Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder.

Khoory, M S; Nesheim, ME; Bowie, E. J. W.; Mann, KG

doi:10.1172/jci109712

Cited by 74 publications

(43 citation statements)

References 35 publications

(22 reference statements)

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“…On the one hand, endothelial cells could liberate aHSPGs into interstitial fluid and then into the blood stream, which would allow these components to regulate plasma AT and hence control the action of the coagulation mechanism. It is of interest to note that rare instances have been described of circulating heparin-like anticoagulants associated with various pathologic situations such as multiple myeloma and bladder carcinoma [Khoory et al, 1980;Palmer et al, 1984;Tefferi et al, 19891. Horne and colleagues have also reported the presence of circulating anticoagulant glycosaminoglycans in patients with liver damage subsequent to suramin treatment of tumors [Horne et al, 19881.…”

Section: Discussionmentioning

confidence: 99%

Differential partition of anticoagulant heparan sulfate proteoglycans synthesized by endothelial and fibroblastic cell lines

Agostini

Ramus

Rosenberg

1994

J of Cellular Biochemistry

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The heparan sulfate proteoglycans that bind and activate antithrombin III (aHSPGs) are synthesized by endothelial cells as well as other nonvascular cells. We determined the amounts of cell surface-associated and soluble aHSPGs generated by the rat fat pad endothelial (RFP) cell line and the fibroblast (LTA) cell line. The RFP cells exhibit higher levels of cell surface-associated aHSPGs as compared to LTA cells, whereas LTA cells release larger amounts of soluble aHSPGs as compared to RFP cells. After confluence RFP cells show an increase in both cell surface-associated and soluble aHSPGs. In contrast, postconfluent LTA cells maintain a constant level of cell surface-associated and soluble aHSPGs. These observations indicate that different cell types can preferentially accumulate aHSPGs as cell surface-associated or soluble forms which could reflect alternate biological functions.

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Section: Discussionmentioning

confidence: 99%

Differential partition of anticoagulant heparan sulfate proteoglycans synthesized by endothelial and fibroblastic cell lines

Agostini

Ramus

Rosenberg

1994

J of Cellular Biochemistry

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“…An example of a quantitative alteration of heparan sulfate, i.e., overproduction of this glycosaminoglycan, linked to neoplasia is offered by patients with multiple myeloma in whom high levels of circulating heparan sulfate with anticoagulant activity have been detected [66,67]. Coagulation studies have shown that the circulating heparan sulfate had anti-thrombin III cofactor activity that could be neutralized by platelet factor 4 or protamine [67].…”

Section: Heparan Sulfate and Transformationmentioning

confidence: 99%

Proteoglycans and neoplasia

Iozzo

1988

Cancer Metast Rev

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There is a growing realization that the whole tumor cell-matrix complex must be investigated in order to fully understand the process of cancer growth and metastasis. Proteoglycans are intrinsic constituents of the cell surface, extracellular matrix, and basement membrane, three logistically and functionally important structures involved in most cellular interactions. Proteoglycans influence the behavior of normal and malignant cells by virtue of their expanded configuration, polyanionic nature and, most of all, by their ability to interact with a variety of cellular products. Consequently, they have been implicated in a number of biological processes including proliferation, recognition, adhesion, and migration. They can serve as links between the extracellular and intracellular environment and thus transduce key biological signals. They can act as receptors for interstitial collagens and other matrix proteins and thus contribute to the organization of pericellular matrix. During neoplastic development there is a profound structural rearrangement of these macromolecules at both the plasma membrane and the pericellular level. Qualitative and quantitative abnormalities in proteoglycan metabolism may contribute to the establishment of some well-known neoplastic properties, including lack of cohesiveness, abnormal assembly of extracellular matrix, abnormal growth, and invasion. The present work will focus on recent advances in our understanding of these complex macromolecules and on some of the alterations associated with the neoplastic phenotype, and will then attempt to elucidate some of the mechanisms regulating these changes.

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“…This may have also represented DS activity which would not have been appreciated since the presence of HC II was not known at that time. Circulating anticoagulant GAG molecules have been noted in some pathologic conditions (42)(43)(44)(45). To our knowledge, this is the first demonstration of this phenomenon in physiologic states.…”

Section: Discussionmentioning

confidence: 99%

An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus.

Andrew

Mitchell²,

Berry³

et al. 1992

J. Clin. Invest.

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Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder.

Cited by 74 publications

References 35 publications

Differential partition of anticoagulant heparan sulfate proteoglycans synthesized by endothelial and fibroblastic cell lines

Differential partition of anticoagulant heparan sulfate proteoglycans synthesized by endothelial and fibroblastic cell lines

Proteoglycans and neoplasia

An anticoagulant dermatan sulfate proteoglycan circulates in the pregnant woman and her fetus.

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