Circulating irisin levels are associated with lipid and uric acid metabolism in a Chinese population

Abstract

Irisin is a novel hormone secreted by skeletal muscle after exercise, which may ameliorate insulin resistance. In this study, we aimed to explore the relationship between circulating irisin levels and type 2 diabetes mellitus (T2DM) as well as related metabolic traits in a Chinese population. A total of 203 subjects were recruited. Of these, 68 subjects with normal glucose tolerance (NGT), 63 subjects with impaired glucose regulation (IGR) and 72 subjects with new-onset T2DM. Circulating irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). Detailed clinical investigations and biochemistry measurements were carried out in all of the subjects. Multivariate linear regression analysis was performed to assess the association between irisin levels and related metabolic characteristics. All subjects were classified into normal weight and overweight/obese subgroups according to body mass index (BMI). No significant differences in circulating irisin levels were identified among the three groups (P = 0.9741). After adjusting for covariates, multiple linear regression analysis revealed that serum irisin level was independently and significantly associated with total cholesterol (P = 0.0005), low-density lipoprotein cholesterol (P = 0.0014), fasting fatty acids (P = 0.0402) and uric acid (P = 0.0062). By dividing the serum irisin levels into three tertile groups, the values of total cholesterol, low-density lipoprotein cholesterol, fasting fatty acids and uric acid were all increased significantly with the increase of irisin (P < 0.05). Moreover, serum irisin levels remain closely related to total cholesterol in both normal weight and overweight/obese subgroups. Our study suggests that circulating irisin concentrations are significantly associated with lipid and uric acid metabolism in a Chinese population.

Low Irisin Levels in Patients with Type 2 Diabetes Mellitus without Current Treatment: A Systematic Review

“…These results were not supported by Tang et al [25] research which did not notice any significant differences between these groups.…”

“…Other three researches [22,25,26] did not evidence significant differences between diabetic patients and control groups.…”

“…Three studies (Choi et al [6], Xie et al [22], Tang et al [25]) used the criteria defined by the World Health Organization (WHO) to characterize the cases of diabetes mellitus; other three (Sanchis Gomar et al [26], Wang et al [20], Zhang et al [27] used the American Diabetes Association criteria, and two of them (Kurdiova et al [12], Xiang et al [21]) did not explain the chosen parameters.…”

“…Seven studies (Choi et al [6], Kurdiova et al [12], Wang et al [20], Xiang et al [21], Xie et al [22], Tang et al [25], Zhang et al [27]) included on its sample only patients newly diagnosed and just Sanchis Gomar et al [26] applied as selection criteria the absence of current treatment like insulin and/ or statins to compose the sample. The main results found on the review are listed on the (Table 2).…”

Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women

“…In addition, the author reported a significant direct correlation between irisin and uric acid in overweight/obese group. 38 Uric acid may have triggered the ROS generation through various mechanisms, and this may, in turn, stimulated irisin and/or in turn betatrophin through activating p38 MAPK.…”