Circulating level of macrophage colony-stimulating factor can be predictive for human in vitro fertilization outcome

Salmassi, Ali; Mettler, Liselotte; Jonat, W.; Buck, S.; Koch, Kerstin; Schmutzler, A. G.

doi:10.1016/j.fertnstert.2008.09.083

Cited by 21 publications

(21 citation statements)

References 51 publications

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“…The majority of the cytokines reached their peak levels at the time of OPU, coinciding with the maximal levels of FSH and HCG. In support of our findings, previous studies have found a gradual increase of serum macrophage colony-stimulating factor (M-CSF) and granulocyte colonystimulating factor (G-CSF) throughout ovarian stimulation in IVF cycles (Nishimura et al, 1998;Salmassi et al, 2005;Salmassi et al, 2010). IFN-γ, IL-4 and TNF have been studied after lymphocyte activation with PMA/ionomycin before and after ovarian stimulation (Kalu et al, 2008), and IL-10 has been analyzed in serum during IVF treatment (Wu et al, 2001).…”

Section: Discussionsupporting

confidence: 87%

Immunological status in patients undergoing in vitro fertilisation: responses to hormone treatment and relationship to outcome

Persson

Ekerfelt

Jablonowska

et al. 2012

Journal of Reproductive Immunology

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We aimed to prospectively investigate the paternal antigen-induced cytokine secretion by peripheral blood mononuclear cells (PBMC) in response to hormone treatment in women undergoing in vitro fertilization (IVF) and to examine the predictive value of the cytokine secretion in the outcome of IVF treatment in a pilot study. Twenty-five women were included and IVF treatment was successful for six and unsuccessful for 19 women. Blood samples were collected before IVF treatment, on four occasions during IVF and 4 weeks after embryo transfer. The numbers of Th1-, Th2-and Th17-associated cytokine secreting cells and cytokine levels in cell supernatants were analyzed by enzyme linked immunospot-forming (ELISpot), enzyme-linked immune-sorbent (ELISA) or Luminex assay. None of the cytokines (IFN-γ, IL-4, IL-5, IL-10, IL-12, IL-13, IL-17, TNF and GM-CSF) had any predictive value regarding IVF outcome. The majority of the cytokines reached their peak levels at ovum pickup, suggesting an enhancing influence of the hormonal stimulation. Pregnancy was associated with a high number of IL-4-, IL-5-and IL-13-secreting cells four weeks after ET. In conclusion, the results do not support our hypothesis of a more pronounced peripheral Th1 and Th17 deviation towards paternal antigens in infertile women with an unsuccessful IVF outcome, although this is based on a small number of observations. Thus, a larger study should be conducted to confirm this conclusion. Higher numbers of Th2-associated cytokinesecreting cells in pregnant women four weeks after ET do corroborate the hypothesis of a Th2 deviation during pregnancy.

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Section: Discussionsupporting

confidence: 87%

Immunological status in patients undergoing in vitro fertilisation: responses to hormone treatment and relationship to outcome

Persson

Ekerfelt

Jablonowska

et al. 2012

Journal of Reproductive Immunology

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“…129,130 Moreover, CSF-1 has been therapeutically administered as an adjunct therapy during hormonal ovarian hyperstimulation therapy. 131 Patients with documented unsuccessful responsiveness in previous hyperstimulation cycles were recruited, and CSF-1 treatment was shown to improve follicular development leading to increased numbers of mature oocytes retrieved for subsequent IVF.…”

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confidence: 99%

Macrophages and CSF-1

Jones¹,

Ricardo

2013

Organogenesis

123

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“…Two MCRs contained part of 5p (table 3), that contained the telomerase gene, TERT. A large MCR on 5q (table 3) contained, the proto-oncogene CSF1R (colony stimulating factor 1 receptor precursor) [26], [32] and the growth factor PDGFRB (platelet-derived growth factor receptor), both of which belong to the CSF1/PDGF receptor family of tyrosine-specific protein kinases. CSF1R codes for a cytokine that controls the monocyte-macrophage system and PDGFRB is involved in various myeloid malignancies.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide High-Resolution aCGH Analysis of Gestational Choriocarcinomas

et al. 2012

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Eleven samples of DNA from choriocarcinomas were studied by high resolution CGH-array 244 K. They were studied after histopathological confirmation of the diagnosis, of the androgenic etiology and after a microsatellite marker analysis confirming the absence of contamination of tumor DNA from maternal DNA. Three cell lines, BeWo, JAR, JEG were also studied by this high resolution pangenomic technique. According to aCGH analysis, the de novo choriocarcinomas exhibited simple chromosomal rearrangements or normal profiles. The cell lines showed various and complex chromosomal aberrations. 23 Minimal Critical Regions were defined that allowed us to list the genes that were potentially implicated. Among them, unusually high numbers of microRNA clusters and imprinted genes were observed.

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Circulating level of macrophage colony-stimulating factor can be predictive for human in vitro fertilization outcome

Cited by 21 publications

References 51 publications

Immunological status in patients undergoing in vitro fertilisation: responses to hormone treatment and relationship to outcome

Immunological status in patients undergoing in vitro fertilisation: responses to hormone treatment and relationship to outcome

Macrophages and CSF-1

Genome-Wide High-Resolution aCGH Analysis of Gestational Choriocarcinomas

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