Circulating irisin and adiponectin levels are positively associated with atrial fibrillation

Alzoughool, Foad; Atoum, Manar; Abu-Awad, Aymen; Abdelqader, Rana; Alanagreh, Lo’ai; Hatmal, Ma’mon M.

doi:10.23736/s0393-3660.18.03963-3

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The role of adropin and irisin was investigated in patients with T2DM, as long-term complications of diabetes include coronary artery disease, diabetic retinopathy and impaired renal functions [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

Alzoughool

Hourani

Atoum

et al. 2021

NHA

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BACKGROUND/AIM: The newly described proteins adropin and irisin are a highly conserved polypeptide that plays essential roles in metabolic and energy homeostasis, insulin resistance, and fat browning. The aim of this study is to evaluate the circulating levels of serum adropin and irisin in type 2 diabetes mellitus (T2DM) patients and also to elucidate possible relationships between serum adropin and irisin levels with anthropometric obesity indices and biochemical parameters. SUBJECTS AND METHODS: Single-center prospective observational study included 90 T2DM patients referred to the diabetes outpatient clinic. Height, weight, and waist circumference (WC) were measured. Body mass index (BMI) and waist to height ratio (WHtR) were calculated. Fasting blood glucose, glycosylated hemoglobin, serum lipids, creatinine, urea, and blood urea nitrogen were evaluated. Estimated glomerular filtration rate (GFR) was calculated, serum adropin and irisin were evaluated. RESULTS: The results showed a significant positive correlation between adropin and irisin in females but not in males (r = 0.311; P = 0.042). In males’ group, serum adropin levels showed significant negative correlation with serum glucose (–0.423, P = < 0.05), HbA1C (–0.364, P = < 0.05), and GFR (–0.355, P = < 0.05). In contrast, creatinine was showed a significant positive correlation with adropin in males (0.381, P = < 0.05). In females’ group, adropin showed a significant negative correlation with weight (–0.371, P = < 0.05), BMI (–0.349, P = < 0.05), WC (–0.402, P = < 0.01), and WHtR (–0.398, P = < 0.01). Contrary, in males’ group, serum irisin levels showed significant positive correlation with weight (0.338, P = < 0.05), BMI (0.332, P = < 0.05), WC (0.409, P = < 0.01), and WHtR (0.432, P = < 0.01). CONCLUSION: This study demonstrated that, in T2DM patients, circulating serum adrpoin correlated negatively with anthropometric obesity indices of obesity in females, while serum irisin was positively correlated with anthropometric obesity indices of obesity in males.

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Section: Introductionmentioning

confidence: 99%

Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

Alzoughool

Hourani

Atoum

et al. 2021

NHA

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“…Recently, muscles were recognized as an endocrine organ releasing myokines [1]. Myokines are important in regulating multiphysiological and metabolic pathways to induce metabolism through communication with several tissues such as pancreas, liver, and many more [2,3]. Irisin is a novel myokine hormone secreted by myocytes that have been suggested to mediate some of the beneficial effects of exercise such as, prevents weight gain and metabolic dysfunction [1].…”

Section: Introductionmentioning

confidence: 99%

The optimal therapeutic irisin dose intervention in animal model: A systematic review

et al. 2020

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Background and Aim: Irisin, a novel myocyte-secreted hormone, was proposed to mediate some of the beneficial effects of exercise such as browning of adipocytes, thermogenesis, and metabolic homeostasis. Recently, several animals' models' studies have been performed to investigate the therapeutic impact of irisin in several disorders. Several interventional trials used different doses. However, optimum dose was not determined. This systematic review aims to identify the optimal dose of interventional irisin in mice and rat animal models. Materials and Methods: Online databases PubMed, Google Scholar, and Springer were systematically searched from 2012 to 2019. The words searched were irisin, irisin and animal model, physical activity, and irisin and irisin dosage. Non-irisin doses, in vitro studies, and factors influencing irisin levels were excluded. Results: Eleven of the total 391 qualifying studies were included. A daily injection of 500 μg/kg irisin may be the optimum dose of effect in mice and rats. Conclusion: More studies are required to determine the optimum dose of irisin to be used as a therapeutic intervention based on animal model.

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Exerkine β-aminoisobutyric acid protects against atrial structural remodeling and atrial fibrillation in obesity via activating AMPK signaling and improving insulin sensitivity

Qin,

Liu,

Jin

et al. 2024

Biomedicine & Pharmacotherapy

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Circulating irisin and adiponectin levels are positively associated with atrial fibrillation

Cited by 3 publications

References 31 publications

Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

The optimal therapeutic irisin dose intervention in animal model: A systematic review

Exerkine β-aminoisobutyric acid protects against atrial structural remodeling and atrial fibrillation in obesity via activating AMPK signaling and improving insulin sensitivity

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