Circulating Inflammatory Biomarkers mediates the causal effect of Aging on Female Pelvic Organ Prolapse: Mendelian Randomization Analysis
Xiaoyu Huang,
Ya Xiao,
Mao Chen
et al.
Abstract:Aims
Female pelvic organ prolapse (POP) is a disease associated with aging and inflammation, though it is not determined that aging and inflammation are causative factors. The purpose of this study was to evaluate the causal effects of aging and inflammatory factors on female pelvic organ prolapse (POP).
Methods
Significant genetic variables were evaluated by assessing genome-wide association study (GWAS) data for POP and 5 age biomarkers (GrimAge, HorvathAge, HannumAge, PhenoAge, and leukocyte telomere leng… Show more
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