Circulating immune complexes in cardiac disease

Gallagher, Patrick J.; Jones, Deborah; Casey, Cecily; Sharratt, Geoffrey P.

doi:10.1016/0021-9150(82)90118-6

Cited by 15 publications

(3 citation statements)

References 7 publications

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“…14' 19"2~' 33 A high incidence of CIC has previously been found in patients with various vascular disorders, 8 particularly in patients with acute myocardial infarction. 7,9,28 In the present study, two of the three CIC-positive hematoma patients were hypertensive and had previously suffered a vascular accident. Of the 13 CIC-positive aneurysm patients, five were hypertensive and three of these had previously suffered a major cerebral stroke.…”

Section: O M P L E M E N T Activationmentioning

confidence: 58%

Immune complexes and complement activation following rupture of intracranial saccular aneurysms

Østergaard¹,

Kristensen²,

Svehag³

et al. 1987

Journal of Neurosurgery

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Circulating immune complexes (CIC) and complement activation (plasma C3d levels) were monitored during a 2-week period in patients with ruptured cerebral aneurysms and also in patients with cerebral hematoma unrelated to saccular aneurysms. Thirteen of 18 aneurysm patients were found to have CIC on admission as compared to three of 21 healthy blood donors (p less than 0.001). The presence of CIC in aneurysm patients was associated with a poor prognosis. Eight of nine patients who developed angiographic vasospasm had CIC on admission compared with one of four without vasospasm. Patients with vasospasm showed a twofold increase in plasma C3d levels at the time when the spasm occurred, whereas no significant changes in the C3d concentration could be demonstrated in aneurysm patients without spasm or in patients with hematoma unrelated to aneurysm rupture. These findings suggest that immunological processes involving complement-activating immune complexes are involved in the pathogenesis of cerebral vasospasm following rupture of saccular aneurysms.

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Section: O M P L E M E N T Activationmentioning

confidence: 58%

Immune complexes and complement activation following rupture of intracranial saccular aneurysms

Østergaard¹,

Kristensen²,

Svehag³

et al. 1987

Journal of Neurosurgery

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“…Early studies to investigate the potential damaging effects of CICs were cross-sectional studies in patients with various vascular disorders, predominantly acute myocardial infarction. 75,[77][78][79][80] These studies found that CICs were not specific for any particular vascular disorder, but their presence in the different vascular disorders suggests a potential proatherogenic effect.…”

Section: Circulating Ics: Their Presence In Patients With Cvdmentioning

confidence: 99%

The Role of Immune Complexes in Atherogenesis

2010

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Atherosclerosis is now recognized as a chronic inflammatory disease and is characterized by features of inflammation at all stages of its development. It also appears to display elements of autoimmunity, and several autoantibodies including those directed against oxidized low-density lipoprotein (ox-LDL) and heat shock proteins (Hsps) have been identified in atherosclerosis. Immune complexes (ICs) may form between these antigens and autoantibodies and via Fc receptor signaling and complement activation may modulate the inflammation in atherosclerosis. Antibody isotype may direct the role that ICs play in atherogenesis, immunoglobulin G (IgG) being potentially pro-atherogenic and immunoglobulin M (IgM) playing a protective role. Therapeutic options targeting complement activation and those which are potentially Fc-receptor mediated have been investigated in animal models, though targeting Fc receptor signaling is an area that needs further investigation.

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“…Immune complexes have been implicated in the pathogenesis of many diseases, including acute as well as chronic coronary heart disease (CHD). 17,18 We wished to determine if vasectomized men were more likely to have circulating antisperm antibodies and immune complexes than their age-matched controls. Furthermore, we assessed whether vasectomized men who had experienced a coronary event were more or less likely to have antisperm antibodies or immune complexes.…”

Section: Introductionmentioning

confidence: 99%

Antisperm Antibodies and Circulating Immune Complexes of Vasectomized Men With and Without Coronary Events

Alexander

Fulgham

Plunkett

1986

American Journal of Reproductive Immunology and Microbiology

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We compared antisperm antibody and circulating immune complex (CIC) levels in serum samples from 101 vasectomized and 101 normal age-matched nonvasectomized men; 31 of each group had histories of coronary heart disease (CHD). Vasectomy and CHD status were treated as categorical independent variables in the two-way analysis of variance. Elevations of both systolic and diastolic blood pressures were significantly associated with age and body mass index but not vasectomy. Antisperm antibodies (immobilizing and agglutinating) were significantly associated with vasectomy (P less than or equal to .001); the incidences were similar in men with and without CHD. The CICs were significantly associated with vasectomy in a Staphylococcus aureus (FcSa) CIC assay (P less than or equal to .001) and a Raji cell CIC assay (P less than or equal to .05). A third CIC assay, the Clq binding assay, did not reveal a difference between any subgroups. Generally, CICs occurred more frequently in the CHD group by the FcSa assay and particularly the Raji cell assay (P less than or equal to .001). In summary, vasectomized men had a higher incidence and higher levels of circulating antisperm autoantibodies and CICs than did age-matched controls.

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Circulating immune complexes in cardiac disease

Cited by 15 publications

References 7 publications

Immune complexes and complement activation following rupture of intracranial saccular aneurysms

Immune complexes and complement activation following rupture of intracranial saccular aneurysms

The Role of Immune Complexes in Atherogenesis

Antisperm Antibodies and Circulating Immune Complexes of Vasectomized Men With and Without Coronary Events

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