and bone marrow (BM) is a central aspect of leukemic pathophysiology. We investigated the roles of the two major lymphocyte integrins LFA-1 and VLA-4 on B-cell chronic lymphocytic leukemia (CLL) cells in these processes. We found that the majority of CLL cells expressed significantly reduced LFA-1 due to low B2 integrin transcripts. VLA-4 expression was heterogenous but underwent rapid activation by the BM chemokine CXCL12. CLL cells failed to transmigrate across VCAM-1-expressing, ICAM-1-expressing, and CXCL12-expressing endothelium, whereas when LFA-1 expression was regained in subsets of CLL cells, these lymphocytes rapidly transmigrated the endothelium. Furthermore, when injected into tail veins of immunodeficient mice, normal B cells rapidly homed to lymph nodes (LN) in a LFA-1-dependent manner, whereas CLL cells did not. Nevertheless, only residual CLL subsets could reenter BM, whereas both normal and CLL cells homed to the mice spleen in an LFA-1-independent and VLA-4-independent manner. Our results suggest that CLL cells have a reduced capacity to adhere and transmigrate through multiple vascular endothelial beds and poorly home to lymphoid organs other than spleen. Integrin blocking could thus be an efficient strategy to prevent circulating CLL cells from reaching prosurvival niches in LNs and BM but not in spleen.

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Section: B-cell Chronic Lymphocytic Leukemia (Cll) Is Marked By the Amentioning

confidence: 99%

Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow

et al. 2009

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Primary plasmacytoma at the site of exit wounds after electrical injury

et al. 1998

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We report a case of primary plasmacytoma occurring 12 years after electrical injury. Roentgenograms showed multiple well-circumscribed lytic lesions involving both the right and left tibial diaphyseal regions. Bone biopsy from the left tibial region showed sheets of monoclonal myeloma cells. No evidence of multiple myeloma was found. The patient was treated with local radiation to both tibias and had no evidence of recurrence 6 years later. In conclusion, we report the first case of primary plasmacytoma of both tibias that occurred after electrical injury 12 years before. Am.

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Autologous blood stem cell transplantation in myeloma

Bell

1990

Transfusion Science

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Circulating malignant precursors in monoclonal gammopathies

Cited by 7 publications

References 18 publications

Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow

Circulating B-Cell Chronic Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone Marrow

Primary plasmacytoma at the site of exit wounds after electrical injury

Autologous blood stem cell transplantation in myeloma

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