Circulating Levels of LAMP2 in Coronary Artery Disease: Association with Serum Lipid Profile

Teimouri, Maryam; Shabani, Parisa; Zali, Fatemeh; Najafi, Moslem; Shateri, Hossein; Asadnia, Mostafa; Vatannejad, Akram; Doosti, Mahmood

doi:10.1055/s-0042-119649

Cited by 3 publications

(3 citation statements)

References 25 publications

(36 reference statements)

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“…Patients with coronary artery disease showed an upregulation of LAMP2 expression in peripheral blood mononuclear cells when compared with the control group. The collected data revealed a role for LAMP2 in lipid homeostasis and coronary artery disease development [57]. Atherosclerosis progression is accelerated in NEIL3-deficient individuals via activation of the Akt signaling pathway and other non-canonical processes impacting the phenotype of vascular smooth muscle cells [58].…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans

Öztan,

Bozbuğa,

İşsever

et al. 2023

Genes

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Background: Thromboangiitis obliterans (TAO) causes vascular insufficiency due to chronic inflammation and abrupt thrombosis of the medium and small arteries of the extremities. In our study, we aimed to determine biomarkers for the diagnosis of TAO by evaluating 15 male TAO patients with Shinoya diagnostic criteria and 5 healthy controls who did not have TAO-related symptoms in their family histories. Methods: The Clariom D Affymetrix platform was used to conduct microarray analysis on total RNA extracted from whole blood. A total of 477 genes (FC ≤ 5 or >5) common to the fifteen patient and five control samples were selected using comparative microarray analysis; among them, 79 genes were upregulated and 398 genes were downregulated. Results: According to FC ≤ 10 or >10, in the same TAO patient and control group, 13 genes out of 28 were upregulated, whereas 15 genes were downregulated. The 11 key genes identified according to their mean log2FC values were PLP2, RPL27A, CCL4, FMNL1, EGR1, EIF4A1, RPL9, LAMP2, RNF149, EIF4G2, and DGKZ. The genes were ranked according to their relative expression as follows: FMNL1 > RNF149 > RPL27A > EIF4G2 > EIF4A1 > LAMP2 > EGR1 > PLP2 > DGKZ > RPL9 > CCL4. Using protein–protein interaction network analysis, RPL9, RPL27A, and RPL32 were found to be closely related to EIF4G2 and EIF4A1. The Reactome pathway found pathways linked to 28 genes. These pathways included the immune system, cellular responses to stress, cytokine signaling in the immune system, and signaling by ROBO receptors. Conclusions: By figuring out the protein expression levels of the genes that have been found to explain how TAO disease works at the molecular level, it will be possible to figure out how well these chosen transcripts can diagnose and predict the disease.

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans

Öztan,

Bozbuğa,

İşsever

et al. 2023

Genes

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“…There is almost no change in glucose metabolism under normal dietary feeding, but LAMP2 KO mice show poor resistance to obesity caused by a HFD, high insulin hyperglycemia and tissue lipid accumulation, accompanied by higher energy expenditure 72 . In coronary atherosclerosis disease, it has been found that the serum concentration of LAMP2 is positively correlated with LDL‐C, and the increased level of LAMP2 in the tissues (which may be reflected by the increased release of LAMP2 in the serum) may cause LDL‐C uptake, factors which reduce and increase serum LDL‐C levels 72,73 …”

Section: Lmps and Lipid Metabolismmentioning

confidence: 99%

“…72 In coronary atherosclerosis disease, it has been found that the serum concentration of LAMP2 is positively correlated with LDL-C, and the increased level of LAMP2 in the tissues (which may be reflected by the increased release of LAMP2 in the serum) may cause LDL-C uptake, factors which reduce and increase serum LDL-C levels. 72,73…”

Section: Lmps and Abnormalities Of Lipid Regulationmentioning

confidence: 99%

The role of lysosomal membrane proteins in glucose and lipid metabolism

Geng

et al. 2021

The FASEB Journal

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Lysosomes have long been regarded as the "garbage dump" of the cell. More recently, however, researchers have revealed novel roles for lysosomal membranes in autophagy, ion transport, nutrition sensing, and membrane fusion and repair.With active research into lysosomal membrane proteins (LMP), increasing evidence has become available showing that LMPs are inextricably linked to glucose and lipid metabolism, and this relationship represents mutual influence and regulation. In this review, we summarize the roles of LMPs in relation to glucose and lipid metabolism, and describe their roles in glucose transport, glycolysis, cholesterol transport, and lipophagy. The role of transport proteins can be traced back to the original discoveries of GLUT8, NPC1, and NPC2, which were all found to have significant roles in the pathways involved in glucose and lipid metabolism. CLC-5 and SIDT2-knockout animals show serious phenotypic disorders of metabolism, and V-ATPase and LAMP-2 have been found to interact with proteins related to glucose and lipid metabolism. These findings all emphasize the critical role of LMPs in glycolipid metabolism and help to strengthen How to cite this article:

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Circulating low density lipoprotein (LDL)

Khosravi

Hosseini‐Fard

Najafi

2018

Hormone Molecular Biology and Clinical Investigation

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Low-density lipoprotein (LDL) particles are known as atherogenic agents in coronary artery diseases. They modify to other electronegative forms and may be the subject for improvement of inflammatory events in vessel subendothelial spaces. The circulating LDL value is associated with the plasma PCSK-9 level. They internalize into macrophages using the lysosomal receptor-mediated pathways. LDL uptake is related to the membrane scavenger receptors, modifications of lipid and protein components of LDL particles, vesicular maturation and lipid stores of cells. Furthermore, LDL vesicular trafficking is involved with the function of some proteins such as Rab and Lamp families. These proteins also help in the transportation of free cholesterol from lysosome into the cytosol. The aggregation of lipids in the cytosol is a starting point for the formation of foam cells so that they may participate in the primary core of atherosclerosis plaques. The effects of macrophage subclasses are different in the formation and remodeling of plaques. This review is focused on the cellular and molecular events involved in cholesterol homeostasis.

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Circulating Levels of LAMP2 in Coronary Artery Disease: Association with Serum Lipid Profile

Cited by 3 publications

References 25 publications

Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans

Comparative Analysis of Transcriptome Profiles in Patients with Thromboangiitis Obliterans

The role of lysosomal membrane proteins in glucose and lipid metabolism

Circulating low density lipoprotein (LDL)

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