Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

Anastasilakis, Athanasios D.; Polyzos, Stergios A.; Saridakis, Zacharias G.; Kynigopoulos, Georgios; Skouvaklidou, Elpida C.; Molyvas, Dimitrios; Vasiloglou, Maria F.; Apostolou, Aggeliki; Karagiozoglou–Lampoudi, Thomais; Siopi, Aikaterina; Mougios, Vassilis; Chatzistavridis, Panagiotis; Panagiotou, Grigorios; Filippaios, Andreas; Delaroudis, S.; Mantzoros, Christos S.

doi:10.1210/jc.2014-1367

Cited by 150 publications

(194 citation statements)

References 27 publications

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“…Also, the browning formation that Irisin may cause could lead to reduced weight gain, up-regulated insulin sensitivity, reduced risk of diabetes type II and other metabolic disorders as animal studies indicate [89][90][91][92][93] , as well as increase daily resting energy expenditure in humans 94,95 . However, the secondary outcomes of our systematic review shows that even when Irisin was measured with the same ELISA (PP, EK-067-52) there was no relationship 22 or a positive relationship with resting energy expenditure 37 , and no association 72 or a positive association with BMI 71 . This specific ELISA kit (PP, EK-067-52) has been tested by a previous study for validity 27 , which showed it to be invalid for circulating Irisin identification.…”

Section: Quality Of Evidence and Limitationsmentioning

confidence: 77%

“…This specific ELISA kit (PP, EK-067-52) has been tested by a previous study for validity 27 , which showed it to be invalid for circulating Irisin identification. Furthermore, Irisin measured with ELISA from the same manufacturer (Phoenix Pharmaceuticals) showed either no relationship 72 or a positive relationship with waist circumference 49 . This evidence shows inconsistent results of the relationship of Irisin with indices indicating the therapeutic role of the protein, even though the Irisin identification methods that used were identical.…”

Section: Quality Of Evidence and Limitationsmentioning

confidence: 95%

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Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

et al. 2017

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Exercise may activate a brown adipose-like phenotype in white Background: adipose tissue. The aim of this systematic review was to identify the effects of physical activity on the link between peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a) and fibronectin type III domain-containing protein 5 (FNDC5) in muscle, circulating Irisin and uncoupling protein one (UCP1) of white adipocytes in humans. Two Methods: databases (PubMed 1966 to 08/2016 and EMBASE 1974 to 08/2016 were searched using an appropriate algorithm. We included articles that examined physical activity and/or exercise in humans that met the following criteria: a) PGC-1a in conjunction with FNDC5 measurements, and b) FNDC5 and/or circulating Irisin and/or UCP1 levels in white adipocytes. We included Results: 51 studies (12 randomised controlled trials) with 2474 participants. Out of the 51 studies, 16 examined PGC-1a and FNDC5 in response to exercise, and only four found increases in both PGC-1a and FNDC5 mRNA and one showed increased FNDC5 mRNA. In total, 22 out of 45 studies that examined circulating Irisin in response to exercise showed increased concentrations when ELISA techniques were used; two studies also revealed increased Irisin levels measured via mass spectrometry. Three studies showed a positive association of circulating Irisin with physical activity levels. One study found no exercise effects on UCP1 mRNA in white adipocytes.The Conclusions: effects of physical activity on the link between PGC-1a, FNDC5 mRNA in muscle and UCP1 in white human adipocytes has attracted little scientific attention. Current methods for Irisin identification lack precision and, therefore, the existing evidence does not allow for conclusions to be made regarding Irisin responses to physical activity. We found a contrast between standardised review methods and accuracy of the measurements used. This should be considered in future systematic reviews.

