Circulating IGFBP-2 levels are incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides

Abstract

In our cohort, IGFBP-2 levels <221.5 ng/mL are incrementally associated with a detrimental plasma lipoprotein-lipid profile. After adjustment for covariates, IGFBP-2 remained independently associated with VLDL-TG but not HDL-C levels. This study supports further investigations in other populations and validation of IGFBP-2 as a biomarker of early dyslipidemia.

Relationship Between Insulin-Like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients With Aortic Stenosis

“…They also exhibited decreased insulin sensitivity assessed according to higher fasting insulin levels and HOMA index. These findings are consistent with previous reports [11][12][13][14] and might suggest that IGFBP-2 could be used as a biomarker of metabolic alterations linked to visceral obesity. Interestingly, SV indexed to the 2.04 power of height or "ideal BSA" remained associated with IGFBP-2 levels.…”

“…8,9 Recent experimental studies showed that overexpression of human IGFBP-2 in rodents protects against age and diet-induced insulin resistance. 10 Consistently, lower circulating levels of IGFBP-2 have been associated with obesity, insulin resistance, and dyslipidemia in humans, [11][12][13] leading to the postulate that plasma IGFBP-2 could be a biomarker for the MetS. 14 We therefore hypothesized that circulating levels of IGFBP-2 could be associated with the worsening of myocardial structure and function in AS.…”

Changes in IGFBP-2 levels following a one-year lifestyle modification program are independently related to improvements in plasma apo B and LDL apo B levels

“…In the present study, total circulating IGFBP-2 levels were within the range reported in men with mild dyslipidemia and increased adiposity Log-transformed variables. [8,12,33,34]. Following the 1-year intervention, average IGFBP-2 levels were increased by 43%, which is consistent with the upregulation observed after weight loss achieved by dieting alone [19].…”

“…Additional transversal associations between IGFBP-2 levels and components of the lipoprotein-lipid profile, mostly TG and HDL cholesterol, were also described by others [11,13]. Further analyses suggested that subjects with low IGFBP-2 levels display an increased number of TG-rich particles as assessed by elevated apo B concentrations [12]. In turn, both overexpression of IGFBP-2 in mice and IGFBP-2 treatment to 3T3-L1 adipocyte cultures enhance uptake and metabolism of energy substrates, through yet unclear, partially IGF-1-independent mechanisms, including a possible attenuation of α5β1 integrins and intracellular PTEN signaling [14,15].…”

“…Lower circulating levels of insulin-like growth factor (IGF) binding protein-2 (IGFBP-2) have been associated with increased fat mass, insulin resistance and abnormalities in the lipoprotein-lipid profile in children [7] and adults [8][9][10][11]. We recently showed that human subjects with low IGFBP-2 levels have an increased risk of showing metabolic alterations linked to the metabolic syndrome [12]. Additional transversal associations between IGFBP-2 levels and components of the lipoprotein-lipid profile, mostly TG and HDL cholesterol, were also described by others [11,13].…”