Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty

Pita, Jimena; Barrios, Vicente; Gavela-Pérez, Teresa; Martos‐Moreno, Gabriel Ángel; Muñoz-Calvo, M.T.; Pozo, Juan Ignacio; Rovira, Adela; Argente, Jesús; Soriano‐Guillén, Leandro

doi:10.1016/j.peptides.2011.07.016

Cited by 44 publications

(59 citation statements)

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“…Pita et al [42] found that obese prepubertal girls had higher circulating kisspeptin levels than normal weight prepubertal girls. Our study also showed that obese/overweight adolescent girls had notably higher serum kisspeptin concentrations than normal weight adolescent girls, and they were positively correlated with BMI, WC, and weight in girls.…”

Section: Discussionmentioning

confidence: 99%

The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages

Zhu

Pan

et al. 2016

International Journal of Endocrinology

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The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P < 0.05). Conversely, serum kisspeptin levels of boys were higher in T4 and T5 stages than those in T1 stage, while its levels of girls were the highest in T2 stage, 21.4% higher than those in T1 stage (P < 0.05). Both leptin and kisspeptin levels were positively correlated with BMI, WC, and weight in all boys and girls (all P < 0.05). In conclusion, kisspeptin levels were firstly found to be notably changed in pubertal stages and nutritional status in Chinese children and adolescents with a significant sexual dimorphism. Obese/overweight girls had higher kisspeptin levels, and there was a positive correlation between kisspeptin and FSH and LH and obesity-related parameters in all boys and girls.

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Section: Discussionmentioning

confidence: 99%

The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages

Zhu

Pan

et al. 2016

International Journal of Endocrinology

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“…Serum kisspeptin in adult, sexually mature women was significantly elevated when compared to adult men of similar age in two studies of different populations from distinct ethnic backgrounds (Pita et al, 2011a,b). This endorses the sexually dimorphic character of kisspeptin differences, as opposed to other ethnic-specific genetic factors.…”

Section: Sexual Dimorphism Of Kisspeptin Expression and Association Tmentioning

confidence: 91%

“…This dimorphism has been associated to the onset of puberty and fertility in some species (Wray and Gainer, 1987; Kauffman et al, 2007a,b; Homma et al, 2009; Kauffman et al, 2009; Bakker et al, 2010; Hrabovszky et al, 2010; Jayasena et al, 2011; Pita et al, 2011a). Prenatal exposure to sex steroids may account for at least part of the sexual dimorphism in kisspeptin, and lack of kisspeptin dimorphism can lead to irreversible abnormalities of the sexual behavior in some species (Kauffman et al, 2007a,b; Gonzalez-Martinez et al, 2008).…”

Section: Sexual Dimorphism Of Kisspeptin Expression and Association Tmentioning

confidence: 99%

“…Kisspeptin neurons, kisspeptin expression and/or serum kisspeptin have been consistently shown to be sexually dimorphic in many species, including humans (Wray and Gainer, 1987; Kauffman et al, 2007a,b; Homma et al, 2009; Kauffman et al, 2009; Bakker et al, 2010; Hrabovszky et al, 2010; Jayasena et al, 2011; Pita et al, 2011a). This dimorphism has been associated to the onset of puberty and fertility in some species (Wray and Gainer, 1987; Kauffman et al, 2007a,b; Homma et al, 2009; Kauffman et al, 2009; Bakker et al, 2010; Hrabovszky et al, 2010; Jayasena et al, 2011; Pita et al, 2011a).…”

Section: Sexual Dimorphism Of Kisspeptin Expression and Association Tmentioning

confidence: 99%

“…Prenatal exposure to sex steroids may account for at least part of the sexual dimorphism in kisspeptin, and lack of kisspeptin dimorphism can lead to irreversible abnormalities of the sexual behavior in some species (Kauffman et al, 2007a,b; Gonzalez-Martinez et al, 2008). Also, circulating kisspeptin has been reported to be sexually dimorphic in humans, with women having significantly elevated kisspeptin when compared to men (Wray and Gainer, 1987; Kauffman et al, 2007a, 2009; Hrabovszky et al, 2010; Pita et al, 2011a,b). Expression of the kisspeptin receptor has also been reported to be sexually dimorphic in rats (Navarro et al, 2004a), Rhesus monkeys (Shahab et al, 2005), and teleost fish cobia (Mohamed et al, 2007), which demonstrates phyllogenetic conservation of this effect as well.…”

Section: Sexual Dimorphism Of Kisspeptin Expression and Association Tmentioning

confidence: 99%

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A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals

Bianco¹

2012

Front. Endocrin.

