Circulating ghrelin/obestatin ratio in subjects with Helicobacter pylori infection

Gao, Xinyuan; Kuang, Hongyu; Liu, Xiaomin; Duan, Peng; Yang, Yi; Ma, Zongwen

doi:10.1016/j.nut.2008.11.002

Cited by 36 publications

(24 citation statements)

References 42 publications

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“…In patients with Helicobacter pylori -evoked antral gastritis, plasma concentration of ghrelin and gastric expression of mRNA for ghrelin are increased; whereas in the next stage of Helicobacter pylori infection, in chronic atrophic gastritis, level of ghrelin is reduced [4]. Influence of Helicobacter pylori infection on the level of obestatin is unclear [5]. …”

Section: Introductionmentioning

confidence: 99%

Administration of obestatin accelerates the healing of chronic gastric ulcers in rats

et al. 2011

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SummaryBackgroundPrevious studies have shown that administration of obestatin exhibits a protective effect in the pancreas, attenuating the development of acute pancreatitis. The aim of the present study was to investigate the influence of obestatin administration on the healing of chronic gastric ulcers.Material/MethodsChronic gastric ulcers were induced in rats by 100% acetic acid applied to the serosal surface of the gastric wall. Obestatin was given twice a day intraperitoneally at the dose of 4, 8 or 16 nmol/kg/dose for 6 days. Six days after induction of ulcers, rats were anesthetized and the stomach was exposed for measurement of gastric blood flow and ulcer area. Biopsy samples from the gastric mucosa were taken for determination of mucosal DNA synthesis and for measurement of gastric expression of mRNA for interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α).ResultsInduction of gastric ulcers alone increased mucosal blood flow and tissue expression of mRNA for TNF-α and IL-1β, whereas gastric mucosal DNA synthesis was reduced. In rats with gastric ulcers, administration of obestatin increased gastric mucosal blood flow, accelerated the healing rate of these ulcers and partly reversed the gastric ulcer-induced reduction in gastric mucosal DNA synthesis. These results were associated with a reduction in gastric mucosal expression of pro-inflammatory IL-1β and TNF-α.ConclusionsTreatment with obestatin increases gastric mucosal blood flow and cell proliferation, leading to acceleration of healing of gastric ulcers. These effects are associated with a reduction in mucosal expression of pro-inflammatory IL-1β and TNF-α.

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Section: Introductionmentioning

confidence: 99%

Administration of obestatin accelerates the healing of chronic gastric ulcers in rats

et al. 2011

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“…Gao et al’s study showed that ghrelin levels and G/O ratio were lower in the group with H . pylori infection [10]. However, while these two studies addressed obestatin levels, they did not include histological findings, and their study population was not restricted to those with advanced age.…”

Section: Discussionmentioning

confidence: 99%

“…The association between plasma ghrelin levels and H . pylori infection is still controversial [10, 12, 15]. Although Ulasoglu et al reported circulating ghrelin levels decreased in H .…”

Section: Introductionmentioning

confidence: 99%

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Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia

Kim

Byun

et al. 2017

PLoS ONE

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BackgroundWhether plasma ghrelin/obestatin levels are associated with Helicobacter pylori (H. pylori) infection, subtypes of functional dyspepsia (FD), and gastric mucosal histology has not yet been established in elderly patients.ObjectiveThe aim of this study was to determine whether plasma ghrelin and obestatin levels are related to gastric mucosal histology, H. pylori infection, and FD subtypes in elderly patients with FD.MethodsNinety-two patients diagnosed with FD and older than 60 years (median age 69.4; range 60–88) were included. Clinical symptoms investigated included postprandial fullness, epigastric pain, epigastric soreness, nausea, and vomiting. According to the Rome III criteria, patients diagnosed with FD were divided into two subtypes: epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS). Plasma ghrelin and obestatin levels were measured using enzyme immunoassay, and histological examination of gastric mucosa was performed. H. pylori infection was determined by histopathological examination of gastric mucosal biopsy and/or Campylobacter-like organism test.ResultsIn our study, plasma ghrelin levels and plasma ghrelin/obestatin (G/O) ratio were significantly lower in subjects with intestinal metaplasia compared with those without intestinal metaplasia (ghrelin, p = 0.010; G/O ratio, p = 0.012). On the other hand, there were no significant differences in plasma ghrelin and obestatin levels between H. pylori–positive and H. pylori–negative groups. (ghrelin, p = 0.130; obestatin, p = 0.888). Similarly, no significant differences were detected between the EPS and PDS groups (ghrelin, p = 0.238; obestatin, p = 0.710).ConclusionsPatients with intestinal metaplasia, a known precursor of gastric cancer, had significantly less plasma ghrelin levels and G/O ratio than those without intestinal metaplasia.

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“…Leptin concentrations were higher, ghrelin concentrations and ghrelin/ obestatin ratios were lower in the H.pylori-positive group than in the H.pylori-negative group. Additionally, appetite was decreased in H.pylori positive group 12,20 . After the eradication of H.pylori, ghrelin levels and appetite was increased that results in body weight gain 21,22 .…”

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confidence: 93%

The effects of helicobacter pylori infection on nutrition status and metabolism

Özturan¹,

Bilici²

2017

Kafkas J Med Sci

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Circulating ghrelin/obestatin ratio in subjects with Helicobacter pylori infection

Cited by 36 publications

References 42 publications

Administration of obestatin accelerates the healing of chronic gastric ulcers in rats

Administration of obestatin accelerates the healing of chronic gastric ulcers in rats

Plasma ghrelin level and plasma ghrelin/obestatin ratio are related to intestinal metaplasia in elderly patients with functional dyspepsia

The effects of helicobacter pylori infection on nutrition status and metabolism

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