Circulating levels of fibroblast growth factor 21 in early-stage diabetic kidney disease

Esteghamati, Alireza; Khandan, Amirhossein; Momeni, Alireza; Behdadnia, Aram; Ghajar, Alireza; Nikdad, Mohammadsadegh; Noshad, Sina; Nakhjavani, Manouchehr; Afarideh, Mohsen

doi:10.1007/s11845-017-1554-7

Cited by 27 publications

(17 citation statements)

References 30 publications

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“…The mechanism underlying the link between the FGF21 gene region and eGFR is still unknown and should be further investigated by functional studies. Evidences also showed the independent association of FGF21 levels with urinary albumin excretion (UAE) or albuminuria in type 2 diabetic patients [15, 16]. However, no evidence of association with AER was found for variants in the FGF21 gene region in our study.…”

Section: Discussioncontrasting

confidence: 57%

Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Wang

Zhu

Chen

et al. 2019

Journal of Diabetes Research

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Aims. Fibroblast growth factor 21 (FGF21) is closely linked with metabolic disorders including diabetes. Evidences suggested that FGF21 may play a protective role against diabetic kidney disease (DKD). However, the relationship between genetic variants in the FGF21 gene region and DKD remains unknown. In our study, we aimed to investigate the association of genetic variations in this gene region with DKD and DKD-related clinical traits. Materials and Methods. We recruited 1340 Han Chinese participants with type 2 diabetes, including 596 DKD patients and 744 patients who was diagnosed with diabetes for more than 5 years but did not progress to DKD. Three single-nucleotide polymorphisms were selected (rs2071699, rs838136, and rs499765) and genotyped. The association between these SNPs and DKD as well as DKD-related quantitative traits was analyzed. Results. We did not find any significant association between these SNPs and susceptibility to DKD in the present study. However, a significant association with estimated glomerular filtration rate (eGFR) was detected: in the non-DKD group, rs838136 was significantly associated with eGFR under an additive model (β=0.013±0.006, P=0.0295, β was calculated for log10eGFR) as well as a recessive model (P=0.0385) and rs499765 was associated with eGFR under a dominant model (P=0.0411) and in the DKD group, rs499765 showed a trend toward association with eGFR under an additive model (β=−0.022±0.012, P=0.0820, β was calculated for log10eGFR) and showed a significant association with eGFR under a dominant model (P=0.0182). Conclusions. Our findings indicated that genetic variations adjacent to FGF21 were associated with eGFR in Chinese diabetic patients.

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Section: Discussioncontrasting

confidence: 57%

Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Wang

Zhu

Chen

et al. 2019

Journal of Diabetes Research

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“…Serum FGF21 levels progressively increase in parallel with the progression from normal to microalbuminuria and from micro to overt albuminuria, even before an impairment of renal function becomes apparent. It appears that serum FGF21 level is strongly associated with the onset of nephropathy in T2D patients and is an independent predictor of loss of renal function in these patients [4–6]. …”

Section: Fgf21 and Diabetic Nephropathymentioning

confidence: 99%

“…There is a positive correlation of FGF21 level with mortality in dialysis patients [3]. In type 2 diabetic (T2D) patients, serum FGF21 levels correlate with nephropathy onset, albuminuria, and risk of progression to end-stage renal disease (ESRD) [4–6]. In contrast, in experimental in vitro and in vivo models, FGF21 has been proposed to exert protective effects against glucotoxicity and lipotoxicity, and to reduce inflammation, oxidative stress and fibrosis [7–9].…”

Section: Introductionmentioning

confidence: 99%

Fibroblast growth factor 21 in chronic kidney disease

et al. 2018

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Fibroblast growth factor 21 (FGF21) is a member of the endocrine FGF family that acts as a metabolic regulator of both glucose and lipid metabolism. Similar to fibroblast growth factor 23 (FGF23), serum FGF21 levels rise progressively with the loss of renal function, reaching 20 times normal values in end-stage renal disease. In patients with chronic kidney disease (CKD), higher serum FGF21 levels correlate with poorer metabolic profile, higher inflammatory markers, more comorbidities, and higher mortality. The high serum FGF21 levels are above and beyond what can be explained by the loss of FGF21 renal clearance, suggesting increased production and/or impaired non-renal clearance. In diabetic nephropathy, serum FGF21 levels correlate with the severity of albuminuria and faster loss of glomerular filtrate rate and can potentially be a biomarker of poor prognostic. The observational and associative human data contrast sharply with in vitro and in vivo preclinical experimental data, which is more in line with a protective role of FGF21 in chronic nephropathies. We here review the physiology of FGF21, and the literature regarding its behavior in CKD with particular focus on diabetic nephropathy. Finally, we speculate on the role of FGF21 in CKD.

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“…on characteristic parameters related to energy metabolism in dairy cows 1) lism, and energy balance (1,2). Recent studies show that systemic administration of recombinant FGF-21 to cultured cells (5), rodents (4), and primates (3,10) improves glucose and lipid metabolism, suggesting that FGF-21 might be an interesting candidate for treating diabetes and other metabolic dysregulations clustered in animals with a metabolic syndrome (6). However, FGF-21 has obvious species specificity, and research on FGF-21 in dairy cows is limited compared with that in humans and other mammals.…”

Section: Effects Of Exogenous Fibroblast Growth Factor-21mentioning

confidence: 99%

Effects of exogenous Fibroblast Growth Factor-21 on characteristic parameters related to energy metabolism in dairy cows

Chen¹,

Wu²,

Gao³

et al. 2019

Medycyna Weterynaryjna

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Negative energy balance (NEB) is a common pathological foundation of fatty liver and ketosis. Liver and fat tissue are the major organs of lipid metabolism, which is also a key metabolic pathway that regulates NEB development during the perinatal period. Fibroblast growth factor-21 (FGF-21) is a protein hormone that plays an important role in adipose lipid metabolism and liver gluconeogenesis. Our aim was to investigate the effects of exogenous FGF-21 on characteristic parameters related to energy balance in dairy cows. Ten non-pregnant, non-lactating Holstein-Friesian dairy cows were randomly allocated into two groups. The interventions were exogenous FGF-21 injection group received 1 ug/kg BW (body weight) of recombinant bovine FGF-21 by intravenous injection, and control group received physiological saline injections by intravenous injection. In comparison to saline injections, intravenous injections of FGF-21 either increased or tended to increase concentrations of FGF-21 (p < 0.05), BHBA (p < 0.05), adiponectin, leptin and HDL-C. FGF-21 injections decreased or tended to decrease concentrations of insulin, glucose, glucagon (p < 0.05), ALT/GPT (p < 0.05), AST/GOT (p < 0.05), urate, creatinine (p < 0.05), BUN, triglyceride (p < 0.05), T-CHO and LDL-C (p < 0.05). The results indicate that FGF-21 has only negative effects on the metabolites and metabolic hormones related to NEB in serum of dairy cows, but it has more beneficial effects on prominent adipokines, liver function index, renal function index, lipoprotein profiles related to the pathological changes that occurred in NEB.

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Circulating levels of fibroblast growth factor 21 in early-stage diabetic kidney disease

Cited by 27 publications

References 30 publications

Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes

Fibroblast growth factor 21 in chronic kidney disease

Effects of exogenous Fibroblast Growth Factor-21 on characteristic parameters related to energy metabolism in dairy cows

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