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The major determinants of the variability in pubertal maturation are reported to be genetic and inherited. Nonetheless, nutritional status contributes significantly to this variability. Malnutrition delays puberty whereas obesity has been associated to a rise in Idiopathic Central Precocious Puberty (ICPP) in girls. However, epidemiology data indicate that contribution of obesity to early puberty varies significantly among ethnic groups, and that obesity-independent inheritable genetic factors are the strongest predictors of early puberty in any ethnic group. In fact, two human mutations with confirmed association to ICPP have been identified in children with no history of obesity. These mutations are in kisspeptin and kisspeptin receptor, a ligand/receptor pair with a major role on the onset of puberty and female cyclicity after puberty. Progressive increases in kisspeptin expression in hypothalamic nuclei known to regulate reproductive function has been associated to the onset of puberty, and hypothalamic expression of kisspeptin is reported to be sexually dimorphic in many species, which include humans. The hypothalamus of females is programmed to express significantly higher levels of kisspeptin than their male counterparts. Interestingly, incidence of ICPP and delayed puberty in children is markedly sexually dimorphic, such that ICPP is at least 10-fold more frequent in females, whereas prevalence of delayed puberty is about 5-fold higher in males. These observations are consistent with a possible involvement of sexually dimorphic kisspeptin signaling in the sexual dimorphism of normal puberty and of pubertal disorders in children of all ethnicities. This review discusses the likelihood of such associations, as well as a potential role of kisspeptin as the converging target of environmental, metabolic, and hormonal signals, which would be integrated in order to optimize reproductive function.

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The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals

Abbara

Ratnasabapathy

Jayasena

et al. 2013

Advances in Experimental Medicine and Biology

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The Kiss1 gene encodes a 145-amino acid pre-peptide, kisspeptin, which is cleaved into smaller peptides of 54, 14, 13, and 10 amino acids. This chapter reviews in detail the effects of kisspeptin on gonadotropin secretion in non-human mammals. Studies of kisspeptin's effects have included both acute and chronic administration regimens via a number of administration routes. Acute kisspeptin stimulates gonadotropin secretion in a wide range of species of non-human mammals, including rats, mice, hamsters, sheep, pigs, goats, cows, horses, and monkeys. In general, the stimulatory effect of kisspeptin treatment is more pronounced for LH than FSH secretion. Kisspeptin is thought to exert its stimulatory effects on LH and FSH release via stimulation of GnRH release from the hypothalamus, since pre--administration of a GnRH antagonist prevents kisspeptin's stimulation of gonadotropin secretion. Although the kisspeptin receptor is also expressed on anterior pituitary cells of some species, and incubation of anterior pituitary cells with high concentrations of kisspeptin can stimulate in vitro LH release, the contribution of direct effects of kisspeptin on the pituitary is thought to be negligible in vivo. Continuous kisspeptin administration results in reduced sensitivity to the effects of kisspeptin, in some species. This desensitization is thought to occur at the level of the kisspeptin receptor, since the response of the pituitary gland to exogenous GnRH is maintained. Overall, the findings discussed in this chapter are invaluable to the understanding of the reproductive role of kisspeptin and the potential therapeutic uses of kisspeptin for the treatment of fertility disorders.

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Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty

Cited by 44 publications

References 38 publications

The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages

The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages

A potential mechanism for the sexual dimorphism in the onset of puberty and incidence of idiopathic central precocious puberty in children: sex-specific kisspeptin as an integrator of puberty signals

The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals

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