Circulating levels of metals are related to carotid atherosclerosis in elderly

Lind, P. Monica; Olsén, Lena; Lind, Lars

doi:10.1016/j.scitotenv.2011.11.064

Cited by 49 publications

(44 citation statements)

References 71 publications

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“…The hallmark of ischemia heart disease is atherosclerosis. The major underlying pathology in atherosclerosis is the slow development and subsequent rupture of thrombogenic lipidladen plaques in the blood vessels leading to tissue hypoxia and necrosis that shows as heart attack [3,4]. Studies on the roles of trace elements in health and disease over the past 50 years have led to a good understanding of their mode of actions and their essentiality to life [5].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Elemental Concentrations in the Scalp Hair and Nails of Myocardial Infarction Patients Versus Controls from Pakistan

Ilyas

Ahmad

Shah

2015

Biol Trace Elem Res

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Ischemia heart disease has become a ubiquitous cause of morbidity and a leading contributor to mortality worldwide. The present study was aimed to quantify the elemental levels for Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Pb, Sr, and Zn in the scalp hair and nails of myocardial infarction (MI) patients and counterpart controls by flame atomic absorption spectrophotometry. The effects of elemental imbalances on the development of atherosclerosis were evaluated. Average concentrations of Pb (14.7 μg/g), Sr (21.6 μg/g), and Cr (3.70 μg/g) were significantly higher in the scalp hair of the patients, while those of Na, K, Mg, Fe, Mn, and Cd were measured at almost comparable levels in the scalp hair of the patients and controls. In the case of nail samples, average concentrations of Na (1260 μg/g), K (873 μg/g), Sr (70.9 μg/g), Cu (16.6 μg/g), and Mn (16.9 μg/g) were significantly higher in the patients than controls. The correlation study revealed significantly divergent mutual variations among the elements in MI patients and controls. Principal component analysis also manifested the diverse apportionment of the elements in both donor groups. Most of the elements revealed significant disparities in their concentrations based on gender, abode, and smoking habits of the donors in both groups. In conclusion, the elemental imbalance has potential proatherogenic effect that would have a significant impact on sensitive population groups.

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Section: Introductionmentioning

confidence: 99%

Comparative Study of Elemental Concentrations in the Scalp Hair and Nails of Myocardial Infarction Patients Versus Controls from Pakistan

Ilyas

Ahmad

Shah

2015

Biol Trace Elem Res

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“…The data obtained from these groups were compared to control subjects without significant atherosclerotic changes in carotid artery. Previous studies have reported that advanced atherosclerotic lesions have higher metal ion levels than initial lesions or healthy tissue (11,21,22).…”

Section: Discussionmentioning

confidence: 92%

“…Thus, data on the abundance of metal ions in atherosclerotic lesions, and its potential correlation with clinical symptoms is lacking. A number of studies have reported associations between metals and atherosclerosis, evaluated by carotid artery intima-media thickness (IMT) measurement (11).…”

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confidence: 99%

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Tasić¹,

Tasić²,

Veselinović³

et al. 2015

Acta Physiologica Hungarica

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The aim of this study was to investigate the iron concentrations in serum and carotid plaque in patients with different morphology of carotid atherosclerotic plaque and compared with other metal ions. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients. Control group consisted of 27 patients, without carotid atherosclerosis. Atherosclerotic plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Iron, copper and zinc concentration in plaque, carotid artery and serum were measured by spectrophotometry. Serum iron concentrations were higher in patients with hemorrhagic plaques in comparison to the control group (4.7 μmol/l ± 1.2 vs. 2.1 μmol/l ± 0.8, p < 0.05). Iron concentrations were higher in patients with hemorrhagic plaques in comparison to fibrolipid plaques (72.1 ± 14.3 μg/g vs. 39.3 ± 22.9 μg/g; p < 0.05). Negative significant correlation was found for zinc in serum and plaque iron concentration in patients (p < 0.05). We also demonstrated positive significant correlation for copper and iron in serum (p < 0.05). The data obtained in the current study are consistent with the hypothesis that high iron levels may contribute to atherosclerosis and its complications as factors in a multifactorial disease.Keywords: carotid plaque, atherosclerosis, iron, zinc, copperOver the last 30 years, several studies in animals and humans assessed the effect of increased body iron levels on atherosclerosis, yielding conflicting results.Iron is a key element in many biochemical processes and shortage of iron causes damage to cells and organs. On the other hand, excess iron could be harmful because it is able to catalyse the formation of highly reactive oxygen and hydrogen radicals when present in the unbound state. Transition metal ions, established catalysts of protein, lipid and DNA oxidation, are present at elevated levels in human atherosclerotic plaques, and in some animal models, consistent with the hypothesis that metal ions contribute to both plaque formation and its destabilization (19,21,23), though the role of metal ions remains controversial (16,29).Epidemiological studies have reported an increased incidence of cardiovascular disease (CVD) in subjects with overt iron overload (7,8,19). Recent studies on cardiovascular evaluation and outcome in high-versus low-frequency blood donors have demonstrated improvements in surrogate markers of vascular health such as decreased oxidative stress, and

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“…Much of this evidence is summarised in two position statements released by the Endocrine Society on the role of environmental endocrine-disrupting chemicals in population health and disease 10 11. Epidemiological studies from urban areas have shown an association of metals such as cadmium, arsenic, lead, mercury and uranium with T2D12 13 and CVDs 14. These toxic metals are ubiquitous environmental contaminants and have been implicated in abnormal glucose metabolism, beta cell dysfunction and atherosclerosis 12–15…”

Section: Introductionmentioning

confidence: 99%

Metals in urine in relation to the prevalence of pre-diabetes, diabetes and atherosclerosis in rural India

Velmurugan

Swaminathan²,

Veerasekar

et al. 2018

Occup Environ Med

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Circulating levels of metals are related to carotid atherosclerosis in elderly

Cited by 49 publications

References 71 publications

Comparative Study of Elemental Concentrations in the Scalp Hair and Nails of Myocardial Infarction Patients Versus Controls from Pakistan

Comparative Study of Elemental Concentrations in the Scalp Hair and Nails of Myocardial Infarction Patients Versus Controls from Pakistan

Iron concentrations in atherosclerotic plaque and serum in patients with carotid atherosclerosis

Metals in urine in relation to the prevalence of pre-diabetes, diabetes and atherosclerosis in rural India

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