Circulating Histones and Severity of Illness in Children with Sepsis: A Prospective Observational Study

Extracellular Histones—Friend or Foe?

“…There is a paucity of studies on the role of histones in critically ill children with sepsis. One of the first studies in this area conducted at a tertiary care hospital in India by Sidana et al warrants attention [4]. This prospective observational study aimed to measure circulating histone H3 levels in children with severe sepsis, and evaluate its role in the severity of illness and organ dysfunction.…”

“…Association between high histone levels and thrombocytopenia has been shown in critically ill adult patients [6]. The study by Sidana et al also demonstrated higher H3 levels in patients with thrombocytopenia, though the difference was not statistically significant [4].…”