Circulating Immune Complexes and Anti-IgG Antibodies in Mucocutaneous Leishmaniasis *

Desjeux, P.; Santoro, F; Afchain, D.; Loyens, Marc; Caprón, A

doi:10.4269/ajtmh.1980.29.195

Cited by 28 publications

(8 citation statements)

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“…Interestingly, mucocutaneous leishmaniasis patients had higher antilaminin antibody levels than patients with localized cutaneous lesions, as has also been described for total immunoglobulin and antiparasite antibody levels (5,6,8,18).…”

Section: Resultssupporting

confidence: 58%

Antibodies to laminin in American cutaneous leishmaniasis

Avila¹,

Rojas²,

Rieber³

1984

Infect Immun

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We found that serum samples from patients with different clinical forms of American cutaneous leishmaniasis (ACL) contained immunoglobulin G and immunoglobulin M antibodies which reacted with laminin but not with various other purified connective tissue components, such as collagen types I, III, IV, and V and fibronectin. Eighty-one percent of ACL patients had high antilaminin antibody levels, with a relationship existing between ACL ulcers and antibody levels. This was not, however, the case with patients having treated and healed ACL ulcers; only 34% of these patients had elevated antilaminin antibodies. Eighty-four percent of chronic Chagas' disease patients were also found to contain antilaminin antibodies that were limited to the immunoglobulin G class, but these were not detected in patients suffering from any of 11 other infectious diseases.

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Section: Resultssupporting

confidence: 58%

Antibodies to laminin in American cutaneous leishmaniasis

Avila¹,

Rojas²,

Rieber³

1984

Infect Immun

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“…Apparently, the local IL-4 production is insufficient to block induction of the type 1 lymphokines. The elevated Ig levels in MCL patients provide evidence for production ofthe type 2 lymphokines (5,35). Interestingly, parallel studies ofpatients in Venezuela indicate that the highest levels of IL-4 mRNA occur in patients with diffuse cutaneous leishmaniasis (Dittmar et al, manuscript in preparation).…”

Section: Discussionmentioning

confidence: 78%

Cytokine patterns in the pathogenesis of human leishmaniasis.

Pirmez

Yamamura²,

Uyemura³

et al. 1993

J. Clin. Invest.

332

213

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The host response to infection appears to be regulated by specific patterns of local cytokine production. In the mouse, resistance to many pathogens including Leishmania is associated with a THl cytokine profile, IL-2 and IFN-,y; whereas susceptibility to infection is associated with production of TH2 cytokines, IL4, IL-5, and IL-10. To determine the cytokine patterns of the local immune response to Leishmania infection in humans, we used the polymerase chain reaction to compare cytokine mRNAs in biopsy specimens of American cutaneous leishmaniasis. In localized cutaneous leishmaniasis and the Montenegro delayed-type hypersensitivity reaction, type 1 cytokine mRNAs such as IL-2, IFN-y, and lymphotoxin were relatively predominant. In the chronic and destructive mucocutaneous form of leishmaniasis, there was a mixture of type 1 and type 2 cytokines, with a striking abundance of IL4 mRNA in lesions. These results suggest that clinical course of infection with Leishmania braziliensis in man is associated with specific local patterns of cytokine production. (J. Clin. Invest. 1993.

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“…Prior research attempts employing nonrecombinant antigens in the design of serological tests for leishmaniasis were limited by problems with sensitivity, specificity, and test reproducibility (1,11,23). Reasons for these limitations remain elusive but are likeliest attributable to physical and chemical techniques used in antigen preparation.…”

Section: Discussionmentioning

confidence: 99%

Enzyme-Linked Immunosorbent Assay Based on Soluble Promastigote Antigen Detects Immunoglobulin M (IgM) and IgG Antibodies in Sera from Cases of Visceral and Cutaneous Leishmaniasis

et al. 2002

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Leishmaniasis causes significant morbidity and mortality in areas where it is endemic. In areas where it is nonendemic, global travel and increased incidence of the disease in human immunodeficiency virus and intravenous-drug user populations are also causes for concern. The unavailability of rapid and reliable tests for diagnosis of the various leishmaniases makes patient management difficult. We have developed an enzymelinked immunosorbent assay (ELISA) that can detect immunoglobulin M (IgM) and IgG antibodies in patients with visceral and cutaneous leishmaniasis. These practical assays are based on soluble antigens from promastigotes cultivated in a protein-free medium. In preliminary studies, 129 visceral (Brazil, Italy, North Africa, and Nepal) and 143 cutaneous (Brazil) leishmaniasis patients with controls were tested. Overall, the tests showed a sensitivity of 95.1%. In addition, the ELISA correctly identified 42 sera from Brazilian dogs with canine leishmaniasis and 10 healthy controls. Serological tests for the various clinical manifestations of leishmaniasis could be useful epidemiological and patient management tools in populations of areas of endemicity and nonendemicity.

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Circulating Immune Complexes and Anti-IgG Antibodies in Mucocutaneous Leishmaniasis *

Cited by 28 publications

References 0 publications

Antibodies to laminin in American cutaneous leishmaniasis

Antibodies to laminin in American cutaneous leishmaniasis

Cytokine patterns in the pathogenesis of human leishmaniasis.

Enzyme-Linked Immunosorbent Assay Based on Soluble Promastigote Antigen Detects Immunoglobulin M (IgM) and IgG Antibodies in Sera from Cases of Visceral and Cutaneous Leishmaniasis

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