Circulating levels of environmental contaminants are associated with dietary patterns in older adults

Ax, Erika; Lampa, Erik; Lind, Lars; Salihović, Samira; Bavel, Bert van; Cederholm, Tommy; Sjögren, Per; Lind, P. Monica

doi:10.1016/j.envint.2014.11.008

Cited by 21 publications

(9 citation statements)

References 45 publications

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“…In the present study, however, there was no association of the “healthy” diet pattern (which is analogous to the “WHO-recommended” and “balanced” patterns in previous studies) with B-Pb in the complete case analysis (and indeed it was predictive of B-Pb ≥5 µg/dL in the imputed dataset). Comparisons of associations of dietary patterns in pregnancy with B-Pb with those from nonpregnant and older adults in previous studies (18–20) may have limited validity: lead absorption, mobilization, and excretion likely differ with physiologic status.…”

Section: Discussionmentioning

confidence: 92%

“…A “prudent” dietary pattern (characterized by higher intakes of fruit, legumes, vegetables, whole grains, poultry, and seafood) was not associated with bone or blood lead (20). In older Swedish men and women, a “low-carbohydrate/high-protein” pattern (characterized by high intakes of dairy products, meat and meat products, and fish) was positively associated with B-Pb, and a “WHO-recommended” pattern [characterized by high fruit and vegetable, low sugar and salt, and low fat, particularly saturated fat, intake (38)] was negatively related to B-Pb (18). In Korean adults, a “balanced diet” pattern (characterized by high intakes of vegetables, fish, meat, and milk) was negatively associated with B-Pb, whereas an “alcohol and noodle” pattern (characterized by high intakes of alcohol and noodles, and a lack of fruits, whole-grain products, milk, and dairy products) was positively associated with B-Pb.…”

Section: Discussionmentioning

confidence: 99%

“…Principal components analysis (PCA), in which underlying dimensions in the data are identified based on inter-item correlations, is the most frequently used method for examining dietary patterns (17). Dietary patterns identified via PCA were predictive of bone and B-Pb in elderly men in the United States and Sweden, and in Korean adolescents and adults (18–20). To our knowledge, dietary pattern analysis has not been undertaken for pregnant women in association with biomarkers of lead exposure: this is important because the fetus is vulnerable to the effects of lead due to the rapid development of the nervous system (21, 22).…”

Section: Introductionmentioning

confidence: 99%

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Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Taylor

Doerner

Northstone

et al. 2019

The Journal of Nutrition

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Background During pregnancy lead crosses the placenta freely and can have adverse effects on the fetus, with the potential for lifelong impact on the child. Identification of dietary patterns and food groups in relation to measures of lead status could provide a more useful alternative to nutrient-specific advice to minimize fetal lead exposure. Objectives The aim of this study was to evaluate whether dietary patterns and food groups are associated with blood lead concentration (B-Pb) in pregnancy. Design Whole blood samples were collected at a median of 11 wk gestation (IQR 9–13 wk) from women enrolled in the Avon Longitudinal Study of Parents and Children birth cohort study, and analyzed for lead. Dietary pattern scores were derived from principal components analysis of a food-frequency questionnaire (32 wk gestation). Associations of dietary pattern scores (quartiles), and of food groups (frequency of consumption), with the likelihood of B-Pb ≥5 µg/dL identified with adjusted logistic regression (n = 2167 complete cases). Results There was a negative association between the “confectionery” dietary pattern and the likelihood of B-Pb ≥5 µg/dL (OR: 0.62; 95% CI: 0.41, 0.94) in an adjusted model. There were no associations with other dietary patterns. There was a positive association between the food group “all leafy green and green vegetables” and the likelihood of B-Pb ≥5 µg/dL (OR 1.45; 95% CI: 1.04, 2.01). Conversely, the food group “cakes and biscuits” was negatively associated (OR 0.63; 95% CI: 0.43, 0.93). After multiple imputation, there was a positive association of the “healthy” diet pattern and no association of the “confectionery” pattern. Conclusions We found limited evidence of an association between women's typical diet and B-Pb during pregnancy. Our findings do not indicate need to revise dietary guidance for pregnant women, who are advised to adopt a healthy diet in pregnancy, with a variety of foods consumed in moderation.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Taylor

