Circulating Levels of Oxidative Stress Markers and Endothelial Adhesion Molecules in Men with Abdominal Obesity

Couillard, Charles; Ruel, Guillaume; Archer, W. Roodly; Pomerleau, Sonia; Bergeron, Jean; Couture, Patrick; Lamarche, Benoı̂t; Bergeron, Nathalie

doi:10.1210/jc.2004-2438

Cited by 173 publications

(122 citation statements)

References 42 publications

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“…Abdominal obesity was independently associated with ox-LDL [6,25], providing a link between ox-LDL and the metabolic syndrome [26]. A limitation of the present study is that waist circumference was not measured.…”

Section: Discussionmentioning

confidence: 75%

Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

et al. 2008

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Objective-The objective of this study was to determine whether total serum carotenoids, alphatocopherol, selenium, and obesity were independently associated with oxidized low-density lipoproteins (ox-LDL) in moderately to severe disabled older women living in the community.Methods-Serum ox-LDL, carotenoids, alpha-tocopherol, and selenium were measured in a population-based sample of 543 moderately to severely disabled women, aged 65 and older, in the Women's Health and Aging Study I in Baltimore, Maryland.Results-Total serum carotenoids, smoking, overweight (BMI 25-29.9 kg/m 2 ), and obesity (BMI≥30 mg/kg 2 ) were significantly associated with ox-LDL/LDL-cholesterol ratio after adjusting for age, C-reactive protein, and chronic diseases. Alpha-tocopherol and selenium were not significantly associated with ox-LDL/LDL-cholesterol ratio.Conclusions-Older women who are overweight or obese or who have low total serum carotenoids are more likely to have higher lipoprotein oxidation. Weight reduction in overweight/obese women and increased intake of carotenoid-rich foods may potentially reduce lipoprotein oxidation. Keywordsbody mass index; carotenoids; low-density lipoproteins; obesity; oxidative stress Oxidation of low-density lipoproteins is considered a key factor in the pathogenesis of atherosclerosis and cardiovascular disease [1]. Oxidized low-density lipoproteins (ox-LDL) are taken up by scavenger receptors on macrophages and contribute to the formation of foam cells and atherosclerotic lesions [1]. Elevated circulating ox-LDL are associated with more severe atherosclerotic lesions [2], and high circulating levels of ox-LDL have been shown to be independently predictive of subclinical atherosclerosis [3] and acute coronary heart disease [4].Obesity is a strong risk factor for cardiovascular disease [5]. Both abdominal obesity and general obesity (body mass index >30 kg/m 2 ) were shown to be independently associated with circulating ox-LDL among men and women, aged in Spain [6]. Among subjects with LDL is a large particle that contains one apoB molecule and a large number of triacylglycerol, free cholesterol, cholesterol ester, and phospholipid molecules [9]. LDL contains carotenes and xanthophylls, the two major classes of carotenoids in humans, and carotenoids protect LDL against oxidation [10]. The carotenoid content of LDL has been shown to be strongly correlated with serum carotenoid concentrations [11,12].Although carotenoids are known to protect LDL particles from oxidation, the relationship between total serum carotenoid concentrations and circulating ox-LDL has not been well characterized in humans. We hypothesized that both obesity and low total serum carotenoids were associated with elevated circulating ox-LDL in older adults. To address this hypothesis, we assessed serum ox-LDL among older women living in the community who participated in the Women's Health and Aging Study I. Subjects and MethodsSubjects in this study were women, aged 65 and older, who participated in the Women's Health and...

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Section: Discussionmentioning

confidence: 75%

Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

et al. 2008

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“…We also found increased levels of TBARS among patients with NAFLD. High OS has been described previously to be associated with obesity [28,29]. Also, there is accumulating evidence that mitochondrial dysfunction (more particularly respiratory chain defects) plays an important role in the pathophysiology of advanced forms of NAFLD, whatever its initial cause [29,30].…”

Section: Discussionmentioning

confidence: 86%

“…High OS has been described previously to be associated with obesity [28,29]. Also, there is accumulating evidence that mitochondrial dysfunction (more particularly respiratory chain defects) plays an important role in the pathophysiology of advanced forms of NAFLD, whatever its initial cause [29,30]. Mitochondrial beta-oxidation of fatty acids can be increased, such as in insulin resistance-associated NAFLD, or decreased, as in drug-induced NAFLD [31,32].…”

Section: Discussionmentioning

confidence: 96%

Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease

et al. 2008

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Purpose Altered redox status has been implicated in pathogenesis of alcoholic liver disease (ALD) as well as in nonalcoholic fatty liver disease (NAFLD). This study was planned to find the relative role of redox status in these two diseases. Methods A total of 44 patients with ALD and 32 patients with NAFLD and 25 apparently healthy controls were included in the study. Redox status was estimated by measuring oxidative stress (superoxide dismutase (SOD) and lipid peroxidation products as thiobarbituric acid reactive substances (TBARS)) and antioxidant status (ferric reducing ability of plasma (FRAP) and vitamin C). Results TBARS level was raised significantly in both ALD (3.5 (2.3-9.4) vs. 1.8 (0.5-4.1) nmol/ml; P = 0.0001) and NAFLD (5.1 (1-10.2) vs. 1.82 (0.51-4.1) nmol/ml; P = 0.0001) as compared with controls, but was not different between ALD and NAFLD. SOD was significantly higher in ALD as compared to NAFLD (2.4 (1.3-7.8) vs. 0.68 (0.05-19.1) U/ml; P = 0.0001) and controls (1.12 (0.01-3.5) U/ml; P = 0.001). FRAP was lower in ALD as compared with 3) lmol of Fe +2 liberated; P = 0.001) but similar to that of controls (340.9 (141.5-697.5) lmol of Fe +2 liberated). Conclusions ALD patients have a higher degree of redox imbalance as compared with NAFLD patients

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“…Circulating levels of adhesion molecules, such as ICAM-1, VCAM-1, and E-selectin, are elevated in subjects with metabolic syndrome and type 2 diabetes and are positively correlated with CVD [29]. Oxidative stress and injuries to the vessel wall attract inflammatory cells, and then these inflammatory cells induce the expression of adhesion molecules, resulting in further inflammatory processes [30].…”

Section: Discussionmentioning

confidence: 99%

Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients

et al. 2011

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Circulating Levels of Oxidative Stress Markers and Endothelial Adhesion Molecules in Men with Abdominal Obesity

Cited by 173 publications

References 42 publications

Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

Circulating oxidized low-density lipoproteins are associated with overweight, obesity, and low serum carotenoids in older community-dwelling women

Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease

Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients

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