Circulating levels of IL-18 in adult and paediatric patients with HIV-1 infection

Torre, Donato; Speranza, Filippo; Martegani, Roberto; Pugliese, A.; Castelli, Francesco; Basilico, Cristina; Biondi, Gilberto

doi:10.1097/00002030-200009290-00023

Cited by 35 publications

(29 citation statements)

References 9 publications

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“…The serum concentrations, however, did not show significant (P Ͼ 0.05) correlation with CD4 ϩ T-cell counts, CD8 ϩ T-cell counts, ratios between these two cell counts, or the viral loads in plasma of the patients. These results are in agreement with those of an earlier report of elevated IL-18 levels in the sera of AIDS patients (42). We do not know if HIV-1 or any of its gene products plays a direct role in the enhanced concentration of this cytokine in the sera of HIV-infected individuals.…”

Section: Discussionsupporting

confidence: 91%

Elevated Levels of Circulating Interleukin-18 in Human Immunodeficiency Virus-Infected Individuals: Role of Peripheral Blood Mononuclear Cells and Implications for AIDS Pathogenesis

Ahmad

Sindhu

Toma

et al. 2002

J Virol

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Section: Discussionsupporting

confidence: 91%

Elevated Levels of Circulating Interleukin-18 in Human Immunodeficiency Virus-Infected Individuals: Role of Peripheral Blood Mononuclear Cells and Implications for AIDS Pathogenesis

Ahmad

Sindhu

Toma

et al. 2002

J Virol

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“…IL-18 enhances IFN-γ production in the presence of IL-12 [34] and has been implicated in increased antiviral activity in some animal models [35] [36]. However, an elevated level of IL-18 has been noted in chronic HIV-1 infection as proviral cytokine which may disrupt the expression of NK receptors and induce apoptosis [37] [38]. Under normal signal transduction, these cytokines act synergistically with IFN-α/β to enhance the development and activation of both NK and T cells [5] [42].…”

Section: Discussionmentioning

confidence: 99%

Higher Type 1 Interferon Levels in Plasma of Asymptomatic HIV-2 than in HIV-1 Individuals

Nuvor

Whittle

Rowland‐Jones

et al. 2016

AID

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A number of cytokines are secreted during HIV infection that enhances both innate and adaptive immune responses. Interferon-α/β/γ, IL-12, IL-15 and IL-18 have been found to contribute to the development, maturation, differentiation and function of NK and other immune cells. The levels of IFN-α/β/γ, IL-12, IL-15 and IL-18 were compared in the plasma of 90 HIV-1 infected and 90 HIV-2 infected subjects by ELISA or Cytometric Beads Array assays. The HIV-infected subjects were stratified according to CD4 + T cell counts into three groups: >500, 200 -500 and <200 cells/ul, with 30 subjects in each group. Cytokine levels were also determined in the plasma of 50 HIV uninfected blood bank donors. Among the cytokines tested, IFN-α was found to be significantly increased in HIV-2 infected compared to HIV-1 infected subjects at high CD4 + T cell counts (p = 0.001). The levels of IFN-β were seen to differ between the two infections in patients from the category of medium CD4 + T cell counts: this was significantly increased in HIV-2 infected patients (p < 0.001) as well as compared to uninfected controls (p = 0.001). The levels of IFN-γ were similar at all the CD4 + T cell categories except for an increase in HIV-2 infected patients at low CD4 + T cell counts (p = 0.02). The levels of these cytokines were similar in all HIV-1 subjects. Also, the level of IL-12p70 was similar between the two infections but significantly higher in HIV-2 at low compared to medium CD4 + T cells categories (p = 0.047). Similar to IFN-γ and IL-12p70, the levels of both IL-18 and IL-15 were found to be significantly higher in HIV-2 infected patients compared to HIV-1 at low CD4 + T cell counts (p < 0.05). These data show that there is variability in the levels of innate cytokines at different stages of HIV infection but the finding of increased IFN-α in HIV-2 infected S. V. Nuvor et al. 16asymptomatic subjects is consistent with the high innate NK responses previously noted at this stage of infection.

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“…These cytokine disturbances play an important role in the immunopathogenesis of AIDS in HIV-infected persons. Concerning IL-18, we and others have demonstrated increased concentrations of this cytokine in HIV-infected persons (3,30,33; see reference 32 for a review). The simian immunodeficiency virus (SIV), which is a close cousin of HIV-1, also induces IL-18 production in rhesus monkeys (12).…”

mentioning

confidence: 88%

Potential Role of Interleukin-18 in the Immunopathogenesis of AIDS: Involvement in Fratricidal Killing of NK Cells

Iannello

Samarani

Débbeche

et al. 2009

J Virol

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Circulating levels of IL-18 in adult and paediatric patients with HIV-1 infection

Cited by 35 publications

References 9 publications

Elevated Levels of Circulating Interleukin-18 in Human Immunodeficiency Virus-Infected Individuals: Role of Peripheral Blood Mononuclear Cells and Implications for AIDS Pathogenesis

Elevated Levels of Circulating Interleukin-18 in Human Immunodeficiency Virus-Infected Individuals: Role of Peripheral Blood Mononuclear Cells and Implications for AIDS Pathogenesis

Higher Type 1 Interferon Levels in Plasma of Asymptomatic HIV-2 than in HIV-1 Individuals

Potential Role of Interleukin-18 in the Immunopathogenesis of AIDS: Involvement in Fratricidal Killing of NK Cells

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