2000
DOI: 10.1016/s0272-6386(00)70297-6
|View full text |Cite
|
Sign up to set email alerts
|

Circulating levels of transforming growth Factor-β1 and lymphokines among children with hemolytic uremic syndrome

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

3
36
0

Year Published

2001
2001
2018
2018

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 29 publications
(39 citation statements)
references
References 23 publications
3
36
0
Order By: Relevance
“…Various circulating inflammatory mediators, including ILs, chemokines, soluble adhesion molecules, growth factors, cytokine receptors, and acute phase response proteins, are abnormally increased in children with D ϩ HUS (7,92,124,126,(135)(136)(137)(138)(139)(140)(141)(142)(143)(144)(145)(146)(147)(148). Although these studies do not prove that the elevated inflammatory mediators have a role in the pathogenesis of disease, they indicate a marked host inflammatory response.…”
Section: Host Responsementioning
confidence: 91%
See 1 more Smart Citation
“…Various circulating inflammatory mediators, including ILs, chemokines, soluble adhesion molecules, growth factors, cytokine receptors, and acute phase response proteins, are abnormally increased in children with D ϩ HUS (7,92,124,126,(135)(136)(137)(138)(139)(140)(141)(142)(143)(144)(145)(146)(147)(148). Although these studies do not prove that the elevated inflammatory mediators have a role in the pathogenesis of disease, they indicate a marked host inflammatory response.…”
Section: Host Responsementioning
confidence: 91%
“…Certain lymphokines such as IL-2, IL-4, and IL-13 were undetectable during E. coli O157:H7 enteritis or HUS, and low concentrations of interferon-␥ were comparable among children with hemorrhagic colitis and HUS and control subjects, suggesting that T lymphocytes are not activated (139). Decreased levels of soluble L-selectin were observed in children with HUS, perhaps reflecting the appearance of immature neutrophils in the circulation (135).…”
Section: Host Responsementioning
confidence: 98%
“…Measurements of G-CSF, ENA-78, GRO-␣, MIP-1␤, and MCP-1 were performed in duplicate on plasma by sandwich ELISA (R & D Systems, Minneapolis, MN, U.S.A.). Samples were diluted 1:2; G-CSF, 50 L; ENA-78, 25 L; GRO-␣, 100 L; MIP-1␤, 75 L; and MCP-1, 100 L. Standard curves were established for each microtiter plate and measurements were then performed as previously described (19,20,26). Plates were developed and the OD of the reaction mix was quantified with an automated ELISA reader.…”
Section: Methodsmentioning
confidence: 99%
“…Figure 4 shows that most patients with increased serum PCT presented 2-to 5-fold increased ALT levels. Finally, we noted that PCT was correlated with LPS-binding protein (n ϭ 22, R 2 ϭ 0.6; p Ͻ 0.0001) (25), but not other inflammatory mediators previously studied by us: (n ϭ 25-50, R 2 Ͻ 0.1, p ϭ NS, for: TNF-␣, IL-1␤, IL1-receptor antagonist, IFN-␥, IL-6, IL-8, IL-10, selectins-L, -P, -E, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, granulocyte colony-stimulating fac- tor, growth-related oncogene-␣, macrophage inflammatory protein-1␤, macrophage chemotactic protein-1, epithelial-cell derived neutrophil activating peptide-78, transforming growth factor-␤1, sFas, and mannan-binding lectin (18,(21)(22)(23)(24).…”
Section: Resultsmentioning
confidence: 99%
“…All statistical tests were two-sided. We performed linear regression analysis between concentrations of PCT, and age, time after the onset of enteritis, leukocyte counts, Hb levels, platelet counts, serum urea, creatinine, ALT levels, and inflammatory mediators (18,(21)(22)(23)(24), including LPS-binding protein (25).…”
Section: Methodsmentioning
confidence: 99%