Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation

Groeneweg, Koen E.; Duijs, Jacques M.G.J.; Florijn, Barend W.; Kooten, Cees van; Fijter, Johan W. de; Zonneveld, Anton Jan van; Reinders, Marlies E.J.; Bijkerk, Roel

doi:10.3390/ijms21165616

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…The loss of the microvasculature, also referred to as microvascular rarefaction, is a critical determinant in kidney disease states such as acute kidney failure, diabetic nephropathy or kidney transplant rejection (53). The resulting ischaemia is a driver for an inflammatory This article is protected by copyright.…”

Section: Kidney: the Coagulome In Kidney Diseasementioning

confidence: 99%

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis

et al. 2023

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The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The “coagulome” as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.

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Section: Kidney: the Coagulome In Kidney Diseasementioning

confidence: 99%

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis

et al. 2023

Self Cite

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“…Therefore, measuring the levels of dmtDNA could be a valuable method for predicting acute rejection in individuals who have undergone kidney transplantation. In a study by Groeneweg et al [ 70 ], the influence of acute rejection (AR) on local vascular integrity was examined in 47 kidney-transplant recipients by analyzing kidney biopsies. The researchers observed a reduction in capillary density during AR.…”

Section: Genetic Markersmentioning

confidence: 99%

Biomarkers for Kidney-Transplant Rejection: A Short Review Study

Sharaby,

Alksas,

Abou El-Ghar

et al. 2023

Biomedicines

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Kidney transplantation is the preferred treatment for end-stage renal failure, but the limited availability of donors and the risk of immune rejection pose significant challenges. Early detection of acute renal rejection is a critical step to increasing the lifespan of the transplanted kidney. Investigating the clinical, genetic, and histopathological markers correlated to acute renal rejection, as well as finding noninvasive markers for early detection, is urgently needed. It is also crucial to identify which markers are associated with different types of acute renal rejection to manage treatment effectively. This short review summarizes recent studies that investigated various markers, including genomics, histopathology, and clinical markers, to differentiate between different types of acute kidney rejection. Our review identifies the markers that can aid in the early detection of acute renal rejection, potentially leading to better treatment and prognosis for renal-transplant patients.

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“…For examples, circulating LNC-EPHA6 was con rmed as a promising marker for vascular injury under acute rejection after kidney transplantation [19]. Another study reported that lncRNA NEAT1 served as a sponge for miR-146b to regulate TRAF6 expression and NF-κB signaling, thus accelerating renal mesangial cell injury in lupus nephritis [20].…”

Section: Introductionmentioning

confidence: 99%

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in Henoch-Schönlein purpura nephritis of children

Huang

Xie

et al. 2022

Preprint

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Long noncoding RNAs (lncRNAs) play important roles in the regulation of immunological and apoptotic function. Here, we aimed to explore critical immune- and apoptosis-related lncRNAs in the occurrence and development of Henoch-Schönlein purpura nephritis (HSPN) in children. Through differentially expressed analysis, we identified differentially expressed lncRNAs, immune- and apoptosis-related mRNAs in the peripheral blood samples of children with HSPN. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses validated the immunological and apoptotic roles of the differentially expressed immune-related and apoptosis-related mRNAs. Following, we analyzed the correlations of differentially expressed lncRNAs and immune- and apoptosis-related mRNAs by Spearman’s correlation analysis, and determined 100 critical immune- and apoptosis-related lncRNAs in HSPN of children. Based on competing endogenous RNAs (ceRNA) mechanism, we constructed the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in HSPN of children, and validated the expression levels of lncRNAs in the lncRNA-miRNA-mRNA regulatory network. Collectively, we proposed that the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network might participate in the modulation of pathogenesis of HSPN in children. In addition, the lncRNAs in the immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network (upregulated SNHG3, LINC00152, TUG1, GAS5, FGD5-AS1, DLEU2, and SCARNA9; downregulated SNHG1, NEAT1, DISC1-IT1, and PVT1) could become novel biomarkers for the diagnosis of HNSP in children.

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Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation

Cited by 9 publications

References 26 publications

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis

Biomarkers for Kidney-Transplant Rejection: A Short Review Study

Integrated analysis of immune- and apoptosis-related lncRNA-miRNA-mRNA regulatory network in Henoch-Schönlein purpura nephritis of children

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