Doerner

Northstone

et al. 2019

The Journal of Nutrition

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“… 39 Consumption of a diet according to WHO recommendations has been associated with lower levels of PFASs and PCBs. 40 41 …”

Section: Discussionmentioning

confidence: 99%

Population attributable risks and costs of diabetogenic chemical exposures in the elderly

Trasande

Lampa²,

Lind

et al. 2016

J Epidemiol Community Health

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BackgroundA previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diabetogenic exposures in the elderly in Europe.MethodsWe leveraged the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (∼1000 participants), which has measured exposure to phthalates; dichlorodiphenyltrichloroethylene; polychlorinated biphenyls (PCBs) and perfluoroalkyl substances to examine their independent contribution to diabetes. We estimated risk reductions assuming identical 25% reductions across levels of 4 selected compounds (PCB 153, monoethylphthalate, dichlorodiphenyldichloroethylene and perfluorononanoic acid), and diabetes costs saved in European men and women if diabetogenic exposures are limited.ResultsReduction of chemical exposures was associated with a 13% (95% CI 2% to 22%) reduction in prevalent diabetes, compared with 40% resulting from an identical (25%) reduction in body mass index (BMI) in cross-sectional analyses. Extrapolating to Europe, 152 481 cases of diabetes in Europe and €4.51 billion/year in associated costs could be prevented, compared with 469 172 cases prevented by reducing BMI.ConclusionsThese findings support regulatory and individual efforts to reduce chemical exposures to reduce the burden and costs of diabetes.

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“…Potential limitations include the measurement error and subsequent misclassification of PCB exposure and the limited number of cases in some stratified analyses, which could influence the lack of observed associations. Although the diet is the major route of exposure to PCBs (>95%) in the general population (Malisch and Kotz, 2014) and various dietary patterns have been associated with serum PCB levels (Ax et al , 2015), additional exposures from other non-dietary sources, such as indoor air PCBs, cannot be excluded. Exposure via inhalation in contaminated buildings constructed in 1950–70, may mainly contribute to the less chlorinated PCB congeners (Bräuner et al , 2016).…”

Section: Discussionmentioning

confidence: 99%

Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort

et al. 2016

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Background:Observational studies on polychlorinated biphenyl (PCB) exposure and hormone-related cancer risk are either inconsistent or lacking. We aimed to assess associations of dietary PCB exposure with breast, endometrial and ovarian cancer risk in middle-aged and elderly women.Methods:We included 36 777 cancer-free women at baseline in 1997 from the prospective population-based Swedish Mammography Cohort. Validated estimates of dietary PCB exposure were obtained via a food frequency questionnaire. Incident cancer cases were ascertained through register linkage.Results:During 14 years of follow-up, we ascertained 1593, 437 and 195 incident cases of breast, endometrial and ovarian cancer. We found no overall association between dietary PCB exposure and any of these cancer forms. The multivariable-adjusted relative risks comparing women in the highest and lowest tertile of PCB exposure were 0.96 (95% confidence interval (CI): 0.75, 1.24), 1.21 (95% CI: 0.73, 2.01) and 0.90 (95% CI: 0.45, 1.79) for breast, endometrial and ovarian cancer. In analyses stratified by factors influencing oestrogen exposure, possibly masking associations with PCBs, indications of higher risks were observed for endometrial cancer.Conclusions:This study suggests that dietary exposure to PCBs play no critical role in the development of breast, endometrial or ovarian cancer during middle-age and old ages.

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Circulating levels of environmental contaminants are associated with dietary patterns in older adults

Abstract: Dietary patterns were associated in diverse manners with circulating levels of environmental contaminants in this elderly Swedish population. Following the WHO dietary recommendations seems to be associated with a lower burden of environmental contaminants.

Cited by 21 publications

References 45 publications

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Dietary Patterns Are Not Consistently Associated with Variability in Blood Lead Concentrations in Pregnant British Women

Population attributable risks and costs of diabetogenic chemical exposures in the elderly

Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort

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