Circulating levels of MCP‐1 are increased in women with gestational diabetes

Klein, Katharina; Satler, Miriam; Elhenicky, Marie; Brix, Johanna; Krzyżanowska, Katarzyna; Schernthaner, Guntram; Husslein, Peter; Schernthaner, Gerit-Holger

doi:10.1002/pd.2064

Cited by 33 publications

(31 citation statements)

References 22 publications

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“…Clinically, results from previous studies have also indicated that MCP1 is elevated during pregnancy and further augmented in GDM compared with NTG. Consistent with the results reported by Klein et al (2008), our clinical detection of MCP1 also found elevated MCP1 concentration in GDM women; moreover, elevated MCP1 is associated with abnormal glucose tolerance. Although it has been proposed that this inflammation is mediated by the placenta (Klein et al 2008), our results confirmed that elevated MCP1 levels in pregnancy were produced by increased fat mass under surged CG stimulation.…”

Section: Discussionsupporting

confidence: 81%

“…Moreover, prepregnancy BMI in GDM subjects was higher than that of NGT subjects (25.83G2.7 versus 23.85G2.62), and prepregnancy BMI was associated with fasting (P!0.0001) and 1-h (PZ0.002) glucose levels ( Table 3). Results of ELISA assays also indicated that MCP1, a key factor in the recruitment and activation of peripheral blood leukocytes, was elevated in GDM woman compared with healthy pregnant women (83.71G21.1 versus 100.72G32.82 pg/ml), which was consistent with previous report (Klein et al 2008). Furthermore, MCP1 levels were associated with abnormal 1-(PZ0.025) and 2-h (PZ0.008) post glucose load (Table 3).…”

Section: Cg Modulates Proinflammatory Cytokines In 3t3-l1 Adipocytessupporting

confidence: 80%

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High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes

Fan

Wang

et al. 2015

Journal of Molecular Endocrinology

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Gestational diabetes mellitus (GDM) presents with moderate inflammation, insulin resistance and impaired glucose uptake, which may result from increased maternal fat mass and increased circulation of placental hormones and adipokines. In this study, we set out to test whether the surge in chorionic gonadotrophin (CG) secretion is a cause of inflammation and impaired insulin sensitivity in GDM. We first found that LH/chorionic gonadotrophin receptors (CG/LHR) were expressed at low levels in insulin-sensitive murine 3T3-L1 adipocytes and murine C2C12 myocytes. CG treatment not only directly reduced insulin-responsive gene expression, including that of glucose transporter 4 (GLUT4), but also impaired insulin-stimulated glucose uptake in 3T3-L1 cells. Moreover, CG treatment increased the expression of the proinflammatory cytokine monocyte chemotactic protein 1 (MCP1) and upregulated nuclear factor k-light-chain-enhancer of activated B cells (NF-kB) activity in 3T3-L1 cells. Clinically, pregnant women who had higher CG levels and elevated MCP1 developed GDM. Above all, apart from prepregnancy BMI and MCP1 level, CG level was associated with abnormal glucose tolerance. In summary, our findings confirmed that higher CG levels in pregnancy possibly played a role in GDM development partly by impairing the functions of insulin, such those involved in as glucose uptake, while promoting inflammation in adipocyte.

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Section: Discussionsupporting

confidence: 81%

Section: Cg Modulates Proinflammatory Cytokines In 3t3-l1 Adipocytessupporting

confidence: 80%

High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes

Fan

Wang

et al. 2015

Journal of Molecular Endocrinology

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“…TNFa, which is a significant predictor of insulin resistance during pregnancy [38], is higher in pregnant women with GDM when compared to NGT women [36,37]. Similarly, other circulating proinflammatory cytokines like MCP-1 [35], IL-1b [40] and IL-6 [31,41,59] are also positively correlated with GDM. Therefore, it is possible, that maternal systemic inflammation associated with GDM may induce the expression of placental Nurr1 and Nur77.…”

Section: Discussionmentioning

confidence: 85%

“…An overproduction of placental TNF-a have been demonstrated in patients with GDM [39] and is associated with increased fetal adiposity [29]. Other circulating pro-inflammatory cytokines like monocyte chemoattractant protein-1 (MCP-1) [35], IL-1b [40] and IL-6 [41] are also positively correlated with GDM. Notably, the upstream factors involved in the regulation of these pro-inflammatory cytokines in human placenta are not known.…”

Section: Introductionmentioning

confidence: 97%

The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes

Lappas

2014

Placenta

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“…Low-grade maternal inflammation is a key feature of pregnancies complicated by GDM [33–39]. There is extensive evidence that show human placenta and adipose tissue are important sites involved in the propagation of this maternal inflammation [15, 21, 22, 30, 32, 40–48].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle

et al. 2017

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Gestational diabetes mellitus (GDM), which complicates up to 20% of all pregnancies, is associated with low-grade maternal inflammation and peripheral insulin resistance. Sterile inflammation and infection are key mediators of this inflammation and peripheral insulin resistance. Resveratrol, a stilbene-type phytophenol, has been implicated to exert beneficial properties including potent anti-inflammatory and antidiabetic effects in non-pregnant humans and experimental animal models of GDM. However, studies showing the effects of resveratrol on inflammation and insulin resistance associated with GDM in human tissues have been limited. In this study, human placenta, adipose (omental and subcutaneous) tissue and skeletal muscle were stimulated with pro-inflammatory cytokines TNF-α and IL-1β, the bacterial product lipopolysaccharide (LPS) and the synthetic viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) to induce a GDM-like model. Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1α, IL-1β and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue. Resveratrol also significantly restored the defects in the insulin signalling pathway and glucose uptake induced by TNF-α, LPS and poly(I:C). Collectively, these findings suggest that resveratrol reduces inflammation and insulin resistance induced by chemical and microbial products. Resveratrol may be a useful preventative therapeutic for pregnancies complicated by inflammation and insulin resistance, like GDM.

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Circulating levels of MCP‐1 are increased in women with gestational diabetes

Abstract: The elevation of MCP-1 in the third trimester in gestational diabetes mellitus suggests an association between inflammation and GDM.

Cited by 33 publications

References 22 publications

High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes

High levels of chorionic gonadotrophin attenuate insulin sensitivity and promote inflammation in adipocytes

The NR4A receptors Nurr1 and Nur77 are increased in human placenta from women with gestational diabetes

Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle

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