Circulating IgG antibodies against fungal and actinomycete antigens in the sera of farmer's lung patients from different countries

Kurup, Viswanath P.; Mäntyjärvi, Rauno; Terho, E. O.; Ojanen, Tarja; Kalbfleisch, John H.

doi:10.1007/bf00437294

Cited by 31 publications

(12 citation statements)

References 19 publications

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“…The choice of antigenic panel was based on the recognised causes of FL and HP due to moulds at an international [20, 21] and local level [22, 23]. The antigenic panel tested included Lichtheimia corymbifera , Wallemia sebi , Eurotium amstelodami , Fusarium oxysporum , Saccharopolyspora rectivirgula , Thermoactinomyces vulgaris , Streptomyces mesophile and Saccharomonospora viridis .…”

Section: Methodsmentioning

confidence: 99%

Emphysema in active farmer’s lung disease

et al. 2017

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BackgroundFarmer’s lung (FL) is a common type of hypersensitivity pneumonitis. It is often considered that fibrosis is the most frequent finding in chronic FL. Nevertheless, three cohort studies have suggested that some patients with chronic FL may develop emphysema. We aimed to evaluate the current prevalence of emphysema in active FL, to describe the radiological and functional features of emphysema in active FL, and to identify risk factors associated with emphysema in this population.MethodsPatients aged over 18 years with active FL were prospectively recruited through the SOPHIA study (CPP Est; P-2009-521), between 2007 and 2015. Each patient had complete medical history screening, clinical examination, high resolution computed tomodensitometry, bronchoalveolar lavage, pulmonary function tests and serum precipitins.ResultsAmong 33 patients with active FL, the prevalence of emphysema in this series of incident active FL cases was higher (48.5%) than that of fibrosis (12%) and was not dependent on smoking habits. Most patients with emphysema did not have lung hyperinflation. The possible risk factors for emphysema in active FL were a longer duration of exposure to organic dusts, and at a higher level.ConclusionEmphysema is found in half of patients with active FL and may be influenced by exposure patterns.

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Section: Methodsmentioning

confidence: 99%

Emphysema in active farmer’s lung disease

et al. 2017

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“…The choice of antigenic panel was based on the recognised causes of FL and HP due to moulds at an international [15,16] and local level [11]. The antigenic panel tested included Absidia corymbifera, Eurotium amstelodami, Wallemia sebi, Aspergillus fumigatus, Saccharopolyspora rectivirgula, mesophilic Streptomyces sp.…”

Section: Precipitins Testsmentioning

confidence: 99%

Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis

Fenoglio¹,

Reboux²,

Súdre³

et al. 2006

Eur Respir J

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Serum precipitins have a controversial diagnostic value in hypersensitivity pneumonitis (HP). The present authors' objective was to assess their diagnostic value by developing scores from a panel of specific antigens tested by two techniques (electrosyneresis and double diffusion) to discriminate active HP from other interstitial lung diseases.Consecutive patients presenting with a condition for which HP was considered in the differential diagnosis were included in the study. All patients underwent the same standardised diagnostic procedure, including precipitin tests performed in routine conditions. Clinical manifestations, bronchoalveolar lavage and high-resolution computed tomography defined the presence or absence of HP. Receiver-operating characteristic curves and logistic regression were used to develop the serological scores.A total of 122 patients (including 31 cases of HP) were included in the study. Five antigens from the panel were selected for the serological scores (Absidia corymbifera, Eurotium amstelodami, Wallemia sebi, Saccharopolyspora rectivirgula and mesophilic Streptomyces sp.). Electrosyneresis was more discriminative than the double-diffusion technique. Predictive negative values varied 81-88% and predictive positive values varied 71-75% for prevalence of HP 20-35%.In conclusion, serological scores using a panel of relevant antigens may guide both biological and clinical practice in areas of high prevalence of hypersensitivity pneumonitis.

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“…In the chronic disease, diffuse interstitial fibrosis is common, and cystic changes may be evident. In addition, experimental animal models have been developed to elucidate potential pathogenic mechanisms involved in the disease (428,633 (285,315,375,480,632). Following a single attack, these antibodies may persist for variable periods; however, in most patients, these antibodies are lost after approximately 3 years.…”

Section: Opportunistic Pathogenic Actinomycetesmentioning

confidence: 99%

The medically important aerobic actinomycetes: epidemiology and microbiology

1994

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The aerobic actinomycetes are soil-inhabiting microorganisms that occur worldwide. In 1888, Nocard first recognized the pathogenic potential of this group of microorganisms. Since then, several aerobic actinomycetes have been a major source of interest for the commercial drug industry and have proved to be extremely useful microorganisms for producing novel antimicrobial agents. They have also been well known as potential veterinary pathogens affecting many different animal species. The medically important aerobic actinomycetes may cause significant morbidity and mortality, in particular in highly susceptible severely immunocompromised patients, including transplant recipients and patients infected with human immunodeficiency virus. However, the diagnosis of these infections may be difficult, and effective antimicrobial therapy may be complicated by antimicrobial resistance. The taxonomy of these microorganisms has been problematic. In recent revisions of their classification, new pathogenic species have been recognized. The development of additional and more reliable diagnostic tests and of a standardized method for antimicrobial susceptibility testing and the application of molecular techniques for the diagnosis and subtyping of these microorganisms are needed to better diagnose and treat infected patients and to identify effective control measures for these unusual pathogens. We review the epidemiology and microbiology of the major medically important aerobic actinomycetes.

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Circulating IgG antibodies against fungal and actinomycete antigens in the sera of farmer's lung patients from different countries

Cited by 31 publications

References 19 publications

Emphysema in active farmer’s lung disease

Emphysema in active farmer’s lung disease

Diagnostic value of serum precipitins to mould antigens in active hypersensitivity pneumonitis

The medically important aerobic actinomycetes: epidemiology and microbiology

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