Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome

Carmina, Enrico; Bucchieri, Salvo; Mansueto, Pasquale; Rini, G. B.; Ferin, Michel; Løbo, Rogerio A.

doi:10.1016/j.fertnstert.2008.03.007

Cited by 86 publications

(68 citation statements)

References 29 publications

(20 reference statements)

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“…It has previously been reported that the gene expression and circulating levels of visfatin were increased in women with PCOS compared with age-and BMImatched controls (Tan et al 2006a, Chan et al 2007, Kowalska et al 2007, Panidis et al 2008, Carmina et al 2009, Ozkaya et al 2010, Plati et al 2010, Seow et al 2011, as shown in Table 1. However, several recently published studies did not find a difference in plasma or serum visfatin levels between patients with PCOS and control groups (Guducu et al 2012, Lajunen et al 2012, Olszanecka-Glinianowicz et al 2012.…”

Section: Visfatinmentioning

confidence: 86%

“…Most studies, however, did not find any significant differences in serum leptin levels in women with PCOS when compared with age-and weight-matched controls (Table 1; Chapman et al 1997, Laughlin et al 1997, Mantzoros et al 1997, Micic et al 1997, Rouru et al 1997, Gennarelli et al 1998, Carmina et al 2009. No significant difference was found in circulating leptin levels between the ovulatory and anovulatory PCOS patients either (Carmina et al 2009). Furthermore, a very recent study showed that there was no effect of PCOS on either adipose leptin expression or plasma leptin levels (Svendsen et al 2012).…”

Section: Leptinmentioning

confidence: 93%

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Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Dysfunction of adipose tissue has been implicated in the pathophysiology of PCOS. Increasing evidence shows that the dysregulated expression of adipokines, the secreted products of adipose tissue, plays an important role in the pathology of PCOS. Here, we review the role of several identified adipokines that may act as a link between obesity and PCOS. PCOS also reciprocally influences the profile of adipokines. Insight into the underlying mechanisms will help better understand the pathology of PCOS and identify new therapeutic targets of this syndrome.

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Section: Visfatinmentioning

confidence: 86%

Section: Leptinmentioning

confidence: 93%

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Chen¹,

Jia²,

Qiao³

et al. 2013

Journal of Molecular Endocrinology

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“…serum TNF and IL-6) (Diamanti-Kandarakis et al, 2007b;Guzelmeric et al, 2007;Atamer et al, 2008). They also present clinical features of premature atherosclerosis such as impaired pulse wave velocity (PWV), increased carotid intima media wall thickness (IMT), presence of carotid plaque, and increased coronary artery calcification (Carmina et al, 2008;. Therefore, it is now recognised that treating IR in PCOS patients will effectively treat the symptoms and may also prevent the long-term sequelae of this endocrinopathy (De Leo et al, 2003).…”

Section: Pcos and Obesitymentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

128

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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“…In fact, obesity, predominantly abdominal, is recognized as an important determinant of metabolic risk in these patients (Azziz et al, 2004;Spritzer and Wiltgen, 2007). In PCOS, elevated leptin serum levels have been associated with amount of adipose tissue, waist circumference, insulin resistance, and hyperandrogenemia (Spritzer et al, 2001;Carmina et al, 1999Carmina et al, , 2005, while adiponectin levels have been reported to be decreased (Ardawi and Rouzi, 2005;EscobarMorreale, 2006;Jakubowska et al, 2008;Carmina et al, 2005Carmina et al, , 2009 or unchanged (Orio et al, 2003;Sprangler et al, 2004;Gulcelik et al, 2006). In this paper, we briefly review the emerging evidence linking adipose tissue expression of leptin and adiponectin and serum adipokine levels in women with PCOS.…”

Section: Introductionmentioning

confidence: 97%

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

Lecke¹,

Morsch²,

Spritzer³

2013

Genet. Mol. Res.

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ABSTRACT. We reviewed emerging evidence linking serum levels and adipose tissue expression of leptin and adiponectin in women with polycystic ovary syndrome (PCOS). Previous data obtained by our group from a sample of overweight/obese PCOS women and a control sample of normal weight controls, both stratified by BMI, were reanalyzed. Circulating levels of leptin and adiponectin were determined by commercially available enzyme-linked immunosorbent assays. Adipose tissue total RNA was reserve-transcripted into complementary DNA samples, which were used as templates for quantitative real-time PCR amplification. Positive correlations were found between serum and mRNA levels for both leptin (r = 0.321; P = 0.005) and adiponectin (r = 0.266; P = 0.024). Deter-©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 4292-4296 (2013) Adipose tissue expression in PCOS 4293 mination of leptin and adiponectin serum levels could serve as an indirect method to assess adipocyte production, since leptin and adiponectin are predominantly produced by subcutaneous adipocytes in women.

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Circulating levels of adipose products and differences in fat distribution in the ovulatory and anovulatory phenotypes of polycystic ovary syndrome

Cited by 86 publications

References 29 publications

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

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