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Section: Quality Of Evidence and Limitationsmentioning

confidence: 77%

Section: Quality Of Evidence and Limitationsmentioning

confidence: 95%

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

et al. 2017

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“…found that circulating irisin has a day-night variation with the lowest levels at 6:00 a.m. and the highest ones at 9:00 p.m. However, the blood collection was performed consistently at the same time of the day for individual participants (16). The minimum detectable level was 27.85 ng/mL.…”

Section: Determination Of Circulating Irisin and Other Biochemical Mementioning

confidence: 96%

New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters

Trombeta

Prestes

Nascimento

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Patients infected with the human immunodeficiency virus (HIV) have an increased risk of metabolic disorders and alterations on irisin levels. Therefore, the purpose of the current investigation was to quantify the circulating irisin concentration in HIV-infected subjects under highly active antiretroviral therapy and to determine possible correlations between irisin levels with fat mass, fat-free mass, body mass index (BMI), and muscle strength. Subjects and methods: Cross-sectional study of 10 men (36.7 ± 11.3 years) and 10 women (42.5 ± 10.3 years) infected with HIV, recruited from the Specialized Service Center in the State Center of Reference for High and Medium Complexity. Blood samples were collected to determine plasma irisin levels, glucose, HDL, total cholesterol, triglycerides, and LDL. Body composition (fat mass, fat-free mass) and anthropometrics (body mass index; BMI) were measured by bioelectrical impedance. Muscle strength was assessed using a mechanic hand dynamometer and one maximum repetition tests. Results: Irisin levels correlated positively with fat mass (r = 0.67; p = 0.001) and BMI (r = 0.48; p = 0.036). In contrast, there was an inverse correlation between irisin levels and fat-free mass (r = -0.41; p = 0.008) and five strength parameters: right hand grip (r = -0.46; p = 0.044); left hand grip (r = -0.50; p = 0.027), relative hand grip (r = -0.79; p = 0.001), bench press (r = -0.58; p = 0.009), leg press (r = -0.40; p = 0.085), and biceps curl (r = -0.059; p = 0.009). Conclusion: Irisin levels correlated positively with body fat and negatively with fat-free mass and strength parameters in HIV-infected patients. Female patients infected with HIV receiving highly active antiretroviral therapy have higher levels of irisin compared with men in a similar circumstance. Arch Endocrinol Metab. 2017;61(3):382-90.

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“…However, there are discrepancies regarding the relation of irisin especially with obesity and T2DM. In some studies, a positive association was detected between irisin levels and BMI (24,25,26), while others reported null (27,28).In agreement with Tanisawa et al (29) showed that the Gallele of rs3480 was associated with increased insulin resistance and its complications. In contrast to our results, Nasser M et al ., (30) reported that The rs3480 GG associates with decreased risk of obesity (p = 0.005; odds ratio: 0.48) and lower body mass index (BMI).while rs1746661 variant is associated with elevated triglycerides.…”

Section: Discussionmentioning

confidence: 53%

Irisin Gene Polymorphism Rs3480 and Rs1746661and Obesity in Egyptian Populations

Allah¹,

Gayed²,

Hammoudah³

et al. 2017

IOSR JBB

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and genotyping of rs3480 (A/G) and rs1746661 (G/T) gene polymorphisms. There was a significant statistical difference between the two groups regarding genotype frequency of FNDC5 (Irisin precursor) rs3480 (A/G) and rs 174661 (G/T). Regarding rs3480 (A/G), there was a high frequency of AA genotype and A allele among the control group, while GG genotype and G allele had the highest frequency among obese group. Regarding rs1746661 (G/T), there was a high frequency of GG genotype and G allele among the control group, while TT genotype and T allele had the highest frequency among obese group. Multivariate logistic regression for risk of obesity showed that the most common risk factor is

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Circulating Irisin in Healthy, Young Individuals: Day-Night Rhythm, Effects of Food Intake and Exercise, and Associations With Gender, Physical Activity, Diet, and Body Composition

Abstract: In healthy, young individuals, circulating irisin displays a day-night rhythm, is correlated with lean body mass, and increases acutely after exercise.

Cited by 150 publications

References 27 publications

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review

New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters

Irisin Gene Polymorphism Rs3480 and Rs1746661and Obesity in Egyptian Populations

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