Circulating Levels of Hypoxia-regulating MicroRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia

Metabolite and protein shifts in mature erythrocyte under hypoxia

“…Comparing plasma exosomal miRNAs in HAPC patients with healthy controls, miR-122-5p, miR-4235p, miR-4433b-3p, miR-1291, miR-106b-5p, and miR-200c-3p were aberrantly expressed in HAPC patients. 101 Among them, miR-122-5p was the best predictor of HAPC, directly targeting HIF-1A . 124 These studies provide background on exosomal miRNAs for future HAPC research.…”

“…Many studies have reported that miRNAs are affected by hypoxia, 96 , 100 , 101 , 102 and these miRNAs are termed hypoxia-regulated miRNAs (HRMs). Among the HRMs, miR-210 has been extensively studied, implicated in various biological processes throughout human tissues and organs.…”