Circulating intermediate monocytes and toll-like receptor 4 correlate with low-voltage zones in atrial fibrillation

Suehiro, Hideya; Fukuzawa, Koji; Yoshida, Naofumi; Kiuchi, Kunihiko; Takami, Mitsuru; Akita, Tomomi; Tabata, Toshihide; Takemoto, Makoto; Sakai, Jun; Nakamura, Toshihiro; Yatomi, Atsusuke; Takahara, Hiroyuki; Sonoda, Yusuke; Nakasone, Kazutaka; Yamamoto, K.; Suzuki, Atsushi; Yamashita, Tomoya; Hirata, Ken‐ichi

doi:10.1007/s00380-020-01647-4

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…Interestingly, intermediate monocytes correlated negatively with LAA flow velocity, and positively correlated with BNP levels. We recently reported that the low‐voltage area during SR was not associated with intermediate monocytes in non‐PAF patients 18 . This discrepancy might be caused by the monocyte elevation after direct current (DC) shocks, which resulted in an overestimation of monocyte counts and the limitation of the LVZ mapping based on the bipolar voltage.…”

Section: Discussionmentioning

confidence: 99%

Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation

Suehiro

Kiuchi

Fukuzawa

et al. 2021

Cardiovasc electrophysiol

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Background Inflammation, such as that associated with intermediate CD14++CD16+ monocytes and atrial structural remodeling (SRM), may be important in the recurrence of atrial fibrillation (AF) after catheter ablation. However, the relationship between the intermediate CD14++CD16+ monocytes, SRM, and AF recurrence is unclear. Methods Twenty‐four patients with AF were enrolled. The proportion of intermediate monocytes (PIM) was assessed before ablation by flow cytometry. As a surrogate marker of SRM, the volume ratio (VR) of signal intensity greater than 1 standard deviation on late‐gadolinium enhancement magnetic resonance imaging (LGE‐MRI) was calculated. We investigated whether PIM correlated with SRM on LGE‐MRI and determined the optimal cutoff value for predicting AF recurrence. Results Univariate analysis revealed positive correlations between PIM and BNP with SRM (PIM: r = .593, p = .002; BNP: r = .567, p = .004). Multivariable analysis revealed that PIM was independently associated with VR on LGE‐MRI (β = .522; p = .033). The finding of an area under the receiver operating characteristic curve of 0.750 revealed that a VR ≥ 13.3% on LGE‐MRI as the optimal cutoff value to predict AF recurrence with 80% sensitivity and 71% specificity, which was associated with PIM ≥ 10.0%. Conclusion Intermediate monocytes were significantly positively correlated with SRM. PIM ≥ 10% was associated with a VR ≥ 13.3% on LGE‐MRI, which predicted AF recurrence after catheter ablation.

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Section: Discussionmentioning

confidence: 99%

Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation

Suehiro

Kiuchi

Fukuzawa

et al. 2021

Cardiovasc electrophysiol

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“…In AF patients, the proportion of intermediate monocytes was higher compared with the control group [ 46 ], especially in those with low-voltage zones [ 47 ]. Furthermore, the activation of monocytes, more specifically their enhanced migration ability, is crucial in the pathogenesis of atrial remodeling in AF patients [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Analysis of Competing Endogenous RNA Network and Immune Infiltration in Atrial Fibrillation

et al. 2022

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Background. There is still no clear understanding of the pathogenesis of atrial fibrillation (AF). For this purpose, we used integrated analysis to uncover immune infiltration characteristics and investigated their relationship with competing endogenous RNA (ceRNA) network in AF. Methods. Three AF mRNA data sets (GSE14975, GSE79768, and GSE41177) were integrated using the SVA method from Gene Expression Omnibus (GEO). Together with AF circRNA data set (GSE129409) and miRNA data set (GSE70887) from GEO database, we built a ceRNA network. Then hub genes were screened by the Cytoscape plug-in cytoHubba from a protein-protein interaction (PPI) network. As well, CIBERSORT was employed to investigate immune infiltration, followed by Pearson correlation coefficients to unravel the correlation between AF-related infiltrating immune cells and hub genes. Ulteriorly, circRNA-miRNA-mRNA regulatory axises that could be immunologically related to AF were obtained. Results. Ten hub genes were identified from the constructing PPI network. The immune infiltration analysis revealed that the number of monocytes and neutrophils was higher, as well as the number of dendritic cells activated and T cells regulatory (Tregs) was lower in AF. Seven hub genes (C5AR1, CXCR4, HCK, LAPTM5, MPEG1, TLR8, and TNFSF13B) were associated with those 4 immune cells ( P < 0.05 ). We found that the circ_0005299–miR-1246–C5AR1 and circRNA_0079284-miR-623-HCK/CXCR4 regulatory axises may be associated with the immune mechanism of AF. Conclusion. The findings of our study provide insights into immuno-related ceRNA networks as potential molecular regulators of AF progression.

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“…Patients with LVA area

20% have been shown to have higher plasma soluble ST2 which has been shown to be an independent predictor of atrial LVA presence [ 22 ]. Similarly, inflammatory factors have been shown to be a predictor of LVA existence, probably because inflammation is involved in the development of LVA [ 23 ]. Patients with LVA had a larger proportion of intermediate monocytes and higher expression levels of Toll-like receptor-4.…”

Section: How To Predict the Existence Of Lvamentioning

confidence: 99%

Research Progress of Low-Voltage Areas Associated with Atrial Fibrillation

Gu,

Shao,

et al. 2023

Rev. Cardiovasc. Med.

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Atrial fibrosis is an independent predictor of the recurrence of atrial fibrillation (AF) after catheter ablation. Low-voltage areas (LVA) measured during catheter ablation for AF are a commonly used surrogate for the presence of atrial fibrosis. LVA are associated with clinical outcomes and comorbidities and have links to triggering sites for AF. Several trials have shown promising data of targeting ablation in LVA, however the results have been mixed. This article will review the role of LVA in the prediction of adverse events in AF patients, including stroke, how to predict the presence of LVA, and the impact of LVA ablation on the recurrence of AF.

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Circulating intermediate monocytes and toll-like receptor 4 correlate with low-voltage zones in atrial fibrillation

Cited by 4 publications

References 28 publications

Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation

Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation

Bioinformatics Analysis of Competing Endogenous RNA Network and Immune Infiltration in Atrial Fibrillation

Research Progress of Low-Voltage Areas Associated with Atrial Fibrillation

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